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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Single Cell Analysis Unveils B Cell-Dominated Immune Subtypes in HNSCC for Enhanced Prognostic and Therapeutic Stratification
[International Journal Of Oral Science] Using single-cell RNA sequencing data from the Gene Expression Omnibus database, the study identified distinct gene expression patterns in tumor-infiltrating B cells (TIL-BAs). Head and neck squamous cell carcinoma samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised clustering.
Biofabrication Directions in Recapitulating the Immune System-on-a-Chip
[Advanced Healthcare Materials] The authors cover the state of the art in the intricate landscape of immune organs-on-chip models, shedding light on the pivotal role of biofabrication technologies in bridging the gap between conceptual design and physiological relevance.
SARS-CoV-2 Infection Activates Inflammatory Macrophages in Vascular Immune Organoids
[Scientific Reports] The authors established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection.
Virological, Innate, and Adaptive Immune Profiles Shaped by Variation in Route and Age of Host in Murine Cytomegalovirus Infection
[Applied And Environmental Microbiology] To assess the role of route and age at infection in modeling human cytomegalovirus in mice, scientists infected prepubescent and young sexually mature C57BL/6 mice intranasally, a likely physiological route in humans) and intraperitoneally, which is frequently used experimental route, and is possibly akin to transplant-mediated infection.
Secreted Phospholipase PLA2G2E Contributes to Regulation of T Cell Immune Response Against Influenza Virus Infection
[Journal Of Virology] Investigators demonstrated that Pla2g2e-/- mice had significantly lower survival rates and higher viral loads in lungs compared to wild-type mice following influenza virus infection.
Lessons in Persistence: New Long COVID Trials AIm To Clear LIngering Virus
[Science Insider] Long COVID has been a vexing foe, but these clinical trials mark a new chapter. They’re the first targeting the syndrome’s underlying biology, including the one Hayden joined, focus on a key question: Is lingering SARS-CoV-2 virus behind patients’ symptoms?
Age-Specific Nasal Epithelial Responses to SARS-CoV-2 Infection
[Nature Microbiology] The authors investigated differences in the cellular landscape and function of pediatric , adult, and older adult ex vivo cultured nasal epithelial cells in response to infection with SARS-CoV-2.
Perinatal Outcomes after Admission with COVID-19 in Pregnancy: A UK National Cohort Study
[Nature Communications] Researchers showed that in this large national cohort comprising two years’ active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women.
Umbilical Cord Blood Culture for Early Onset Sepsis in Preterm Infants
[Pediatric Research] Retrospective analysis at a tertiary care center in Canada of preterm infants less than or equal to 34 0/7 weeks’ gestation with umbilical cord blood culture (UCBC) taken at birth. Of 505 admitted infants, 195 had UCBC.
Myeloid C-Type Lectin Receptors in Innate Immune Recognition
[Immunity] Myeloid C-type lectin receptors exhibited a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns, damage-associated molecular patterns, and markers of altered self.
Long COVID Linked to Signs of Ongoing Inflammatory Responses in Blood
[New Scientist] People with long-COVID after a serious COVID-19 infection have raised levels of many immune molecules in their blood. Better understanding how these molecules can vary could lead to more targeted treatments
AS03 Adjuvant Enhances the Magnitude, Persistence, and Clonal Breadth of Memory B Cell Responses to a Plant-Based COVID-19 Vaccine in Humans
[Science Immunology] Investigators longitudinally analyzed immune responses in healthy adults after two-dose vaccination with either a virus-like particle COVID-19 vaccine (CoVLP), CoVLP adjuvanted with AS03, or a messenger RNA vaccination.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
