DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25

Investigators showed that neutrophil extracellular traps (NETs) were abundant in the liver metastases of patients with breast and colon cancers, and that serum NETs could predict the occurrence of liver metastases in patients with early-stage breast cancer.
[Nature]
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A Variant in IL6ST with a Selective IL-11 Signaling Defect in Human and Mouse

Researchers characterized the impact of a variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and supported these findings using a mouse model with the corresponding genome-edited variant Il6st p.R279Q.
[Bone Research]
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convertibleCARs: A Chimeric Antigen Receptor System for Flexible Control of Activity and Antigen Targeting

An inert form of the human NKG2D extracellular domain (iNKG2D) was engineered as the ectodomain of the chimeric antigen receptor (CAR) to generate convertibleCARTM-T cells. These cells were specifically directed to kill antigen-expressing target cells only in the presence of an activating bispecific adapter comprised of an iNKG2D-exclusive ULBP2-based ligand fused to an antigen-targeting antibody
[Communications Biology]
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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Investigators summarize and question what is known and remains to be discovered about the TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.
[Cell]
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Old Dogs, New Trick: Classic Cancer Therapies Activate cGAS

The authors review the antitumor roles of the GMP-AMP synthase (cGAS-STING) pathway during tumorigenesis, cancer immune surveillance, and cancer therapies. They also highlight classic cancer therapies that elicit antitumor immune responses through cGAS activation.
[Cell Research]
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Pro-Lymphangiogenic VEGFR-3 Signaling Modulates Memory T Cell Responses in Allergic Airway Inflammation

Researchers explored how pro-lymphangiogenic signaling affects the allergic response to house dust mite. In the acute inflammatory phase, the lungs of mice treated with blocking antibodies against VEGFR-3 displayed less inflammation overall, with dramatically reduced innate and T-cell numbers and reduced inflammatory chemokine levels.
[Mucosal Immunology]
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CX3CL1 Homo-Oligomerization Drives Cell-to-Cell Adherence

The analysis of CX3CL1 clusters using native electrophoresis and single molecule fluorescence kinetics showed that CX3CL1 was a homo-oligomer of 3 to 7 monomers. Fluorescence recovery after photobleaching assays revealed that the CX3CL1-transmembrane domain peptide self-associated in both cellular and acellular lipid environments, while its random counterpart did not.
[Scientific Reports]
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City of Hope Signs Licensing Agreement with Scopus BioPharma Inc. to Develop Novel, Targeted Immuno-Oncology Gene Therapy

City of Hope have signed an exclusive, worldwide licensing agreement with Scopus BioPharma Inc. Scopus will further develop and plans to commercialize a City of Hope first-in-class, targeted immuno-oncology gene therapy.
[City of Hope]
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