The Microbiota in Pneumonia: From Protection to Predisposition

The authors discuss how the healthy microbiota protects against pneumonia and how host factors and medical interventions alter the microbiota, thus influencing susceptibility to pneumonia.
[Science Translational Medicine]
The microbiota in pneumonia: From protection to predisposition | Science Translational Medicine. (n.d.). Retrieved January 18, 2021, from https://stm.sciencemag.org/content/13/576/eaba0501 Cite
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Scientists summarize existing data on the replication of SARS-CoV-2 in different tissues in both patients and ex vivo models.
[Clinical Microbiology Reviews]
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection | Clinical Microbiology Reviews. (n.d.). Retrieved January 18, 2021, from https://cmr.asm.org/content/34/2/e00133-20 Cite
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Local Immune Response to Food Antigens Drives Meal-Induced Abdominal Pain

Scientists showed that a bacterial infection and bacterial toxins could trigger an immune response that led to the production of dietary-antigen-specific IgE antibodies in mice, which were limited to the intestine.
[Nature]
Aguilera-Lizarraga, J., Florens, M. V., Viola, M. F., Jain, P., Decraecker, L., Appeltans, I., Cuende-Estevez, M., Fabre, N., Van Beek, K., Perna, E., Balemans, D., Stakenborg, N., Theofanous, S., Bosmans, G., Mondelaers, S. U., Matteoli, G., Ibiza Martínez, S., Lopez-Lopez, C., Jaramillo-Polanco, J., … Boeckxstaens, G. E. (2021). Local immune response to food antigens drives meal-induced abdominal pain. Nature, 1–6. https://doi.org/10.1038/s41586-020-03118-2 Cite
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Impact of Placental Malaria on Maternal, Placental and Fetal Cord Responses and Its Role in Pregnancy Outcomes in Women from Blue Nile State, Sudan

Malaria infection in the collected maternal peripheral, placental, umbilical cord samples was determined microscopically, and ELISA was used to measure the plasma levels IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples.
[Malaria Journal]
Omer, S., Franco-Jarava, C., Noureldien, A., Omer, M., Abdelrahim, M., Molina, I., & Adam, I. (2021). Impact of placental malaria on maternal, placental and fetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan. Malaria Journal, 20(1), 35. https://doi.org/10.1186/s12936-021-03580-x Cite
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Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro

The authors stimulated freshly isolated umbilical blood mononuclear cells with lysates of E. faecalis, S. agalacticae, and S. aureus collected from pregnant women in preterm labor.
[International Journal of Molecular Sciences]
Reuschel, E., Toelge, M., Haeusler, S., Deml, L., Seelbach-Goebel, B., & Solano, M. E. (2021). Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro. International Journal of Molecular Sciences, 22(1), 332. https://doi.org/10.3390/ijms22010332 Cite
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Roche Confirms US Government Agreement To Purchase Additional Doses of Regeneron’s Casirivimab and Imdevimab

Roche confirmed that the US Department of Health and Human Services and the Department of Defense will purchase additional supply of Regeneron’s casirivimab and imdevimab antibody cocktail for use in non-hospitalised COVID-19 patients as part of Operation Warp Speed.
[Roche (Globe Newswire, Inc.)]
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Gilead and Vir Biotechnology Establish Clinical Collaboration to Explore Combination Strategies for Functional Cure for Chronic Hepatitis B Virus

Gilead Sciences, Inc. and Vir Biotechnology, Inc. announced that the companies have entered into a clinical collaboration to evaluate novel therapeutic combination strategies aimed at developing a functional cure for chronic hepatitis B virus.
[Gilead Sciences, Inc. (BusinessWire, Inc)]
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AvantGen Announces Licensing of Its Anti-SARS-CoV-2 Antibodies to IGM Biosciences for COVID-19 Therapy Development

AvantGen, Inc. announced licensing of a panel of its anti-SARS-CoV-2 antibody clones to IGM Biosciences for COVID-19 therapy development.
[AvantGen, Inc. (BusinessWire, Inc)]
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US FDA Accepts for Priority Review the Biologics License Application for V114, Merck’s Investigational 15-valent Pneumococcal Conjugate Vaccine, for Use in Adults 18 Years of Age and Older

Merck announced the FDA accepted for priority review a Biologics License Application for V114, Merck’s investigational 15-valent pneumococcal conjugate vaccine, for the prevention of invasive pneumococcal disease in adults 18 years of age and older.
[Merck (BusinessWire, Inc)]
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A Therapeutic Neutralizing Antibody Targeting Receptor Binding Domain of SARS-CoV-2 Spike Protein

Researchers screened human monoclonal antibodies targeting the receptor binding domain of the viral spike protein via antibody library constructed from peripheral blood mononuclear cells of a convalescent patient.
[Nature Communications]
Kim, C., Ryu, D.-K., Lee, J., Kim, Y.-I., Seo, J.-M., Kim, Y.-G., Jeong, J.-H., Kim, M., Kim, J.-I., Kim, P., Bae, J. S., Shim, E. Y., Lee, M. S., Kim, M. S., Noh, H., Park, G.-S., Park, J. S., Son, D., An, Y., … Lee, S.-Y. (2021). A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein. Nature Communications, 12(1), 288. https://doi.org/10.1038/s41467-020-20602-5 Cite
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Adaptive immunity to SARS-CoV-2 and COVID-19

More studies reveal that CD4+ T cells, CD8+ T cells, and neutralizing antibodies all contribute to control of SARS-CoV-2, in both non-hospitalized and hospitalized cases of COVID-19. The specific functions and kinetics of these adaptive immune responses are discussed.
[Cell]
Sette, A., & Crotty, S. (2021). Adaptive immunity to SARS-CoV-2 and COVID-19. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.01.007 Cite
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