Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Antibody-Exatecan Conjugates with a Novel Self-Immolative Moiety Overcome Resistance in Colon and Lung Cancer

[Cancer Discovery] The authors designed an antibody-drug conjugates class using a novel self-immolative T moiety for traceless conjugation and release of exatecan, a more potent Topoisomerase I inhibitor with less sensitivity to multidrug resistance.

γδ T Cells Are Effectors of Immunotherapy in Cancers with HLA Class I Defects

[Nature] Researchers applied a combination of transcriptomic and imaging approaches for an in-depth analysis of immune checkpoint blockade (ICB)-naive and ICB-treated DNA mismatch repair-deficient (MMR-d) colon cancers, as well as in vitro functional assays, and found evidence indicating that γδ T cells mediated responses to HLA-class-I-negative MMR-d tumors during treatment with ICB.

In Vivo Development of Immune Tissue in Human Intestinal Organoids Transplanted into Humanized Mice

[Nature Biotechnology] To decipher human intestinal–immune crosstalk during development, scientists generated human intestinal organoids (HIOs) containing immune cells by transplanting HIOs under the kidney capsule of mice with a humanized immune system.

Chlorogenic Acid Improves Intestinal Morphology via Enhancing Intestinal Stem Cell Activity

[Journal Of The Science Of Food And Agriculture] Scientists hypothesized that chlorogenic acid (CGA) exerted intestinal health effects via modulating intestinal stem cell functions. Lgr5-EGFP mice and intestinal organoids derived from the above mice were treated for 14 days and 3 days using CGA solution, respectively.

Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair

[Inflammatory Bowel Diseases] Researchers demonstrated that stem cell factor functioned as a pro-inflammatory mediator in mucosal tissues and that specific neutralization of SCF248 could be a viable therapeutic option to reduce intestinal inflammation and promote mucosal wound repair in individuals with inflammatory bowel disease.

PHB2 Promotes Colorectal Cancer Cell Proliferation and Tumorigenesis through NDUFS1-Mediated Oxidative Phosphorylation

[Cell Death & Disease] Investigators revealed that Prohibitin 2 (PHB2) expression was elevated in precancerous adenomas and colorectal cancer, which promoted cell proliferation and tumorigenesis of colorectal cancer.

Identification and Characterization of a First-Generation Inhibitor of Claudin-1 in Colon Cancer Progression and Metastasis

[Biomedicine & Pharmacotherapy] Scientists found that a novel small molecule, PDS-0330, may prevent colorectal progression and metastasis by interfering with claudin-1 binding to metastatic oncogene Src. This resulted in the inhibition of the resistance to anoikis, invasion, and tumorigenic potential in claudin-1 overexpressed cells.

The Crosstalk between Microbial Sensors ELMO1 and NOD2 Shape Intestinal Immune Responses

[Virulence] The authors studied whether nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and engulfment and cell motility protein-1 (ELMO1) interacted with each other directly or indirectly to regulate bacterial sensing. They used stem-cell-based approaches to recapitulate normal gut physiology, and intestinal bacteria, Adherent invasive E. coli, as a stressor to assess gut function.

Frizzled-7 Modulates Goblet and Paneth Cell Fate and Maintains the Homeostasis in Intestines

[Development] Loss of Frizzled-7, an important element in the Wnt signaling, interrupted the differentiation of intestinal stem cells into absorptive progenitors instead of secretory progenitors, precursors of goblet and Paneth cells.

Effects of the Anti-inflammatory Drug Celecoxib on Cell Death Signaling in Human Colon Cancer

[Naunyn-Schmiedeberg's Archives of Pharmacology] Researchers investigated the correlation between celecoxib-induced endoplasmic reticulum stress and the effects of celecoxib against cell death signaling. Treatment of human colon cancer HCT116 cells with celecoxib reduced their viability and resulted in a loss of mitochondrial membrane potential.

SOTIO Doses First Patient in AURELIO-05 Phase II Trial of Nanrilkefusp Alfa in Combination with Cetuximab

[SOTIO Biotech] SOTIO Biotech announced that the first patient was dosed in its Phase II AURELIO-05 combination trial of nanrilkefusp alfa, an IL-15 superagonist, and cetuximab in patients with colorectal cancer.

Ferroptosis in Colorectal Cancer: A Future Target?

[British Journal Of Cancer] The authors provide an overview of recent research in ferroptosis and its potential role as a therapeutic target in colorectal cancer. They also propose future research directions that could help to enhance our understanding of ferroptosis in colorectal cancer.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.