MicroRNA-17-5p Regulates EMT by Targeting Vimentin in Colorectal Cancer

The authors demonstrated that miRNA-17-5p regulated vimentin expression, thereby regulating metastasis of colorectal cancer.
[British Journal of Cancer]
Abstract

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BRAF Mutated Colorectal Cancer: New Treatment Approaches

The authors study the biology of a subgroup of colon cancer harboring a BRAF mutation, to understand the current approach in clinical research.
[Cancers]
AbstractFull ArticleGraphical Abstract

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Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]
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SphK2 Confers 5-Fluorouracil Resistance to Colorectal Cancer via Upregulating H3K56ac-Mediated DPD Expression

Investigators showed that SphK2high conferred 5-fluorouracil resistance through upregulated tumoral dihydropyrimidine dehydrogenase.
[Oncogene]
Abstract

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Devonian Health Group Announces Notice of Allowance for a US Patent Application Covering Use of Thykamine for the Treatment of Ulcerative Colitis

Devonian Health Group, Inc. announced today that the United States Patent and Trademark Office has issued a Notice of Allowance for U.S patent application titled, “Thylakoid Extract Composition and Formulation for the Treatment of Inflammatory Bowel Disease,” covering the use of Thykamine for the treatment of ulcerative colitis.
[Devonian]
Press Release

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DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25

Investigators showed that neutrophil extracellular traps (NETs) were abundant in the liver metastases of patients with breast and colon cancers, and that serum NETs could predict the occurrence of liver metastases in patients with early-stage breast cancer.
[Nature]
Yang, L., Liu, Q., Zhang, X., Liu, X., Zhou, B., Chen, J., … Song, E. (2020). DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature, 1–6. https://doi.org/10.1038/s41586-020-2394-6 Cite
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
Editorial

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The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells from Their Niche and Differentiation into Enterocyte vs Secretory Lineages

Scientists analyzed Notch regulation by examining expression profiles of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.
[Gastroenterology]
Baulies, A., Angelis, N., Foglizzo, V., Danielsen, E. T., Patel, H., Novellasdemunt, L., Kucharska, A., Carvalho, J., Nye, E., Coppi, P. D., & Li, V. S. W. (2020). The Transcription co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation into Enterocyte vs Secretory Lineages. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.06.012 Cite
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FGFR4 Increases EGFR Signaling by Inducing AREG Expression and Attenuates Response to EGFR Inhibitors in Colon Cancer

Researchers investigated a potential crosstalk between FGFR4 and EGFR, and the effect of anti‐EGFR therapy in colon cancer treatment.
[Cancer Science]
Abstract

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Zeb2 Drives Invasive and Microbiota-Dependent Colon Carcinoma

Scientists identified a synergistic inflammatory tumor-promoting mechanism through which resident intestinal microbiota boosts invasive colorectal cancer cell development in an epithelial-to-mesenchymal transition-prone tissue environment.
[nature cancer]
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miR-503-5p Inhibits Colon Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Directly Downregulating VEGF-A

Scientists observed considerable downregulation of miR-503-5p expression in colon cancer cells and tissues and significant correlation with the TNM stage, differentiation grade and lymph node metastasis of colon cancer. Overexpression of miR-503-5p promoted the apoptosis and G1 arrest of colon cancer cells, and inhibited migration, proliferation, invasion and colony formation.
[Gene Therapy]
Abstract

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Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

The authors address the recent advances in in vitro colorectal carcinoma (CRC) model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.
[Cancers]
AbstractFull Article

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