Scientists explored the mechanism regarding AMP-activated protein kinase-mediated β-catenin degradation in chemotherapy resistance in colon cancer. β-catenin was upregulated in colon cancer tissues and cells, as it was positively correlated with the malignancy and poor prognosis, and chemotherapy resistance of colon cancer.
[Molecular Therapy-Nucleic Acids]
Yu, Y., Tian, Z., Yang, L., Zhu, D., Ding, X., Jing, X., Liu, H., & Guo, P. (2021). AMP-activated protein kinase-induced β-catenin degradation through Parkin phosphorylation reverses chemotherapy resistance of colon cancer cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.01.006 Cite
0