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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Role and Value of the Tumor Microenvironment in the Progression and Treatment Resistance of Gastric Cancer
[Oncology Reports] Scientists explore the latest progress in understanding the intricate interactions between cancer cells and their immediate environment in gastric cancer, highlighting the implications for disease pathogenesis and therapeutic interventions.
Fort Worth-Based Barricade Therapeutics Secures $14 Million CPRIT Grant to Advance Colorectal Cancer Treatment
[Fort Worth Report] Barricade Therapeutics, Corp. has received a $14,005,035 grant from the Cancer Prevention and Research Institute of Texas (CPRIT). The funding will support the Phase I clinical development of Barricade’s innovative therapeutic candidate BT-1501 for APC mut advanced colorectal cancer patients.
DUSP6 Regulates Notch1 Signaling in Colorectal Cancer
[Nature Communications] The authors showed that DUSP6 could function as a phosphatase for Notch1, thereby regulating Notch1 transmembrane/intracellular region stability and transcriptional activity, thus influencing colorectal cancer development.
Frizzled5 Controls Murine Intestinal Epithelial Cell Plasticity through Organization of Chromatin Accessibility
[Developmental Cell] Investigators elucidated the pivotal role of Frizzled5 (Fzd5), a Wnt pathway receptor, as a determinant of murine intestinal epithelial cell fate.
FZD5 Controls Intestinal Crypt Homeostasis and Colonic Wnt Surrogate Agonist Response
[Developmental Cell] An epithelial-specific Fzd5 knockout (KO) elicited lethal pan-intestinal crypt and villus loss, whereas an Lgr5+ intestinal stem cell (ISC)-specific Fzd5 KO depleted Lgr5+ ISCs via premature differentiation and repressed Wnt target genes.
The miR-1269a/PCDHGA9/CXCR4/β-Catenin Pathway Promotes Colorectal Cancer Invasion and Metastasis
[Cellular & Molecular Biology Letters] Protocadherin gamma subfamily A, 9 (PCDHGA9) expression was detected using quantitative real-time quantitative polymerase chain reaction in 63 pairs of colorectal cancer tissues.
miR-122/NEGR1 Axis Contributes Colorectal Cancer Liver Metastasis by PI3K/AKT Pathway and Macrophage Modulation
[Journal of Translational Medicine] Scientists identified new targets for predicting and treating colorectal cancer (CRC) liver metastasis (CRLM). Bioinformatics analysis highlighted the miR-122/NEGR1 axis as crucial in CRLM. In vitro assays explored the impact of this axis on CRC cell proliferation, invasion, and migration.
Roles of the lncRNAs MEG3, PVT1, and H19 tagSNPs in Gastric Cancer Susceptibility
[BMC Cancer] In Ardabil, a high-risk area in North‒West Iran, 795 blood samples were collected from 396 cases and 399 controls.
Asparagine Prevents Intestinal Stem Cell Aging via the Autophagy-Lysosomal Pathway
[Aging Cell] Researchers utilized an aging Drosophila model screening of amino acids and found that asparagine, a nonessential amino acid in vivo, exhibited its profound anti-aging properties on intestinal stem cells.
The Dichotomous Roles of Microbial-Modified Bile Acids 7-Oxo-DCA and isoDCA in Intestinal Tumorigenesis
[Proceedings of The National Academy of Sciences of The United States of America] Researchers found that although high-fat diet treatment in mice elevated both 7-oxo-deoxycholic acid (7-oxo-DCA) and isoDCA levels, during intestinal tumorigenesis, 7-oxo-DCA levels increased while isoDCA levels decreased.
RNF4 Mediated Degradation of PDHA1 Promotes Colorectal Cancer Metabolism and Metastasis
[npj Precision Oncology] The authors investigated the role of RNF4-mediated ubiquitination and degradation of PDHA1 in CRC metabolism and metastasis. Integrating TCGA and Clinical Proteomic Tumor Analysis Consortium databases, proteomic, clinical, and metabolomic analyses were performed, revealing PDHA1 as a prognostic marker in CRC.
Metabolic Disruption Exacerbates Intestinal Damage during Sleep Deprivation by Abolishing HIF1α-Mediated Repair
[Cell Reports] Scientists found that chronic sleep deprivation led to colonic damage through continuous hypoxia. However, HIF1α was paradoxically dysregulated in the colon.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
