Cytoplasmic Short Linear Motifs in ACE2 and Integrin β3 Link SARS-CoV-2 Host Cell Receptors to Mediators of Endocytosis and Autophagy

Researchers measured the binding affinity of predicted interactions between short linear motifs in the cytoplasmic tails of angiotensin-converting enzyme 2 and integrin β3 with proteins that mediate endocytic trafficking and autophagy.
[Science Signaling]
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A Class of Viral Inducer of Degradation of the Necroptosis Adaptor RIPK3 Regulates Virus-Induced Inflammation

Using a targeted small interfering RNA screen, scientists identified a viral inhibitor found in cowpox virus and other orthopoxviruses that bound to the host SKP1-Cullin1-F-box machinery and the essential necroptosis kinase receptor interacting protein kinase 3.
[Immunity]
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Infection Trains the Host for Microbiota-Enhanced Resistance to Pathogens

Scientists showed that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to the expansion of taxa that utilize the sulfonic acid taurine.
[Cell]
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Vaccination Induces Maturation in a Mouse Model of Diverse Unmutated VRC01-Class Precursors to HIV-Neutralizing Antibodies With >50% Breadth

Using sequential immunization of immunoglobulin-humanized mice expressing diverse unmutated VRC01-class antibody precursors, scientists elicited serum responses capable of neutralizing viruses bearing glycan276 and isolated multiple lineages of VRC01-class bnAbs, including two with >50% breadth on a 208-strain panel.
[Immunity]
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Evolution of Antibody Immunity to SARS-CoV-2

Scientists report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection. They find that IgM, and IgG anti-SARS-CoV-2 spike protein receptor binding domain antibody titres decrease significantly with IgA being less affected.
[Nature]
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The Microbiota in Pneumonia: From Protection to Predisposition

The authors discuss how the healthy microbiota protects against pneumonia and how host factors and medical interventions alter the microbiota, thus influencing susceptibility to pneumonia.
[Science Translational Medicine]
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Scientists summarize existing data on the replication of SARS-CoV-2 in different tissues in both patients and ex vivo models.
[Clinical Microbiology Reviews]
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Local Immune Response to Food Antigens Drives Meal-Induced Abdominal Pain

Scientists showed that a bacterial infection and bacterial toxins could trigger an immune response that led to the production of dietary-antigen-specific IgE antibodies in mice, which were limited to the intestine.
[Nature]
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Impact of Placental Malaria on Maternal, Placental and Fetal Cord Responses and Its Role in Pregnancy Outcomes in Women from Blue Nile State, Sudan

Malaria infection in the collected maternal peripheral, placental, umbilical cord samples was determined microscopically, and ELISA was used to measure the plasma levels IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples.
[Malaria Journal]
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Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro

The authors stimulated freshly isolated umbilical blood mononuclear cells with lysates of E. faecalis, S. agalacticae, and S. aureus collected from pregnant women in preterm labor.
[International Journal of Molecular Sciences]
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Roche Confirms US Government Agreement To Purchase Additional Doses of Regeneron’s Casirivimab and Imdevimab

Roche confirmed that the US Department of Health and Human Services and the Department of Defense will purchase additional supply of Regeneron’s casirivimab and imdevimab antibody cocktail for use in non-hospitalised COVID-19 patients as part of Operation Warp Speed.
[Roche (Globe Newswire, Inc.)]
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