Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis

Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America]
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Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Nonexposed Mucosal Organs and Primes for Allergic Inflammation

Researchers investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs.
[Mucosal Immunology]
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Protein Kinase C Theta Modulates PCMT1 through hnRNPL to Regulate FOXP3 Stability in Regulatory T Cells

Scientists explored how using a synthetic cell-penetrating peptide mimic for intracellular anti-protein kinase C theta delivery fine-tuned differentiation of induced regulatory T cells, through its differential effects on RNA processing.
[Molecular Therapy]
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Increasing Serotonin Bioavailability Alters Gene Expression in Peripheral Leukocytes and Lymphoid Tissues of Dairy Calves

Investigators established that bovine peripheral leukocytes express all known serotonin receptors, and can synthesize, uptake and degrade serotonin due to the expression of serotonin metabolism-related genes.
[Scientific Reports]
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Distribution of Nerve Fibers and Nerve-Immune Cell Association in Mouse Spleen Revealed by Immunofluorescent Staining

Scientists demonstrated extensive nerve fibers in all splenic compartments including the splenic nodules, periarteriolar lymphoid sheath, marginal zones, trabeculae, and red pulp; close associations of nerve fibers with blood vessels; and close associations of nerve fibers with various subsets of dendritic cells, macrophages, and lymphocytes
[Scientific Reports]
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Vagus Nerve Stimulation Even after Injury Ameliorates Cisplatin-Induced Nephropathy via Reducing Macrophage Infiltration

To explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.
[Scientific Reports]
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Activation of GPR35 Protects against Cerebral Ischemia by Recruiting Monocyte-Derived Macrophages

The flowcytometric analysis shows the expression of G protein coupled receptor 35 (GPR35) on the infiltrating monocytes/macrophages and neutrophils in the ischemic brain.
[Scientific Reports]
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Generation of Knockout Rabbits with X-linked Severe Combined Immunodeficiency (X-SCID) Using CRISPR/Cas9

X-SCID rabbits presented immunodeficient phenotypes including the loss of T and B cells and hypoplasia of the thymus.
[Scientific Reports]
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Apatinib Prevents Natural Killer Cell Dysfunction to Enhance the Efficacy of Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma

Using a syngeneic hepatoceullar carcinoma (HCC) mouse model, the authors demonstrated that treatment with apatinib resulted in attenuation of tumor growth and increased tumor vessel normalization. Results indicated that NK cells, but not CD4+ or CD8+ T cells mediated the therapeutic efficacy of apatinib in HCC mouse models.
[Cancer Gene Therapy]
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The Contribution from Interleukin-27 towards Rheumatoid Inflammation: Insights from Gene Expression

The authors assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity]
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Determinants of Resident Tissue Macrophage Identity and Function

The authors review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.
[Immunity]
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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]
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