Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Personalis and UCSF to Study Clinical Utility of ctDNA for Treatment Response in Colorectal Cancer

[Personalis, Inc.] Personalis, Inc. announced a collaboration with UC San Francisco (UCSF) that will deploy a personalized liquid biopsy-based research use only assay for a study of patients with colorectal cancer.

Pyxis Oncology Announces FDA Clearance of Two IND Applications

[Pyxis Oncology, Inc.] Pyxis Oncology, Inc. announced that it has received clearance for its two Investigational New Drug (IND) applications from the US FDA to initiate Phase I clinical trials.

Erasca Announces Clinical Trial Collaboration and Supply Agreement with Pierre Fabre to Evaluate Eras-007 and Encorafenib Combination

[Erasca, Inc.] Erasca, Inc. announced a clinical trial collaboration and supply agreement with Pierre Fabre for the BRAF inhibitor encorafenib, BRAFTOVI®, within key international territories.

Inflammation Promotes Resistance to Immune Checkpoint Inhibitors in High Microsatellite Instability Colorectal Cancer

[Nature Communications] The authors presented that in patients with high microsatellite instability colorectal cancer and a local inflammatory condition, the primary tumor progressed but its liver metastasis regressed upon Pembrolizumab treatment.

Small Noncoding Vault RNA2-1 Disrupts Gut Epithelial Barrier Function via Interaction with HuR

[EMBO Reports] Researchers identified vtRNA2-1 as a novel regulator of the intestinal barrier via interaction with RNA-binding protein HuR.

ARD1 Stabilizes NRF2 through Direct Interaction and Promotes Colon Cancer Progression

[Life Sciences] ARD1 was found to possibly potentiate the oncogenic function of NRF2 in human colon cancer by stabilizing the transcription factor.

m6A-Modified circFNDC3B Inhibits Colorectal Cancer Stemness and Metastasis via RNF41-Dependent ASB6 Degradation

[Cell Death & Disease] Scientists demonstrated that YTHDC1 facilitated cytoplasmic export of m6A-modified circFNDC3B, thereby suppressing stem-like and metastatic properties of colorectal cells.

Ciclopirox Drives Growth Arrest and Autophagic Cell Death through STAT3 in Gastric Cancer Cells

[Cell Death & Disease] Researchers unmasked a novel mechanism by which ciclopirox (CPX) regulated growth and autophagic cell death in gastric cancer cells via regulating the phosphorylation of STAT3 both at Tyr705 and Ser727 residues, and suggeseted that CPX may be a potential treatment for gastric cancer.

Differential Involvement of LUBAC-Mediated Linear Ubiquitination in Intestinal Epithelial Cells and Macrophages during Intestinal Inflammation

[Journal of Pathology] Scientists used two experimental mouse models of inflammatory bowel diseases to examine the role of linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation.

Nanoparticle-Mediated PRDX2 Inhibition for Specific Targeting of CHK2-Null Colorectal Cancer

[ACS Biomaterials Science & Engineering] Investigators targeted the synthetic lethal interaction between PRDX2 and CHK2 in colorectal cancer cells using N-Carbamoyl alanine-loaded chitosan nanoparticles to selectively inhibit the CHK2-null HCT116 cells.

Knockdown of Membrane-Bound Complement Regulatory Proteins Suppresses Colon Cancer Growth in Mice through Inducing Tumor Cell Apoptosis

[International Immunopharmacology] Membrane-bound complement regulatory proteins (mCRPs) expression in human colon cancer cells were upregulated by STAT3/STAT6/p38 MAPK signaling and mCRPs knockdown reduced colon cancer growth in mice through inducing tumor cell apoptosis.

Gastric Cancer Stem Cell-Derived Exosomes Promoted Tobacco Smoke-Triggered Development of Gastric Cancer by Inducing the Expression of circ670

[Medical Oncology] Scientists provided a new insight into tobacco smoke promoting the progression of gastric cancer, demonstrating that tobacco smoke-induced exosomes promoted the spheroidizing ability, stemness genes expression, and epithelial-mesenchymal transition process of gastric cancer stem cells.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.