Immunology of Infectious Diease News

Arginine Ingestion Inhibits Phagocyte Invasion in Eccentrically Contracted Rat Fast-Twitch Muscle

[Journal of Muscle Research and Cell Motility] Scientists investigated whether prior ingestion of L-arginine, a nitric oxide precursor, inhibited eccentric contraction-induced macrophage invasion.

KLF13 Promotes VSMCs Phenotypic Dedifferentiation by Directly Binding to the SM22α Promoter

[Journal of Cellular Physiology] The authors investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE−/− mice.

Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension

[Circulation Research] Researchers studied cyclophilin D (CypD) acetylation in patients with essential hypertension, defined a pathogenic role of CypD acetylation in deacetylation mimetic CypD-K166R mutant mice and endothelial-specific general control of amino acid synthesis 5 like 1–deficient mice using an angiotensin II model of hypertension.

Ohwia caudata Aqueous Extract Attenuates Senescence in Aging Adipose-Derived Mesenchymal Stem Cells

[Heliyon] Using 0.1 μM doxorubicin, investigators induced aging in human adipose-derived MSCs and evaluated whether various concentrations of O. caudata aqueous extract exhibited anti-aging effects on them.

Tbl1 Promotes Wnt/β-Catenin Signaling-Induced Degradation of the Tcf7l1 Protein in Mouse ESCs

[Journal of Cell Science] Investigators showed that the overexpression of transducin-β-like protein 1 (Tbl1) or its family member Tblr1 could decrease Tcf7l1 protein levels, while the knockdown of each increased Tcf7l1 levels without affecting Tcf7l1 transcription.

Dynamic Roles of Signaling Pathways in Maintaining Pluripotency of Mouse and Human Embryonic Stem Cells

[Cellular Reprogramming] The authors discuss the role of canonical signaling pathways implicated in regulation of pluripotency and differentiation particularly in mouse and human ESCs.

Neuroendocrine Cells Initiate Protective Upper Airway Reflexes

[Science] Scientists showed that murine neuroendocrine cells in the healthy lung, trachea, and larynx had distinct biophysical properties but shared sensitivity to two commonly aspirated noxious stimuli, water, and acid.

PARP-ish: Gaps in Molecular Understanding and Clinical Trials Targeting PARP Exacerbate Racial Disparities in Prostate Cancer

[Cancer Research] Investigators explore PARP nuclear functions, inhibition, and clinical relevance through the lens of racial differences.

Hepatic Signal Transducer and Activator of Transcription-3 signaling Drives Early-Stage Pancreatic Cancer Cachexia via Suppressed Ketogenesis

[Journal Of Cachexia Sarcopenia And Muscle] Researchers establishes a direct link between skeletal muscle homeostasis and hepatic metabolism. Dietary and anti-inflammatory interventions that restored ketogenesis may be a viable preventative approach for pre-cachectic patients with pancreatic cancer.

Monitoring Hepatocellular Carcinoma Using Tumor Content in Circulating Cell-Free DNA

[Clinical Cancer Research] Scientists evaluated the utility of tumor content in circulating cell-free DNA for monitoring HCC throughout its natural history. They included 67 hepatitis B virus-related HCC patients, of whom 17 had paired pre- and post-treatment samples, and 90 controls.

Notch1 Regulates Hepatic Thrombopoietin Production

[Blood] Investigators noted thrombocytopenia in mice with hepatic Notch1 deficiency, and so investigated thrombopoietin production and other features of platelets in mice. They found that the liver ultrastructure and hepatocyte function were comparable between control mice and Notch1-deficient mice.

ER Stress Signaling at the Interphase Between MASH and Hepatocellular Carcinoma

[Hepatology] The authors propose that chronic endoplasmic reticulum stress is a common transversal factor contributing to the transition from liver disease to HCC. Interventional strategies to target the unfolded protein response in HCC as cancer therapy are also discussed.
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