Tumor-Associated Macrophages in Classical Hodgkin Lymphoma: Hormetic Relationship to Outcome

MYC+ cells accounted for 21% and 18% of CD68+ and CD163+ cells, respectively. Numbers of MYC macrophages were significantly higher in EBV+ cases while no differences were observed for MYC+ macrophages between EBV+ and EBV cases.
[Scientific Reports]
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Reference Genes for Expression Studies in Human CD8+ Naïve and Effector Memory T Cells under Resting and Activating Conditions

Researchers evaluated twelve commonly used reference gene products in human naïve and effector memory CD8+ T cells under non-activated and activated conditions. They used five different statistical approaches for data analysis.
[Scientific Reports]
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convertibleCARs: A Chimeric Antigen Receptor System for Flexible Control of Activity and Antigen Targeting

An inert form of the human NKG2D extracellular domain (iNKG2D) was engineered as the ectodomain of the chimeric antigen receptor (CAR) to generate convertibleCARTM-T cells. These cells were specifically directed to kill antigen-expressing target cells only in the presence of an activating bispecific adapter comprised of an iNKG2D-exclusive ULBP2-based ligand fused to an antigen-targeting antibody
[Communications Biology]
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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Investigators summarize and question what is known and remains to be discovered about the TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.
[Cell]
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DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25

Investigators showed that neutrophil extracellular traps (NETs) were abundant in the liver metastases of patients with breast and colon cancers, and that serum NETs could predict the occurrence of liver metastases in patients with early-stage breast cancer.
[Nature]
Yang, L., Liu, Q., Zhang, X., Liu, X., Zhou, B., Chen, J., … Song, E. (2020). DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature, 1–6. https://doi.org/10.1038/s41586-020-2394-6 Cite
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Old Dogs, New Trick: Classic Cancer Therapies Activate cGAS

The authors review the antitumor roles of the GMP-AMP synthase (cGAS-STING) pathway during tumorigenesis, cancer immune surveillance, and cancer therapies. They also highlight classic cancer therapies that elicit antitumor immune responses through cGAS activation.
[Cell Research]
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Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-Tumor Activity

The authors developed human cytokine-inducible SH2-containing protein-knockout (CISH−/−) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform. CISH−/− iPSC-NK cells demonstrated increased IL-15-mediated JAK-STAT signaling activity.
[Cell Stem Cell]
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Dissecting Intratumour Heterogeneity of Nodal B-Cell Lymphomas at the Transcriptional, Genetic and Drug-Response Levels

Researchers identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment.
[Nature Cell Biology]
Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels | Nature Cell Biology. (n.d.). Retrieved June 16, 2020, from https://www.nature.com/articles/s41556-020-0532-x Cite
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Inosine Is an Alternative Carbon Source for CD8+-T-Cell Function under Glucose Restriction

Scientists showed that effector T cells could utilize inosine, as an alternative substrate, to support cell growth and function in the absence of glucose in vitro. T cells metabolized inosine into hypoxanthine and phosphorylated ribose by purine nucleoside phosphorylase.
[Nature Metabolism]
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A Variant in IL6ST with a Selective IL-11 Signaling Defect in Human and Mouse

Researchers characterized the impact of a variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and supported these findings using a mouse model with the corresponding genome-edited variant Il6st p.R279Q.
[Bone Research]
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Intragenic Recruitment of NF-κB Drives Splicing Modifications upon Activation by the Oncogene Tax of HTLV-1

Investigators demonstrated that recruitment of the NF-κB factor RELA to intragenic regions regulated alternative splicing upon NF-κB activation by the viral oncogene tax of HTLV-1.
[Nature Communications]
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