Label-Free Cancer Stem-Like Cell Assay Conducted at a Single Cell Level Using Microfluidic Mechanotyping Devices

Researchers investigated the mechanical phenotype of the human colon adenocarcinoma cell, HT29, which is known to be a heterogeneous cell line with both multipotency and self-renewal abilities.
[Analytical Chemistry]
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Lixte Biotechnology Announces Collaboration with Netherlands Cancer Institute (Amsterdam) and Oncode Institute (Utrecht) to Identify the Most Promising Drug Combinations for its Lead Clinical Compound, LB-100, for Cancer Treatment

Lixte Biotechnology Holdings, Inc. announced entry into a collaboration with the Netherlands Cancer Institute, Amsterdam, and Oncode Institute, Utrecht to identify the most promising drugs to be combined with LB-100, and potentially LB-100 analogues, to be used to treat a range of cancers, as well as to identify the specific molecular mechanisms underlying the identified combinations.
[Lixte Biotechnology Holdings, Inc.]
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Integrated Analysis of Dysregulated microRNA and mRNA Expression in Intestinal Epithelial Cells Following Ethanol Intoxication and Burn Injury

Investigators performed an integrated analysis of miRNA and RNA sequencing data to identify a network of interactions within small intestinal epithelial cells (IECs) which could promote gut barrier disruption.
[Scientific Reports]
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CCL11 Exacerbates Colitis and Inflammation-Associated Colon Tumorigenesis

Scientists showed that CCL11 was involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis and in colon tumorigenesis in the azoxymethane-DSS model of colitis-associated carcinogenesis.
[Oncogene]
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Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies

Researchers investigated if selective blocking of neuropeptide Y (NPY) receptors, NPY1R or NPY2R, using small molecule non-peptide antagonists (BIBP-3222 for NPY1R and BIIE-0246 for NPY2R) in the colon could attenuate intestinal inflammation by lowering TNF levels.
[Inflammatory Bowel Diseases]
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NF-κB-Dependent Induction of Porcine β-Defensin 114 Regulates Intestinal Epithelium Homeostasis

Investigators showed that the porcine β-defensin 114 (PBD114) was an endotoxin-responsive gene expressed in intestinal epithelial cells. Analysis on expression profiling of PBD114 gene using an infected porcine model and IPEC-J2 cells unveiled a pattern of induction in response to stimulation of various toll-like receptors.
[International Journal of Biological Macromolecules]
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Combining Repurposed Drugs to Treat Colorectal Cancer

Scientists provide a set of pharmacological concepts focusing on drug repurposing for treating colorectal cancer and that are relevant for the application of new drug combinations against this disease.
[Drug Discovery Today]
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Precirix Dosed First Patients in Phase I/II Clinical Study

Precirix NV announced that it has dosed the first patients in its Phase I/II clinical study of CAM-H2 for the treatment of HER2-positive metastatic cancer. The trial will evaluate safety, tumor uptake, tumor retention and early signs of antitumor activity of single-agent CAM-H2 in HER2-positive metastatic breast and gastric/gastro-esophageal cancer patients.
[Precirix NV]
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Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids

Investigators explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity.
[Physiological Genomics]
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MYC Hyperactivates WNT Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of DKK3

Researchers examined the role of DKK3 by overexpression and knockdown and discovered that DKK3 suppressed Wnt signaling in APC-null murine colonic organoids and human colon cancer cells despite the presence of downstream activating mutations in the Wnt pathway.
[Molecular Cancer Research]
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Irbesartan, an Angiotensin II Type 1 Receptor Blocker, Inhibits Colitis-Associated Tumorigenesis by Blocking the MCP-1/CCR2 Pathway

Irbesartan suppressedmonocyte chemoattractant protein-1 (MCP-1) production and the accumulation of Ly6C+CCR2+ monocytes and fibrocytes in the inflamed colon, downregulated the expression of type 1 collagen and matrix metalloproteinase 9 and inhibited the development of intestinal fibrosis and tumors.
[Scientific Reports]
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