Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

Vaccination Reduces Central Nervous System IL-1β and Memory Deficits After COVID-19 in Mice

[Nature Immunology] Investigators showed that intranasal infection of C57BL/6J mice with SARS-CoV-2 Beta variant led to central nervous system infiltration of Ly6Chi monocytes and microglial activation.

Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis

[American Journal of Respiratory and Critical Care Medicine] To explore the composition of the lung bacterial microbiome and its association with viral and fungal infection, immunity and outcome in severe influenza versus COVID-19 with or without aspergillosis.

Antibody and T-cell Response to Bivalent Booster SARS-CoV-2 Vaccines in People with Compromised Immune Function (COVERALL-3)

[Journal of Infectious Diseases] Researchers assessed the immune response in previously vaccinated individuals of the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study following bivalent mRNA vaccination. Eligible participants received approved bivalent mRNA SARS-CoV-2 vaccines within their clinical routine.

Human SARS-CoV-2 Challenge Uncovers Local and Systemic Response Dynamics

[Nature] In this SARS-CoV-2 human challenge study, researchers used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, transient and sustained infections in seronegative individuals challenged with pre-Alpha SARS-CoV-2.

T-Cell Immunity Induced and Reshaped by an Anti-HPV Immuno-Oncotherapeutic Lentiviral Vector

[NPJ Vaccines] Investigators established that anti-vector immunity induced by Lenti-HPV-07 prime had no impact on the efficacy of a homologous boost to amplify anti-HPV T cell immunity.

ATG10S Promotes IFNL1 Expression and Autophagic Degradation of Multiple Viral Proteins Mediated by IFNL1

[Autophagy] Scientists investigated the mechanism of ATG10S cooperation with IFNL1 to degrade viral proteins from different viruses. They explored the antiviral mechanism of ATG10S interaction with type III interferon and provided a theoretical basis for the development of ATG10S into a new broad-spectrum antiviral protein drug.

Type I Interferon Exacerbates Mycobacterium tuberculosis Induced Human Macrophage Death

[EMBO Reports] Monocyte-derived macrophages (MDM) prepared by a conventional method markedly upregulate interferon-stimulated genes upon Mycobacterium tuberculosis (Mtb) infection, while MDM prepared to better restrict Mtb do so much less.

Distinct SIV-Specific CD8+ T Cells in the Lymph Node Exhibit Simultaneous Effector and Stem-Like Profiles and Are Associated with Limited SIV Persistence

[Nature Immunology] Scientists identified an antigen-responsive TOXhiTCF1+CD39+CD8+ T cell population with high expression of inhibitory receptors and low expression of canonical cytolytic molecules.

Durability of Immune Responses to SARS-CoV-2 Infection and Vaccination

[Seminars In Immunology] The authors highlight their understanding the infection- and vaccine-mediated humoral, B and T cell responses, the durability of the immune responses, and how variants continue to threaten the efficacy of SARS-CoV-2 vaccines.

Teplensky Earns Beckman Young Investigator Award for Promising Vaccine Research

[Boston University] Assistant Professor Michelle Teplensky was named one of the 2024 Beckman Young Investigators. She and her team will receive $600,000 over four years to engineer versatile vaccine responses through nanomaterial design, with implications for the treatment of not only the flu but also other infectious diseases including the viruses that cause COVID-19, HIV, and more.

What Causes Long COVID? Case Builds for Rogue Antibodies

[Nature] Antibodies isolated from people with long COVID increase pain sensitivity and reduce movement in mice when transferred to the animals, research shows. The findings suggest that antibodies might drive some symptoms of long COVID — although how that process works is unclear, and the results will need to be replicated in larger studies.

National Academies Issue New Broad Definition of Long COVID

[Medscape] A new broadly inclusive definition of long COVID from the National Academies of Sciences, Engineering, and Medicine (NASEM) has been developed with the aim of improving consistency, documentation, and treatment for both adults and children.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.

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