Processed Foods Drive Intestinal Barrier Permeability and Microvascular Diseases

Investigators showed in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of chronic kidney disease.
[Science Advances]
Snelson, M., Tan, S. M., Clarke, R. E., Pasquale, C. de, Thallas-Bonke, V., Nguyen, T.-V., Penfold, S. A., Harcourt, B. E., Sourris, K. C., Lindblom, R. S., Ziemann, M., Steer, D., El-Osta, A., Davies, M. J., Donnellan, L., Deo, P., Kellow, N. J., Cooper, M. E., Woodruff, T. M., … Coughlan, M. T. (2021). Processed foods drive intestinal barrier permeability and microvascular diseases. Science Advances, 7(14), eabe4841. https://doi.org/10.1126/sciadv.abe4841 Cite
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HomeoboxC6 Promotes Metastasis by Orchestrating the DKK1/Wnt/β-Catenin Axis in Right-Sided Colon Cancer

Hmeobox C6 was validated to be overexpressed in right-sided colon cancer and associated with poor prognosis.
[Cell Death & Disease]
Qi, L., Chen, J., Zhou, B., Xu, K., Wang, K., Fang, Z., Shao, Y., Yuan, Y., Zheng, S., & Hu, W. (2021). HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03630-x Cite
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USP42 Protects ZNRF3/RNF43 from R-Spondin-Dependent Clearance and Inhibits Wnt Signaling

Researchers showed that the USP42 antagonised R‐spondin by protecting ZNRF3/RNF43 from ubiquitin‐dependent clearance.
[EMBO Reports]
Giebel, N., de Jaime-Soguero, A., García del Arco, A., Landry, J. J. M., Tietje, M., Villacorta, L., Benes, V., Fernández-Sáiz, V., & Acebrón, S. P. (2021). USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling. EMBO Reports, n/a(n/a), e51415. https://doi.org/10.15252/embr.202051415 Cite
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Camel Whey Protein Hydrolysates Induced G2/M Cellcycle Arrest in Human Colorectal Carcinoma

Peptides from milk proteins is gaining popularity in various therapeutics including human cancer. Researchers investigated the anti-cancerous and anti-inflammatory properties of camel whey protein hydrolysates
[Scientific Reports]
Murali, C., Mudgil, P., Gan, C.-Y., Tarazi, H., El-Awady, R., Abdalla, Y., Amin, A., & Maqsood, S. (2021). Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma. Scientific Reports, 11(1), 7062. https://doi.org/10.1038/s41598-021-86391-z Cite
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Clemson Researcher Receives Grant to Study the Effects of Arsenic on Intestinal Stem Cells

Clemson University scientist Lisa Bain has received a National Institute of Environmental Health Sciences grant to continue researching the effects of arsenic exposure on intestinal stem cells.
[Clemson University]
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Long Noncoding RNA (lncRNA) EIF3J-DT Induces Chemoresistance of Gastric Cancer via Autophagy Activation

In vitro and in vivo experiments showed that EIF3J-DT activated autophagy and induced drug resistance in gastric cancer cells by targeting ATG14.
[Autophagy]
Luo, Y., Zheng, S., Wu, Q., Wu, J., Zhou, R., Wang, C., Wu, Z., Rong, X., Huang, N., Sun, L., Bin, J., Liao, Y., Shi, M., & Liao, W. (2021). Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation. Autophagy, 0(0), 1–19. https://doi.org/10.1080/15548627.2021.1901204 Cite
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Colon Epithelial Cell TGFβ Signaling Modulates the Expression of Tight Junction Proteins and Barrier Function in Mice

In vitro colon organoid culture was utilized to assess junction-related gene expression by qPCR and trans-epithelial resistance. In silico analyses of human inflammatory bowel disease and colon cancer databases were performed.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Marincola Smith, P., Choksi, Y. A., Markham, N. O., Hanna, D. N., Zi, J., Weaver, C. J., Hamaamen, J. A., Lewis, K. B., Yang, J., Liu, Q., Kaji, I., Means, A. L., & Beauchamp, R. D. (2021). Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00053.2021 Cite
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AP-2alpha Regulates S-Phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer

CRISPR-Cas9 and shRNA were used to eliminate TFAP2A expression in HCT116 and a panel of colon cancer cell lines.
[Molecular Cancer Research]
Beck, A. C., Cho, E., White, J. R., Paemka, L., Li, T., Gu, V. W., Thompson, D. T., Koch, K. E., Franke, C., Gosse, M., Wu, V. T., Landers, S. R., Pamatmat, A. J., Kulak, M. V., & Weigel, R. J. (2021). AP-2alpha Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0867 Cite
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HUTCHMED Initiates a Phase Ib/II Trial of Surufatinib in Combination with Tislelizumab in Patients with Advanced Solid Tumors

Hutchison China MediTech Limited has initiated a Phase Ib/II study of surufatinib in combination with BeiGene’s tislelizumab in patients with advanced solid tumors in the US and Europe.
[Hutchison China MediTech Limited]
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Four Female Researchers and Six Male Researchers Receive Top Award for Early Researchers

Four female and six male researchers are to receive the Heinz Maier-Leibnitz Prize this year, the top award for early career investigators in Germany. The prizes are each worth €20,000 and will be presented at an award ceremony on 4 May that is to be held virtually due to the coronavirus pandemic.
[DFG (EurekAlert!)]
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Porcine Colonoids and Enteroids Keep the Memory of Their Origin during Regeneration

Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.
[American Journal of Physiology-Cell Physiology]
Barnett, A. M., Mullaney, J. A., Hendriks, C., Le Borgne, L., McNabb, W. C., & Roy, N. (2021). Porcine colonoids and enteroids keep the memory of their origin during regeneration. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00420.2020 Cite
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