Radiogenomics for Predicting p53 Status, PD-L1 Expression, and Prognosis with Machine Learning in Pancreatic Cancer

107 patients diagnosed with pancreatic ductal adenocarcinoma were retrospectively examined. The relationship between p53 mutations as well as PD-L1 abnormal expression and clinicopathological factors was investigated using immunohistochemistry.
[British Journal of Cancer]
Iwatate, Y., Hoshino, I., Yokota, H., Ishige, F., Itami, M., Mori, Y., Chiba, S., Arimitsu, H., Yanagibashi, H., Nagase, H., & Takayama, W. (2020). Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-0997-1 Cite
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GlyTherix Awarded $3 Million Co-Operative Research Center Project Grant

GlyTherix Ltd has announced that a consortium led by the company are the successful recipients of a competitive grant in Round 9 of the Federal Government’s Cooperative Research Centers Projects program.
[GlyTherix Ltd.]
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Neutrophil Diversity and Plasticity in Tumor Progression and Therapy

The authors surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches.
[Nature Reviews Cancer]
Jaillon, S., Ponzetta, A., Di Mitri, D., Santoni, A., Bonecchi, R., & Mantovani, A. (2020). Neutrophil diversity and plasticity in tumour progression and therapy. Nature Reviews Cancer, 1–19. https://doi.org/10.1038/s41568-020-0281-y Cite
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The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News]
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EU Leaders Slash Science Spending in €1.8 Trillion Deal

Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[Science Insider]
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‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider]
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Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints

Amid concerns that the torrent of research papers on COVID-19 could be leading to an excess of sloppy work, a computer scientist who develops automated programs to spot duplicate images in research papers is running his software across the world’s coronavirus preprints. So far, his efforts have yielded mixed success and some controversy.
[Nature News]
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Immune Status Is Prognostic for Poor Survival in Colorectal Cancer Patients and Is Associated with Tumor Hypoxia

Overall survival by immune and immune-checkpoint biomarkers in independent colorectal cancer cohorts was evaluated. Matched mutational and transcriptomic data were interrogated to identify associated biology.
[British Journal of Cancer]
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Single-Cell Transcriptomics Reveals Regulators Underlying Immune Cell Diversity and Immune Subtypes Associated with Prognosis in Nasopharyngeal Carcinoma

Investigators revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells. Diverse immune cell subtypes were identified, including novel subtypes such as CLEC9A+ dendritic cells
[Cell Research]
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Prognostic Impact of CD73 Expression and Its Relationship to PD-L1 in Patients with Radically Treated Pancreatic Cancer

Tissue microarray blocks were constructed and stained immunohistochemically using CD73 antibody. Staining intensity and numbers of stained tumor cells, inflammatory cells, stroma, and blood vessels were assessed.
[Virchows Archiv]
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The NK Cell–Cancer Cycle: Advances and New Challenges in NK Cell–Based Immunotherapies

Scientists introduce the NK cell–cancer cycle to highlight recent advances in NK cell biology and to discuss the progress and problems of NK cell–based cancer immunotherapies.
[Nature Immunology]
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