MoonLake Immunotherapeutics AG and Helix Acquisition Corp. Announce Business Combination Agreement to Create Publicly Listed Biotechnology Company Advancing Tri-specific Nanobody® Sonelokimab

MoonLake Immunotherapeutics AG, a clinical-stage biotechnology company focused on creating next-level therapies for inflammatory skin and joint diseases and Helix Acquisition Corp. (Nasdaq: HLXA), a special purpose acquisition company (SPAC) sponsored by Cormorant Asset Management, today announced they have entered into a definitive business combination agreement.
[MoonLake Immunotherapeutics AG]
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γδ T Cells Support Antigen-Specific αβ T Cell-Mediated Antitumor Responses during BCG Treatment for Bladder Cancer

Scientists showed that Bacillus Calmette-Guérin (BCG) increased the number of tumor antigen-specific αβ T cells in patients with bladder cancer.
[Cancer Immunology Research]
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Soluble PD-L1 Is a Predictive and Prognostic Biomarker in Advanced Cancer Patients Who Receive Immune Checkpoint Blockade Treatment

Researchers investigated the significance of sPD-L1 in cancer patients receiving immune checkpoint inhibitor therapy.
[Scientific Reports]
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Inhibition of the BTK-IDO-mTOR Axis Promotes Differentiation of Monocyte-Lineage Dendritic Cells and Enhances Anti-Tumor T Cell Immunity

Researchers examined how targeting pathways that inhibit the differentiation of inflammatory myeloid cells affect antitumor immunity.
[Immunity]
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CD177 Modulates the Function and Homeostasis of Tumor-Infiltrating Regulatory T Cells

Using single-cell RNA sequencing of immune cells from renal clear cell carcinoma patients, investigators identified two distinct transcriptional fates for tumor-infiltrating Treg cells, Fate-1 and Fate-2.
[Nature Communications]
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Anti-CD40 Antibodies Fused to CD40 Ligand Have Superagonist Properties

The authors showed that direct fusion of CD40L to certain agonistic anti-CD40 Abs conferred superagonist properties, reducing the dose required for efficacy, notably greatly increasing total cytokine secretion by human dendritic cells.
[Journal of Immunology]
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The Fellowship of Regulatory and Tissue-Resident Memory Cells

T cells located in non-lymphoid tissues have come to prominence in recent years. CD8+ tissue-resident memory cells are important for tissue immune surveillance, provide an important line of defence against invading pathogens and show promise in cancer therapies.
[Mucosal Immunology]
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CD47-Targeted Cancer Immunogene Therapy: Secreted SIRPα-FC Fusion Protein Eradicates Tumors by Macrophage and NK Cell Activation

Researchers developed a plasmid-vector encoding for the secreted fusion protein sCV1-hIgG1, comprising of highly efficient CD47-blocking moiety CV1 and Fc domain of human IgG1 with maximized immune activation.
[Molecular Therapy-Oncolytics]
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Identification of Immune-Related Subtypes of Colorectal Cancer to Improve Antitumor Immunotherapy

42.8% of patients who exhibited significantly higher immunocyte infiltration and enrichment of immune response-associated signatures were subdivided into immune classes.
[Scientific Reports]
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TIGIT Induces (CD3+) T Cell Dysfunction in Colorectal Cancer by Inhibiting Glucose Metabolism

Scientists found that the proportion of CD3+TIGIT+ T cells was increased in peripheral blood and cancer tissue in colorectal cancer patients when compared with the healthy donors.
[Frontiers in Immunology]
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Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies

The authors recruited 114 patients with B cell malignancies, comprising 77 acute lymphoblastic leukemia and 37 non-Hodgkin lymphoma patients, who were treated with CART19 cells.
[Journal of the National Cancer Institute]
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