Metabolic Reprogramming by Zika Virus Provokes Inflammation in Human Placenta

Scientists showed, using large scale metabolomics, that ZIKV infection reprogrammed placental lipidome by impairing the lipogenesis pathways. ZIKV-induced metabolic alterations provided building blocks for lipid droplet biogenesis and intracellular membrane rearrangements to support viral replication.
[Nature Communications]
Abstract
Bookmark

No account yet? Register

0
Share

Mesenchymal Stem Cells Offer a Drug-Tolerant and Immune-Privileged Niche to Mycobacterium tuberculosis

Investigators report that mesenchymal stem cells (MSCs) sheltered Mybacterium tuberculosis (Mtb) to help tolerate anti-TB drugs. MSCs readily took up Mtb and allowed unabated mycobacterial growth despite having a functional innate pathway of phagosome maturation.
[Nature Communications]
Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis | Nature Communications. (n.d.). Retrieved June 17, 2020, from https://www.nature.com/articles/s41467-020-16877-3 Cite
Abstract
Bookmark

No account yet? Register

0
Share

TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis

Leishmania-infected Tlr7−/− mice developed a chronic unhealing lesion, despite Th1 cell differentiation, and scientists showed that Tlr7−/− neutrophils alone mediated this effect. Conversely, topical treatment with a TLR7 agonist early in infection induced smaller lesion development than in untreated mice.
[Cell Reports]
Regli, I. B., Passelli, K., Martínez-Salazar, B., Amore, J., Hurrell, B. P., Müller, A. J., & Tacchini-Cottier, F. (2020). TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis. Cell Reports, 31(10). https://doi.org/10.1016/j.celrep.2020.107746 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Shedding of Brucella melitensis Happens through Milk Macrophages in the Murine Model of Infection

Pregnant Balb/cByJ mice were intraperitoneally infected with 105 CFU of the 16 M reference strain, a 16 M mCherry mutant or a human isolate. Milk was collected over the course of lactation, and subjected to culture and immunofluorescence assays.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

Protection of Layers and Breeders against Homologous or Heterologous HPAIv by Vaccines from Korean National Antigen Bank

Researchers evaluated the efficacy of the clade 2.3.2.1c and 2.3.4.4c H5Nx vaccines from the Korean avian influenza national antigen bank for emergency preparedness for their potency and protective efficacy against lethal homologous and heterologous viruses in layer and breeder chickens practically.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

Downregulation of HLA-I by the Molluscum Contagiosum Virus Mc080 Impacts NK-Cell Recognition and Promotes CD8+ T-Cell Evasion

MC080, but not MC033, downregulated cell-surface expression of endogenous classical human leucocyte antigen (HLA) class I and non-classical HLA-E by a transporter associated with antigen processing-independent mechanism.
[Journal of General Virology]
Full Article
Bookmark

No account yet? Register

0
Share

Influenza Virus-Induced Oxidized DNA Activates Inflammasomes

Investigators showed that influenza virus stimulated oxidized DNA release from macrophages. Ion channel activity of the M2 protein or mitochondrial localization of the PB1-F2 protein was required for oxidized DNA release.
[iScience]
AbstractFull ArticlePress Release
Bookmark

No account yet? Register

0
Share

From Threat to Cure: Understanding of Virus-Induced Cell Death Leads to Highly Immunogenic Oncolytic Influenza Viruses

The authors discuss strategies for targeting viral replication to cancerous lesions and arming them with immunogenic transgenes. They describe which modes of cell death are induced by influenza A virus infection and how these insights may be utilized to optimize influenza A virus-based oncolytic virus design.
[Cell Death Discovery]
Full Article
Bookmark

No account yet? Register

0
Share

Adamis Pharmaceuticals Announces License to Commercialize Tempol, a Novel Investigational Anti-inflammatory and Antioxidant Drug for the Treatment of Respiratory Diseases Including COVID-19

Adamis Pharmaceuticals Corporation announced a license to commercialize Tempol, a novel patented investigational drug for the treatment of COVID-19. The license includes the worldwide use of Tempol for the treatment of all respiratory diseases including asthma, respiratory syncytial virus, influenza and COVID-19.
[Adamis Pharmaceuticals]
Press Release
Bookmark

No account yet? Register

0
Share

Systemically Comparing Host Immunity between Survived and Deceased COVID-19 Patients

Scientists summarized the characteristics of cellular immune responses in a total of 157 COVID-19 patients enrolled in Tongji Hospital between February and March 2020 and compare the properties between 95 survived and 62 deceased patients with different onset time.
[Cellular & Molecular Immunology]
Full Article
Bookmark

No account yet? Register

0
Share

Pluristem Announces Activation of Clinical Sites and Commencement of Patient Enrollment in US FDA Phase II COVID-19 ARDS Trial

Pluristem Therapeutics, Inc. announced the activation of clinical sites and initiation of enrollment in its Phase II US FDA study of PLX cells for the treatment of severe COVID-19 complicated by Acute Respiratory Distress Syndrome (ARDS).
[Pluristem Therapeutics, Inc. ]
Graphical Abstract
Bookmark

No account yet? Register

0
Share
Share