Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

A Molnupiravir-Associated Mutational Signature in Global SARS-CoV-2 Genomes

September 26, 2023

[Nature] Scientists showed that SARS-CoV-2 sequencing databases contain extensive evidence of molnupiravir mutagenesis.

Baseline Gut Microbiota and Metabolome Predict Durable Immunogenicity to SARS-CoV-2 Vaccines

September 26, 2023

[Signal Transduction And Targeted Therapy] Investigators collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline, 1 month, and 6 months post-vaccination. They identified potential microbiota-based adjuvants that may extend the durability of immune responses to SARS-CoV-2 vaccines.

A Computationally Designed Antigen Eliciting Broad Humoral Responses Against SARS-CoV-2 and Related Sarbecoviruses

September 26, 2023

[Nature Biomedical Engineering] Researchers showed that a single antigen based on the receptor binding domain of the spike protein of sarbecoviruses elicits broad humoral responses against SARS-CoV-1, SARS-CoV-2, WIV16 and RaTG13 in mice, rabbits and guinea pigs.

Previous Infection with Seasonal Coronaviruses Does Not Protect Male Syrian Hamsters from Challenge with SARS-CoV-2

September 26, 2023

[Nature Communications] Hamsters were initially inoculated with seasonal coronaviruses, or SARS-CoV-2 pango B lineage virus, then challenged with SARS-CoV-2 pango B lineage virus, or SARS-CoV-2 variants Beta or Omicron.

Green Synthesis, Characterization, Anti-SARS-CoV-2 Entry, and Replication of Lactoferrin-Coated Zinc Nanoparticles with Halting Lung Fibrosis Induced in Adult Male Albino Rats

September 26, 2023

[Scientific Reports] Lactoferrin zinc nanoparticles showed potent in vitro retardation for SARS-CoV-2 entry to host cells by binding to the ACE2-receptor and spike protein receptor binding domain at IC50 values of 59.66 and μg/mL, respectively.

Initial Productive and Latent HIV Infections Originate In Vivo by Infection of Resting T Cells

September 26, 2023

[Journal Of Clinical Investigation] Productively and latently HIV-infected cells could originate by direct infection of resting CD4+ T cell populations in lymphoid tissues in Fiebig I, the earliest stage of detectable HIV infection.

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling Following Respiratory Viral Infection

September 26, 2023

[Nature Communications] Researchers showed that a subset of distal airway secretory cells, intralobar serous cells, were activated to assume basal cell fates following influenza virus infection.

Chimeric Hemagglutinin Split Vaccines Elicit Broadly Cross-Reactive Antibodies and Protection Against Group 2 Influenza Viruses in Mice

September 26, 2023

[Science Advances] Scientists showed that immunization with group 2 chimeric HA split vaccines in combination with the CpG 1018 adjuvant elicits broadly cross-reactive antibodies against all group 2 HAs, as well as systemic and local antigen-specific T cell responses.

Self-Assembled Virus-Like Particle Vaccines via Fluorophilic Interactions Enable Infection Mimicry and Immune Protection

September 26, 2023

[Advanced Healthcare Materials] A novel virus-like particle platform was developed that could mimic infection and confer influenza protection through fluorination-driven self-assembly.

The Role of Cell Death in SARS-CoV-2 Infection

September 26, 2023

[Signal Transduction And Targeted Therapy] The authors summarize the existing evidence concerning the molecular modulation of cell death in SARS-CoV-2 infection as well as viral-host interactions, which may shed new light on antiviral therapy against SARS-CoV-2.

BioNTech Secures $90M from CEPI to Partner on Mpox Vaccine As It Enters Clinic

September 26, 2023

[Fierce Biotech] The German biotech is partnering with the Center for Epidemic Preparedness Innovations, accepting up to $90 million from the foundation as part of a broader pandemic preparation initiative.

COVID Vaccines Linked to Unexpected Vaginal Bleeding

September 26, 2023

[Nature] Women who don’t menstruate — including postmenopausal women and those on contraceptives — were several times more likely to experience unexpected vaginal bleeding after COVID-19 vaccination than before the vaccines were offered, a study finds.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.