Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Uveal Melanoma Immunogenomics Predict Immunotherapy Resistance and Susceptibility

April 16, 2024

[Nature Communications] Scientists comprehensively profiled 100 human uveal melanoma metastases using clinicogenomics, transcriptomics, and tumor infiltrating lymphocyte potency assessment.

Single-Cell Profiling Reveals Kidney CD163+ Dendritic Cell Participation in Human Lupus Nephritis

April 16, 2024

[Annals Of The Rheumatic Diseases] Single-cell RNA and T cell receptor sequencing were performed on renal biopsy tissues from 40 patients with lupus nephritis and 6 healthy donors as controls. Matched peripheral blood samples from seven LN patients were also sequenced.

Immune Cell Composition and Inflammatory Profile of Human Peri-Implantitis and Periodontitis Lesions

April 16, 2024

[Clinical & Experimental Metastasis] Scientists assessed the immune cell composition of peri-implantitis and periodontitis lesions and the corresponding inflammatory profile in soft tissues and crevicular fluid. Peri-implantitis, periodontitis and control patients were recruited, and soft tissue biopsies were collected during surgery.

Single-Cell Characterisation of Tissue Homing CD4+ and CD8+ T Cell Clones in Immune-Mediated Refractory Arthritis

April 16, 2024

[Molecular Medicine] The authors investigated CD4+ and CD8+ T lymphocytes from the synovial tissue and peripheral blood of patients with treatment-resistant immune-mediated arthritis using paired single-cell RNA and TCR-sequencing.

Construction of a Prognostic Model Based on Memory CD4+ T Cell–Associated Genes for Lung Adenocarcinoma and Its Applications in Immunotherapy

April 16, 2024

[CPT-Pharmacometrics & Systems Pharmacology] Weighted gene coexpression network analysis helped identify memory CD4+ T cell–associated gene modules. Combined with module genes, a five-gene lung adenocarcinoma prognostic risk model was constructed by regression analysis.

ERC Advanced Grant for Cutting-Edge Research on the Cell’s Immune Response

April 16, 2024

[Goethe University Frankfurt (EurekAlert!)] Biochemist and structural biologist Robert Tampé, a specialist in the structural analysis of membrane protein complexes of the adaptive immune system, has now been awarded a five-year, €2.5 million European Research Council Advanced Grant for his project Unraveling the Supramolecular Architecture of Molecular Machineries in Adaptive Immunity

When Will Patients See Personalized Cancer Vaccines?

April 16, 2024

[Harvard Medical Soon] Sooner than you may think, says Dr. Catherie Wu, Harvard Medical School professor of medicine and, was honored in February with the $1 million Sjöberg Prize, given for cancer research.

Neoantigen-Targeted Dendritic Cell Vaccination in Lung Cancer Patients Induces Long-Lived T Cells Exhibiting the Full Differentiation Spectrum

April 15, 2024

[Cell Reports] Investigators presented the results of a Phase I clinical trial in which a dendritic cell vaccine targeting patient-individual neoantigens is evaluated in patients with resected non-small cell lung cancer.

Tissue-Specific Nonheritable Influences Drive Endometrial Immune System Variation

April 11, 2024

[Science Immunology] To assess uterine immune system variation, investigators performed a system-level analysis of endometrial and peripheral blood immune cells in monozygotic twins.

Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma

April 11, 2024

[American Journal Of Respiratory And Critical Care Medicine] Researchers investigated the effect of NMU/NMUR1 axis on early activation of group 2 innate lymphoid cells in asthma. Mild asthmatics were enrolled in a diluent-controlled, allergen-inhalation challenge study.

Essential Pharma Acquires Renaissance Pharma Ltd with Its Clinical Stage Immunotherapy for the Treatment of High-Risk Neuroblastoma

April 10, 2024

[Essential Pharma] Essential Pharma announced that it has completed the acquisition of the entire issued share capital of Renaissance Pharma Ltd. Renaissance Pharma is a clinical stage pharmaceutical company focused on the development of life changing therapies in pediatric rare disease.

Immunological Aspects of Central Neurodegeneration

April 9, 2024

[Cell Discovery] Scientists critically discuss immunological mechanisms of central neurodegeneration and propose potential strategies to correct neurodegeneration-associated immunological dysfunction with therapeutic purposes.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.