‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT]
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Optimized Ex Vivo Stimulation Identifies Multi-Functional HBV-Specific T Cells in a Majority of Chronic Hepatitis B Patients

Investigators modified the key variables of cell number and the peptide pulsing method to improve ex vivo detection of HBV-specific T cells.
[Scientific Reports]
Chua, C. G., Mehrotra, A., Mazzulli, T., Wong, D. K., Feld, J. J., Janssen, H. L. A., & Gehring, A. J. (2020). Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients. Scientific Reports, 10(1), 11344. https://doi.org/10.1038/s41598-020-68226-5 Cite
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The Intraprostatic Immune Environment after Stereotactic Body Radiotherapy Is Dominated by Myeloid Cells

Freshly resected prostate specimens were processed to obtain single-cell suspensions, and immune-phenotyped for major lymphoid and myeloid cell subsets by staining with two separate 14-antibody panels and multicolor flow cytometry analysis.
[Prostate Cancer and Prostatic Diseases]
Nickols, N. G., Ganapathy, E., Nguyen, C., Kane, N., Lin, L., Diaz-Perez, S., … Schaue, D. (2020). The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells. Prostate Cancer and Prostatic Diseases, 1–5. https://doi.org/10.1038/s41391-020-0249-8 Cite
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LRRK 2 Activation Controls the Repair of Damaged Endomembranes in Macrophages

Scientists showed that the Parkinson’s disease‐related kinase LRRK 2 was activated in macrophages by pathogen‐ or sterile‐induced endomembrane damage.
[EMBO Journal]
Herbst, S., Campbell, P., Harvey, J., Bernard, E. M., Papayannopoulos, V., Wood, N. W., … Gutierrez, M. G. (2020). LRRK2 activation controls the repair of damaged endomembranes in macrophages. The EMBO Journal, n/a(n/a), e104494. https://doi.org/10.15252/embj.2020104494 Cite
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Naproxen Chemoprevention Promotes Immune Activation in Lynch Syndrome Colorectal Mucosa

Investigators conducted a Phase Ib, placebo-controlled, randomised clinical trial of two dose levels of naproxen sodium administered daily for six months to 80 participants with Lynch syndrome (LS), and a co-clinical trial using a genetically engineered mouse model of LS and patient-derived organoids
[Gut]
Reyes-Uribe, L., Wu, W., Gelincik, O., Bommi, P. V., Francisco-Cruz, A., Solis, L. M., … Vilar, E. (2020). Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa. Gut. https://doi.org/10.1136/gutjnl-2020-320946 Cite
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‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science]
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US Bars International Students from Online-Only Learning in Fall

Since higher education institutions ended in-person classes in March due to the COVID-19 pandemic, there has been uncertainty over what classes will look like in the fall. Universities will soon have to come up with an answer.
[The Scientist]
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Cholesterol Metabolism Drives Regulatory B Cell IL-10 through Provision of Geranylgeranyl Pyrophosphate

Researchers demonstrated that the induction of a regulatory program in human B cells was dependent on a metabolic priming event driven by cholesterol metabolism.
[Nature Communications]
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An Optimist Takes the Helm at the National Science Foundation

The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists—who make up a sizeable share of the U.S. research enterprise—to enter the country.
[Science]
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A Novel Humanized Mouse Model to Study the Function of Human Cutaneous Memory T Cells In Vivo in Human Skin

Scientists utilized immunodeficient NOD-scid IL2rγnull (NSG) mice that carried in vivo-generated engineered human skin (ES). ES was generated from human keratinocytes and fibroblasts and was initially devoid of skin-resident immune cells.
[Scientific Reports]
Klicznik, M. M., Benedetti, A., Gail, L. M., Varkhande, S. R., Holly, R., Laimer, M., … Gratz, I. K. (2020). A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin. Scientific Reports, 10(1), 11164. https://doi.org/10.1038/s41598-020-67430-7 Cite
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Cabaletta Bio and Artisan Bio Announce Gene Editing Research and Collaboration Agreement to Develop Next-Generation CAAR T Cell Therapies

Cabaletta Bio, Inc. announced they have signed a research and collaboration agreement to accelerate development of next-generation CAAR T cell therapies for patients with B cell-mediated autoimmune diseases.
[Calbetta Bio, Inc.]
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