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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Evasion of NKG2D-Mediated Cytotoxic Immunity by Sarbecoviruses
[Cell] Researchers found that SARS-CoV-2 evaded NKG2D recognition by surface downregulation of MIC-A/B via shedding, observed in human lung tissue and COVID-19 patient serum.
Interferon-Induced Transmembrane Protein-1 Competitively Blocks Ephrin Receptor A2-Mediated Epstein–Barr Virus Entry into Epithelial Cells
[Nature Microbiology] Scientists reported that interferon-induced transmembrane protein-1 (IFITM1) inhibited Ephrin receptor A2 (EphA2)-mediated Epstein–Barr virus (EBV) entry into epithelial cells (ECs). RNA-sequencing and clinical sample analysis showed reduced IFITM1 in EBV-positive ECs and a negative correlation between IFITM1 level and EBV copy number.
COVID-19 and Asthma Onset in Children
[Pediatrics] This retrospective cohort study examined children ages 1 to 16 within the Children’s Hospital of Philadelphia Care Network who received PCR testing for SARS-CoV-2 between March 1, 2020 and February 28, 2021.
HIV-1–Infected T Cell Clones Are Shared Across Cerebrospinal Fluid and Blood During ART
[JCI Insight] Researchers profiled people with HIV and uninfected controls through single-cell transcriptomic and T cell receptor sequencing to understand the dynamics of HIV persistence in the central nervous system.
Indirect CD4+ T Cell Protection against Mouse Gamma-Herpesvirus Infection via Interferon Gamma
[Journal Of Virology] Scientists showed that the action of IFNγ was indirect, as CD4+ T cell-mediated control of type 1 alveolar epithelial cells infection depended on IFNγ receptor expression in CD11c+ cells.
SARS-CoV-2 nsp15 Preferentially Degrades AU-Rich dsRNA via Its dsRNA Nickase Activity
[Nucleic Acids Research] The authors prepared numerous RNA substrates, including both long substrates mimicking the viral genome and short defined RNA, to clarify the substrate preference and cleavage pattern of SARS-CoV-2 nsp15.
Canada Likely to Miss WHO’s Hepatitis C Elimination Target, Research Shows
[University of Waterloo] Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.
Inflammation and Cytomegalovirus Viremia during Pregnancy Drive Sex-Differentiated Differences in Mortality and Immune Development in HIV-Exposed Infants
[Nature Communications] In a secondary analysis of the SHINE trial in rural Zimbabwe researchers explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.
Single Cell Analysis Unveils B Cell-Dominated Immune Subtypes in HNSCC for Enhanced Prognostic and Therapeutic Stratification
[International Journal Of Oral Science] Using single-cell RNA sequencing data from the Gene Expression Omnibus database, the study identified distinct gene expression patterns in tumor-infiltrating B cells (TIL-BAs). Head and neck squamous cell carcinoma samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised clustering.
Biofabrication Directions in Recapitulating the Immune System-on-a-Chip
[Advanced Healthcare Materials] The authors cover the state of the art in the intricate landscape of immune organs-on-chip models, shedding light on the pivotal role of biofabrication technologies in bridging the gap between conceptual design and physiological relevance.
SARS-CoV-2 Infection Activates Inflammatory Macrophages in Vascular Immune Organoids
[Scientific Reports] The authors established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection.
Virological, Innate, and Adaptive Immune Profiles Shaped by Variation in Route and Age of Host in Murine Cytomegalovirus Infection
[Applied And Environmental Microbiology] To assess the role of route and age at infection in modeling human cytomegalovirus in mice, scientists infected prepubescent and young sexually mature C57BL/6 mice intranasally, a likely physiological route in humans) and intraperitoneally, which is frequently used experimental route, and is possibly akin to transplant-mediated infection.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
