The Vascular Endothelium: The Cornerstone of Organ Dysfunction in Severe SARS-CoV-2 Infection

Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature.
[Critical Care]
Full Article
Bookmark

No account yet? Register

0
Share

Immune Status Could Determine Efficacy of COVID-19 Therapies

Emerging evidence suggests that SARS-CoV-2 can drive a diverse array of immune processes, raising the risk that immunosuppressant agents that are in clinical trials might be effective for some patients but detrimental for others.
[Nature Reviews Drug Discovery]
Press Release
Bookmark

No account yet? Register

0
Share

How Deadly Is the Coronavirus? Scientists Are Close to an Answer

Researchers use a metric called infection fatality rate (IFR) to calculate how deadly a new disease is. It is the proportion of infected people who will die as a result, including those who don’t get tested or show symptoms.
[Nature News]
Press Release
Bookmark

No account yet? Register

0
Share

‘We’ve Got to Be Able to Move More Quickly.’ The Pandemic Reality of COVID-19 Clinical Trials

With speed borne of desperation comes risk and confusion—of trials too small to yield answers, of treatments overhyped, and of uncertainty about how to design the best studies possible. Science spoke with three clinical trial experts about this unprecedented period for modern medical research.
[ScienceInsider]
Press Release
Bookmark

No account yet? Register

0
Share

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

Several of the cytokines involved in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs). JAK inhibition, therefore, presents an attractive therapeutic strategy for cytokine release syndrome, which is a common cause of adverse clinical outcomes in COVID-19.
[Trends in Pharmacological Sciences]
Luo, W., Li, Y.-X., Jiang, L.-J., Chen, Q., Wang, T., & Ye, D.-W. (2020). Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19. Trends in Pharmacological Sciences, 0(0). https://doi.org/10.1016/j.tips.2020.06.007 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Variations in Killer-Cell Immunoglobulin-Like Receptor and Human Leukocyte Antigen Genes and Immunity to Malaria

Understanding the role of killer-cell immunoglobulin-like receptors and human leukocyte antigens in immunity to malaria can help to better characterize antimalarial immune responses. The authors summarize the different KIRs and HLAs associated with immunity to malaria thus far.
[Cellular & Molecular Immunology]
Full Article
Bookmark

No account yet? Register

0
Share

FOXO1 Promotes HIV Latency by Suppressing ER Stress in T Cells

Researchers report that, in resting T cells, FOXO1 inhibition impaired autophagy and induced endoplasmic reticulum (ER) stress, thereby activating two associated transcription factors: activating transcription factor 4 and nuclear factor of activated T cells.
[Nature Microbiology]
Abstract
Bookmark

No account yet? Register

0
Share

Metabolic Reprogramming by Zika Virus Provokes Inflammation in Human Placenta

Scientists showed, using large scale metabolomics, that ZIKV infection reprogrammed placental lipidome by impairing the lipogenesis pathways. ZIKV-induced metabolic alterations provided building blocks for lipid droplet biogenesis and intracellular membrane rearrangements to support viral replication.
[Nature Communications]
Abstract
Bookmark

No account yet? Register

0
Share

Mesenchymal Stem Cells Offer a Drug-Tolerant and Immune-Privileged Niche to Mycobacterium tuberculosis

Investigators report that mesenchymal stem cells (MSCs) sheltered Mybacterium tuberculosis (Mtb) to help tolerate anti-TB drugs. MSCs readily took up Mtb and allowed unabated mycobacterial growth despite having a functional innate pathway of phagosome maturation.
[Nature Communications]
Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis | Nature Communications. (n.d.). Retrieved June 17, 2020, from https://www.nature.com/articles/s41467-020-16877-3 Cite
Abstract
Bookmark

No account yet? Register

0
Share

TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis

Leishmania-infected Tlr7−/− mice developed a chronic unhealing lesion, despite Th1 cell differentiation, and scientists showed that Tlr7−/− neutrophils alone mediated this effect. Conversely, topical treatment with a TLR7 agonist early in infection induced smaller lesion development than in untreated mice.
[Cell Reports]
Regli, I. B., Passelli, K., Martínez-Salazar, B., Amore, J., Hurrell, B. P., Müller, A. J., & Tacchini-Cottier, F. (2020). TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis. Cell Reports, 31(10). https://doi.org/10.1016/j.celrep.2020.107746 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Shedding of Brucella melitensis Happens through Milk Macrophages in the Murine Model of Infection

Pregnant Balb/cByJ mice were intraperitoneally infected with 105 CFU of the 16 M reference strain, a 16 M mCherry mutant or a human isolate. Milk was collected over the course of lactation, and subjected to culture and immunofluorescence assays.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share
Share