A Clinically Applicable and Scalable Method To Regenerate T-Cells from iPSCs for Off-the-Shelf T-Cell Immunotherapy

Scientists showed improved differentiation efficiency of T-cells from induced PSCs (iPSCs) derived from an antigen-specific cytotoxic T-cell clone, or from T-cell receptor-transduced iPSCs, as starting materials.
[Nature Communications]
Iriguchi, S., Yasui, Y., Kawai, Y., Arima, S., Kunitomo, M., Sato, T., Ueda, T., Minagawa, A., Mishima, Y., Yanagawa, N., Baba, Y., Miyake, Y., Nakayama, K., Takiguchi, M., Shinohara, T., Nakatsura, T., Yasukawa, M., Kassai, Y., Hayashi, A., & Kaneko, S. (2021). A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy. Nature Communications, 12(1), 430. https://doi.org/10.1038/s41467-020-20658-3 Cite
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Human Intestinal Tissue-Resident Memory T Cells Comprise Transcriptionally and Functionally Distinct Subsets

Researchers investigated transcriptional and functional heterogeneity of human tissue-resident memory T (TRM) cells through study of donor-derived TRM cells from intestinal transplant recipients.
[Cell Reports]
FitzPatrick, M. E. B., Provine, N. M., Garner, L. C., Powell, K., Amini, A., Irwin, S. L., Ferry, H., Ambrose, T., Friend, P., Vrakas, G., Reddy, S., Soilleux, E., Klenerman, P., & Allan, P. J. (2021). Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets. Cell Reports, 34(3). https://doi.org/10.1016/j.celrep.2020.108661 Cite
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EGR1 Is a Gatekeeper of Inflammatory Enhancers in Human Macrophages

Researchers analyzed the molecular determinants of monocytic and macrophagic commitment by profiling the EGR1 transcription factor. EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R.
[Science Advances]
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages | Science Advances. (n.d.). Retrieved January 18, 2021, from https://advances.sciencemag.org/content/7/3/eaaz8836 Cite
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Induction of IL-10-Producing Type 2 Innate Lymphoid Cells by Allergen Immunotherapy Is Associated with Clinical Response

Scientists report a role of interleukin-10-producing type 2 innate lymphoid cells in modulating grass-pollen allergy.
[Immunity]
Golebski, K., Layhadi, J. A., Sahiner, U., Steveling-Klein, E. H., Lenormand, M. M., Li, R. C. Y., Bal, S. M., Heesters, B. A., Vilà-Nadal, G., Hunewald, O., Montamat, G., He, F. Q., Ollert, M., Fedina, O., Lao-Araya, M., Vijverberg, S. J. H., Zee, A.-H. M. der, Drunen, C. M. van, Fokkens, W. J., … Shamji, M. H. (2021). Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.12.013 Cite
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Targeting Ubiquitin Signaling for Cancer Immunotherapy

[Signal Transduction and Targeted Therapy]
Zhou, X., & Sun, S.-C. (2021). Targeting ubiquitin signaling for cancer immunotherapy. Signal Transduction and Targeted Therapy, 6(1), 1–15. https://doi.org/10.1038/s41392-020-00421-2 Cite
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Antitumor Immunity Regulated by Aberrant ERBB Family Signaling

The authors discuss the mechanisms by which the signaling of ERBB family members affects not only autonomous cancer hallmarks, such as uncontrolled cell proliferation, but also antitumor immune responses in the tumor microenvironment and the potential application of immune-genome precision medicine into immunotherapy.
[Nature Reviews Cancer]
Kumagai, S., Koyama, S., & Nishikawa, H. (2021). Antitumour immunity regulated by aberrant ERBB family signalling. Nature Reviews Cancer, 1–17. https://doi.org/10.1038/s41568-020-00322-0 Cite
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A Subset of Liver Resident Natural Killer Cells Is Expanded in Hepatitis C-Infected Patients with Better Liver Function

LMCs were less responsive to toll-like receptor stimulation than blood mononuclear cells, with fewer pro-inflammatory gene-expression pathways up-regulated after in vitro exposure to lipopolysaccharide and a TLR-7/8 agonist.
[Scientific Reports]
Doyle, E. H., Aloman, C., El-Shamy, A., Eng, F., Rahman, A., Klepper, A. L., Haydel, B., Florman, S. S., Fiel, M. I., Schiano, T., & Branch, A. D. (2021). A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function. Scientific Reports, 11(1), 1551. https://doi.org/10.1038/s41598-020-80819-8 Cite
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The HIV Protease Inhibitor Saquinavir Attenuates Sepsis-Induced Acute Lung Injury and Promotes M2 Macrophage Polarization via Targeting Matrix Metalloproteinase-9

Scientists focused on the important role of macrophage polarization in cecal ligation puncture-mediated acute lung injury and determined the ability of saquinavir to maintain M2 over M1 phenotype partially through the inhibition of matrix metalloproteinase-9.
[Cell Death & Disease]
Tong, Y., Yu, Z., Chen, Z., Zhang, R., Ding, X., Yang, X., Niu, X., Li, M., Zhang, L., Billiar, T. R., Pitt, B. R., & Li, Q. (2021). The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03320-0 Cite
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Granzyme B Inhibition Reduces Disease Severity in Autoimmune Blistering Diseases

Scientists explored the role of the immune cell-secreted serine protease, granzyme B, in pemphigoid disease pathogenesis using three independent murine models. In all models, granzyme B knockout or topical pharmacological inhibition significantly reduces total blistering area compared to controls.
[Nature Communications]
Hiroyasu, S., Zeglinski, M. R., Zhao, H., Pawluk, M. A., Turner, C. T., Kasprick, A., Tateishi, C., Nishie, W., Burleigh, A., Lennox, P. A., Van Laeken, N., Carr, N. J., Petersen, F., Crawford, R. I., Shimizu, H., Tsuruta, D., Ludwig, R. J., & Granville, D. J. (2021). Granzyme B inhibition reduces disease severity in autoimmune blistering diseases. Nature Communications, 12(1), 302. https://doi.org/10.1038/s41467-020-20604-3 Cite
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Multi-Level Remodeling of Chromatin Underlying Activation of Human T Cells

To characterize coordinate changes at different levels of chromatin architecture, researchers analyzed chromatin accessibility, chromosome conformation and gene expression in activated human T cells.
[Scientific Reports]
Bediaga, N. G., Coughlan, H. D., Johanson, T. M., Garnham, A. L., Naselli, G., Schröder, J., Fearnley, L. G., Bandala-Sanchez, E., Allan, R. S., Smyth, G. K., & Harrison, L. C. (2021). Multi-level remodelling of chromatin underlying activation of human T cells. Scientific Reports, 11(1), 528. https://doi.org/10.1038/s41598-020-80165-9 Cite
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Tissue-Specific Transcriptional Imprinting and Heterogeneity in Human Innate Lymphoid Cells Revealed by Full-Length Single-Cell RNA-Sequencing

Scientists used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ ILCs across four human tissues.
[Cell Research]
Mazzurana, L., Czarnewski, P., Jonsson, V., Wigge, L., Ringnér, M., Williams, T. C., Ravindran, A., Björklund, Å. K., Säfholm, J., Nilsson, G., Dahlén, S.-E., Orre, A.-C., Al-Ameri, M., Höög, C., Hedin, C., Szczegielniak, S., Almer, S., & Mjösberg, J. (2021). Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing. Cell Research, 1–15. https://doi.org/10.1038/s41422-020-00445-x Cite
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