Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

A Molnupiravir-Associated Mutational Signature in Global SARS-CoV-2 Genomes

[Nature] Scientists showed that SARS-CoV-2 sequencing databases contain extensive evidence of molnupiravir mutagenesis.

Baseline Gut Microbiota and Metabolome Predict Durable Immunogenicity to SARS-CoV-2 Vaccines

[Signal Transduction And Targeted Therapy] Investigators collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline, 1 month, and 6 months post-vaccination. They identified potential microbiota-based adjuvants that may extend the durability of immune responses to SARS-CoV-2 vaccines.

A Computationally Designed Antigen Eliciting Broad Humoral Responses Against SARS-CoV-2 and Related Sarbecoviruses

[Nature Biomedical Engineering] Researchers showed that a single antigen based on the receptor binding domain of the spike protein of sarbecoviruses elicits broad humoral responses against SARS-CoV-1, SARS-CoV-2, WIV16 and RaTG13 in mice, rabbits and guinea pigs.

Previous Infection with Seasonal Coronaviruses Does Not Protect Male Syrian Hamsters from Challenge with SARS-CoV-2

[Nature Communications] Hamsters were initially inoculated with seasonal coronaviruses, or SARS-CoV-2 pango B lineage virus, then challenged with SARS-CoV-2 pango B lineage virus, or SARS-CoV-2 variants Beta or Omicron.

Green Synthesis, Characterization, Anti-SARS-CoV-2 Entry, and Replication of Lactoferrin-Coated Zinc Nanoparticles with Halting Lung Fibrosis Induced in Adult Male Albino Rats

[Scientific Reports] Lactoferrin zinc nanoparticles showed potent in vitro retardation for SARS-CoV-2 entry to host cells by binding to the ACE2-receptor and spike protein receptor binding domain at IC50 values of 59.66 and μg/mL, respectively.

Initial Productive and Latent HIV Infections Originate In Vivo by Infection of Resting T Cells

[Journal Of Clinical Investigation] Productively and latently HIV-infected cells could originate by direct infection of resting CD4+ T cell populations in lymphoid tissues in Fiebig I, the earliest stage of detectable HIV infection.

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling Following Respiratory Viral Infection

[Nature Communications] Researchers showed that a subset of distal airway secretory cells, intralobar serous cells, were activated to assume basal cell fates following influenza virus infection.

Chimeric Hemagglutinin Split Vaccines Elicit Broadly Cross-Reactive Antibodies and Protection Against Group 2 Influenza Viruses in Mice

[Science Advances] Scientists showed that immunization with group 2 chimeric HA split vaccines in combination with the CpG 1018 adjuvant elicits broadly cross-reactive antibodies against all group 2 HAs, as well as systemic and local antigen-specific T cell responses.

Self-Assembled Virus-Like Particle Vaccines via Fluorophilic Interactions Enable Infection Mimicry and Immune Protection

[Advanced Healthcare Materials] A novel virus-like particle platform was developed that could mimic infection and confer influenza protection through fluorination-driven self-assembly.

The Role of Cell Death in SARS-CoV-2 Infection

[Signal Transduction And Targeted Therapy] The authors summarize the existing evidence concerning the molecular modulation of cell death in SARS-CoV-2 infection as well as viral-host interactions, which may shed new light on antiviral therapy against SARS-CoV-2.

BioNTech Secures $90M from CEPI to Partner on Mpox Vaccine As It Enters Clinic

[Fierce Biotech] The German biotech is partnering with the Center for Epidemic Preparedness Innovations, accepting up to $90 million from the foundation as part of a broader pandemic preparation initiative.

COVID Vaccines Linked to Unexpected Vaginal Bleeding

[Nature] Women who don’t menstruate — including postmenopausal women and those on contraceptives — were several times more likely to experience unexpected vaginal bleeding after COVID-19 vaccination than before the vaccines were offered, a study finds.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.