Antibody Affinity Maturation and Plasma IgA Associate with Clinical Outcome in Hospitalized COVID-19 Patients

Scientists examined longitudinal plasma samples from hospitalized COVID-19 patients with differential clinical outcome.
[Nature Communications]
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The Antigenic Anatomy of SARS-CoV-2 Receptor Binding Domain

Scientists identified 377 human monoclonal antibodies recognizing the virus spike, and focused mainly on 80 that bind the receptor binding domain.
[Cell]
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Reduced Neutralization of SARS-CoV-2 B.1.1.7 Variant by Convalescent and Vaccine Sera

Scientists examined the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination.
[Cell]
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Coinfection with Influenza A Virus Enhances SARS-CoV-2 Infectivity

Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, scientists found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.
[Cell Research]
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Diffusion Pharmaceuticals Completes Phase Ib Study of TSC in Hospitalized COVID-19 Patients

Diffusion Pharmaceuticals, Inc. announced completion and topline data from the open-label, Phase Ib clinical trial of its novel, diffusion-enhancing therapeutic, trans sodium crocetinate, in hospitalized COVID-19 patients with confirmed hypoxemia, the most common cause of tissue hypoxia.
[Diffusion Pharmaceuticals, Inc.]
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Cross-Species RNA-Seq for Deciphering Host–Microbe Interactions

The authors summarize how next-generation RNA sequencing has become a primary technology to study host–microbe interactions with high resolution
[Nature Reviews Genetics]
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Ethics Approval Granted for Open Orphan’s COVID-19 Human Challenge Study Model

Open Orphan plc announced the world’s first COVID-19 characterization study has received approval from a specially convened Research Ethics Committee.
[Open Orphan plc (BusinessWire, Inc)]
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SCYNEXIS and Hansoh Pharma Announce Licensing Agreement and Strategic Partnership for Ibrexafungerp in Greater China

SCYNEXIS, Inc. and Hansoh Pharmaceutical Group Company Limited announced a strategic partnership and license agreement for the development and commercialization of Ibrexafungerp for the Greater China region.
[SCYNEXIS, Inc. (BusinessWire, Inc)]
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T Cell-Tropic HIV Efficiently Infects Alveolar Macrophages through Contact with Infected CD4+ T Cells

Scientists collected alveolar macrophages by bronchoscopy performed in HIV-infected, antiretroviral therapy-naive and uninfected subjects.
[Scientific Reports]
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Structural and Biophysical Correlation of Anti-NANP Antibodies with In Vivo Protection against P. falciparum

Scientists elucidated crystal structures, binding affinities and kinetics, and in vivo protection of eight anti-NANP antibodies derived from an RTS,S Phase IIa trial and encoded by three different heavy-chain germline genes.
[Nature Communications]
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Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment

Scientists hypothesized ICI resistance mutations in the IFNγ pathway would simultaneously render melanomas susceptible to oncolytic virus therapy.
[Clinical Cancer Research]
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