‘Has it peaked? I don’t know.’ NIH Official Details Foreign Influence Probe

Four years after the National Institutes of Health (NIH) began to investigate grantees who it believed had failed to disclose their ties to foreign governments, officials still don’t know the full extent of the problem.
[ScienceInsider]
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Drug Recently Shown to Reduce Coronavirus Death Risk Could Run Out, Experts Warn

A report that dexamethasone, a commonly used corticosteroid, reduces death rates of COVID-19 by up to one-third was greeted with enthusiasm around the globe. It also raised a question: Will there be enough of the medication?
[ScienceInsider]
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Coronavirus Misinformation, and How Scientists Can Help to Fight It

Scientists are well placed to help to hold back the tide of COVID-19 misinformation — but should they get involved in time-consuming, and sometimes bruising, efforts to do so, or just stick to doing good research?
[Nature News]
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Human MAIT Cell Cytolytic Effector Proteins Synergize to Overcome Carbapenem Resistance in Escherichia coli

Scientists showed that mucosa-associated invariant T (MAIT) cells mediate MR1-restricted antimicrobial activity against Escherichia coli clinical strains in a manner dependent on the activity of cytolytic proteins but independent of production of pro-inflammatory cytokines or induction of apoptosis in infected cells.
[PLoS Biology]
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Restoring Glucose Uptake Rescues Neutrophil Dysfunction and Protects against Systemic Fungal Infection in Mouse Models of Kidney Disease

Researchers showed in multiple models that uremic mice exhibited an increased susceptibility to systemic fungal infection. Uremia inhibited Glut1-mediated uptake of glucose in neutrophils by causing aberrant activation of GSK3β, resulting in reduced ROS generation and hence impaired killing of C. albicans in mice.
[Science Translational Medicine]
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Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections

Researchers studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT–PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 days and during hospitalization.
[Nature Medicine]
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

Researchers found that the monoclonal antibody CR3022 bound the receptor binding domain (RBD) tightly, neutralizing SARS-CoV-2 and report the crystal structure at 2.4 Å of the Fab/RBD complex.
[Cell Host & Microbe]
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COVID-19 Revisiting Inflammatory Pathways of Arthritis

The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signaling via Janus kinase inhibition in the treatment of COVID-19.
[Nature Reviews Rheumatology]
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Mucosal-Associated Invariant T (MAIT) Cells Provide B-Cell Help in Vaccinated and Subsequently SIV-Infected Rhesus Macaques

Scientists investigated MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage following mucosal adenovirus-SIV recombinant priming, intramuscular SIV envelope boosting and infection following repeated low-dose intravaginal SIV exposures.
[Scientific Reports]
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T-Cell Responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients

Investigators evaluated the CD4+ and CD8+ responses to influenza A and B infection in a cohort of solid organ transplant patients.
[Scientific Reports]
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Peripherally Induced Brain Tissue–Resident Memory CD8+ T Cells Mediate Protection against CNS Infection

Researchers showed that peripheral infections generated antigen-specific CD8+ memory T cells in the brain that adopted a unique tissue resident memory signature.
[Nature Immunology]
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