Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Signatures of Co-deregulated Genes and Their Transcriptional Regulators in Colorectal Cancer

Researchers reanalyzed 19 GEO gene expression profiles to identify and annotate colorectal cancer versus normal signatures, single-gene perturbation, and single-drug perturbation signatures.
[npj Systems Biology and Applications]
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ORTIKOS, the First and Only Once-Daily Dose for Treatment of Mild to Moderate Crohn’s Disease, Now Available in the U.S.

Ferring Pharmaceuticals Inc. announced the launch of ORTIKOS™ in the United States, which was approved as the only once-daily treatment of mild to moderate active Crohn’s disease involving the ileum and/or the ascending colon, in patients 8 years of age and older, and maintenance of clinical remission in adults involving the ileum and/or the ascending colon for up to three months.
[Ferring Pharmaceuticals (Businesswire, Inc.)]
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The HIF Target ATG9A is Essential for Epithelial Barrier Function and Tight Junction Biogenesis

Investigators found that lentiviral-mediated knockdown of ATG9A in intestinal epithelial cells prevented epithelial barrier formation by >95% and resulted in significant mislocalization of multiple tight junction proteins.
[Molecular Biology of the Cell]
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Ciclopirox Activates PERK-Dependent Endoplasmic Reticulum Stress to Drive Cell Death in Colorectal Cancer

Scientists report that ciclopirox exhibited strong antitumorigenic properties in colorectal cancer by inducing cell cycle arrest, repressing cell migration, and invasion by affecting N-cadherin, Snail, E-cadherin, MMP-2, and MMP-9 expression. Disruption of cellular bioenergetics contributed to ciclopirox-associated inhibition of cell growth, migration, and invasion.
[Cell Death & Disease]
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Continuous Formation of Small Clusters with LGR5-Positive Cells Contributes to Tumor Growth in a Colorectal Cancer Xenograft Model

Investigators evaluated the growth of moderate differentiated colorectal cancer from LGR5-positive cells, which was a cancer stem cell marker of colorectal cancer, using xenograft and three-dimensional culture models spatiotemporally.
[Laboratory Investigation]
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Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

The authors demonstrate that the DNA damage-resistant Msi1+ cells are cycling intestinal stem cells that maintain and regenerate the intestinal epithelium.
[Cell Reports]
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Microbiota-Derived Metabolite Promotes HDAC3 Activity in the Gut

Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Remarkably, inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated HDAC3-dependent proliferation, and countered butyrate inhibition of colonic growth.
[Nature]
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Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis

The authors review recent findings on Src family kinase (SFK) signalling during intestinal homeostasis, regeneration and tumorigenesis. They also describe the key nongenetic mechanisms underlying SFK tumour activities in colorectal cancer, and discuss how these mechanisms could be exploited in therapeutic strategies to target SFK signalling in metastatic colon cancer.
[Cancers]
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LINC00941 Promotes CRC Metastasis through Preventing SMAD4 Protein Degradation and Activating the TGF-β/SMAD2/3 Signaling Pathway

LINC00941 was found to activate EMT by directly binding the SMAD4 protein MH2 domain and competing with β-TrCP to prevent SMAD4 protein degradation, thus activating the TGF-β/SMAD2/3 signaling pathway.
[Cell Death & Differentiation]
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European Commission Grants Marketing Authorisation for World’s First Subcutaneous Formulation of Infliximab, Remsima® SC, for an Additional Five Indications including for Use in Inflammatory Bowel Disease and Ankylosing Spondylitis

Celltrion Healthcare announced that the European Commission has granted marketing authorisation for Remsima® subcutaneous formulation for the treatment of adult patients with ankylosing spondylitis, Crohn’s disease, ulcerative colitis, psoriatic arthritis and psoriasis.
[Celltrion Healthcare ]
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Henlius and Accord Healthcare Receive EMA Approval for Zercepac®, Trastuzumab Biosimilar

Shanghai Henlius Biotech, Inc. and Accord Healthcare Limited jointly announced the European Commission has approved Zercepac ® for the treatment of HER2-positive early breast cancer, HER2-positive metastatic breast cancer and HER2-positive metastatic gastric cancer.
[Henlius]
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