Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Applications of Human Organoids in the Personalized Treatment for Digestive Diseases

[Signal Transduction and Targeted Therapy] Over the past few decades, the use of organoids has led to an advanced understanding of the composition of each digestive organ and has facilitated disease modeling, chemotherapy dose prediction, CRISPR-Cas9 genetic intervention, high-throughput drug screening, and identification of SARS-CoV-2 targets, pathogenic infection.

Seagen Announces TUKYSA® (Tucatinib) in Combination with Trastuzumab Granted Priority Review by FDA for Previously Treated HER2-Positive Metastatic Colorectal Cancer

[Seagen, Inc.] Seagen, Inc. announced that the US FDA has accepted for Priority Review the supplemental New Drug Application seeking accelerated approval for TUKYSA® in combination with trastuzumab for adult patients with HER2-positive colorectal cancer.

CAF-Derived Exosomal WEE2-AS1 Facilitates Colorectal Cancer Progression via Promoting Degradation of MOB1A to Inhibit the Hippo Pathway

[Cell Death & Disease] Elevated expression of WEE2-AS1 in cancer-associated fibroblasts-derived small extracellular vesicles increased colorectal cancer cell proliferation in vitro.

Anti-Metastatic Effects of 1,2, 3,4, 6-Penta-O-Galloyl-β-D-Glucose in Colorectal Cancer: Regulation of Cathepsin B-Mediated Extracellular Matrix Dynamics and Epithelial-to-Mesenchymal Transition

[Pharmacological Research] The effects of 1,2,3,4,6-penta-O-galloyl-β-D-glucose on cell proliferation, colony formation ability, motility, migration were investigated in colon cancer cells using BrdU, colony formation, scratch, and transwell assays, respectively.

Intestinal Epithelial C-maf Expression Determines Enterocyte Differentiation and Nutrient Uptake in Mice

[Journal of Experimental Medicine] The authors identified c-Maf as an enterocyte-specific transcription factor within the small intestine epithelium. c-Maf expression was determined by opposing Noggin/BMP signals and overlapped with the zonated enrichment of nutrient transporters in the mid-villus region

Autophagic State Prospectively Identifies Facultative Stem Cells in the Intestinal Epithelium

[EMBO Reports] Researchers utilized in vivo labeling combined with ex vivo organoid formation assays to evaluate how cell age and autophagic state contributed to facultative stem cell activity within secretory lineages.

MPST Deficiency Promotes Intestinal Epithelial Cell Apoptosis and Aggravates Inflammatory Bowel Disease via AKT

[Redox Biology] Scientists explored the role of 3-mercaptopyruvate sulfurtransferase (MPST), a key enzyme that regulates endogenous H2S biosynthesis, in IBD.

Clone Wars: From Molecules to Cell Competition in Intestinal Stem Cell Homeostasis and Disease

[Experimental & Molecular Medicine] Scientists highlight the mechanisms that regulate stem cell homeostasis in the small intestine, focusing on Wnt signaling and its regulation by RNF43 and ZNRF3, key inhibitors of the Wnt pathway.

Inside the New Institute Looking at Early Cancer

[University of Cambridge] The Institute will see as many as 120 scientists from a broad spectrum of disciplines across the University – working together under one roof to understand the fundamental biology of how cancer develops and how it evolves, and applying that knowledge to pioneer new methods.

Colorectal Cancer Organoid Models Uncover Oxaliplatin-Resistant Mechanisms at Single Cell Resolution

[Cellular Oncology] The authors established two strains of patient-derived organoids (PDOs) selected from oxaliplatin-resistant and treatment-naïve CRC patients. To dissect the drug-resistant mechanisms, these colorectal cancer-PDOs were subjected to single-cell RNA sequencing.

From Organoids to Bedside: Advances in Modeling, Decoding and Targeting of Colorectal Cancer

[International Journal of Cancer] Investigators review the role of organoids to decode cancer cell dynamics and tumor microenvironmental complexity with the underlying bi-directional crosstalk.

In-Depth Analysis of the Relationship Between Bovine Intestinal Organoids and Enteroids Based on Morphology and Transcriptome

[Tissue Engineering and Regenerative Medicine] “Natural” organoids were obtained by tissue culture from fetal bovine jejunum and enteroids were successfully isolated and cultured from organoids without supplementing exogenous factors and Matrigel.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.