Scientists used machine learning approaches to predict serum levels of some adipokines/related inflammatory factors and their ratios on knee infrapatellar fat pad volume of osteoarthritis patients.
[Scientific Reports]
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Category Archives: Human Immunology
Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
Serum Adipokines/Related Inflammatory Factors and Ratios as Predictors of Infrapatellar Fat Pad Volume in Osteoarthritis: Applying Comprehensive Machine Learning Approaches
Difference in Presence and Number of CD83+ Dendritic Cells in Patients with Ulcerative Colitis and Crohn’s Disease
There were 154 subjects included in this study: 60 with ulcerative colitis, 19 with Crohn’s disease and 75 in the control group. Colonic biopsy was performed in all subjects. Specimens were incubated with a primary anti-CD83 antibody.
[Scientific Reports]
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Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis
Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America]
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Determinants of Resident Tissue Macrophage Identity and Function
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy
The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]
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Tumor-Induced Neurogenesis and Immune Evasion as Targets of Innovative Anti-Cancer Therapies
The authors discuss the potential of anti-neurogenesis and, considering the interplay between nervous and immune systems, they also focus on anti-immunosuppression-based therapies.
[Signal Transduction and Targeted Therapy]
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Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19
Several of the cytokines involved in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs). JAK inhibition, therefore, presents an attractive therapeutic strategy for cytokine release syndrome, which is a common cause of adverse clinical outcomes in COVID-19.
[Trends in Pharmacological Sciences]
Luo, W., Li, Y.-X., Jiang, L.-J., Chen, Q., Wang, T., & Ye, D.-W. (2020). Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19. Trends in Pharmacological Sciences, 0(0). https://doi.org/10.1016/j.tips.2020.06.007 Cite
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UCLA Receives Nearly $14 Million from NIH to Investigate Gene Therapy to Combat HIV
University of California, Lost Angeles (UCLA) researchers and colleagues have received a $13.65 million grant from the National Institutes of Health to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
[Univesity of California, Los Angeles]
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Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages
Scientists summarize the roles and mechanisms of exosomes in the interaction between tumor cells and macrophages and the potential methods by which exosomes are used to target the communication between tumor cells and macrophages to treat cancer.
[Molecular Therapy]
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Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo
The authors created a chimeric antigen-receptor (CAR) that was capable of on-demand downregulation by fusing the CAR to a previously developed ligand-induced degradation domain. Addition of a small molecule ligand triggered exposure of a cryptic degron within the ligand-induced degradation domain (LID), resulting in proteasomal degradation of the CAR-LID fusion protein and loss of CAR on the surface of T cells.
[Molecular Therapy]
Ligand-induced degradation of a CAR permits reversible remote control of CAR T cell activity in vitro and in vivo: Molecular Therapy. (n.d.). Retrieved June 16, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30294-X Cite
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CRISPR-Cas9 Mediated Glucocorticoid Resistance in Virus-Specific T Cells for Adoptive T-Cell Therapy Post Transplantation
In order to deliver protection against viral pathogens and allow at the same time necessary steroid therapy, scientists generated glucocorticoid-resistant T cells by CRISPR/Cas9-mediated knockout of the glucocorticoid receptor in primary human virus-specific T-cell products.
[Molecular Therapy]
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