Highly Efficient PD-1-Targeted CRISPR-Cas9 for Tumor-Infiltrating Lymphocyte-Based Adoptive T Cell Therapy

Non-viral/plasmid-based programmed cell death protein 1 (PD-1) knockout was carried out immediately prior to the traditional 14-day tumor-infiltrating lymphocytes-based ACT rapid expansion protocol.
[Molecular Therapy Oncolytics]
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A Subset of Follicular Helper-Like MAIT Cells Can Provide B Cell Help and Support Antibody Production in the Mucosa

Scientists described a population of CXCR5+ T follicular helper–like mucosal-associated invariant T (MAIT) cells that have the capacity to provide B cell help within mucosal lymphoid organs.
[Science Immunology]
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Neutrophils in Chronic Inflammatory Diseases

The authors highlight the interaction of neutrophils with other cells in the context of chronic inflammation, the contribution of neutrophils to selected chronic inflammatory diseases, and possible future therapeutic strategies.
[Cellular & Molecular Immunology]
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PDGF-D−PDGFRβ Signaling Enhances IL-15–Mediated Human Natural Killer Cell Survival

Scientists reported an additional but previously unknown role of PDGF-D, whereby it mediated interleukin-15–induced human NK cell survival but not effector functions via its binding to PDGFRβ but independent of its binding to NKp44.
[Proceedings of the National Academy of Sciences of the United States of America]
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Programmed Cell Death 1 Ligand 1 Signals in Cancer Cells

The authors discuss historical and recent advances in understanding cancer cell-intrinsic PDL1 signals, mechanisms for signal controls and important immunopathologic consequences including resistance to cytotoxic agents, targeted small molecules and immunotherapies.
[Nature Reviews Cancer]
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Boosting NAD+ Blunts Toll-Like Receptor-4 Induced Type-I Interferon in Control and Systemic Lupus Erythematosus Monocytes

Scientists explored the underlying biology in myeloid cells from healthy volunteers following in vivo placebo or nicotinamide riboside administration and subsequently tested the findings in vitro in monocytes extracted from subjects with systemic lupus erythematosus.
[Journal of Clinical Investigation]
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Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing

The authors integrated six bead-enriched T cell subsets with 62,235 single-cell transcriptomes from human PBMCs and clustered them into nine scRNA-seq clustered populations.
[Journal of Immunology]
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Circulating CD8+ Mucosal-Associated Invariant T Cells Correlate with Improved Treatment Responses and Overall Survival in Anti-PD-1-Treated Melanoma Patients

Investigators analyzed the frequency and functional profile of circulating and tumor-infiltrating mucosal-associated invariant T cells in human melanoma patients. Using flow cytometry, they compared these across metastatic sites and between ICI responders vs. non-responders as well as healthy donors.
[Clinical & Translational Immunology]
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Demethylase JMJD2D Induces PD-L1 Expression to Promote Colorectal Cancer Immune Escape by Enhancing IFNGR1-STAT3-IRF1 Signaling

Scientists reported that both PD-L1 and JMJD2D were frequently overexpressed in human colorectal cancer specimens with a significant positive correlation.
[Oncogene]
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Key Interactions in the Trimolecular Complex Consisting of the Rheumatoid Arthritis-Associated DRB1*04:01 Molecule, the Major Glycosylated Collagen II Peptide and the T Cell Receptor

The crystal structures identified peptide binding to DRB1*04:01 and potential side chain exposure to T cells.
[Annals of the Rheumatic Diseases]
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Adenosine Receptor A2a Blockade by Caffeine Increases IFN–Gamma Production in Th1 Cells from Patients with Rheumatoid Arthritis

Peripheral blood mononuclear cells were obtained from the peripheral blood of healthy individuals and patients with rheumatoid arthritis.
[Scandinavian Journal of Rheumatology]
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