AMP-Activated Protein Kinase-Induced β-Catenin Degradation through Parkin Phosphorylation Reverses Chemotherapy Resistance of Colon Cancer Cells

Scientists explored the mechanism regarding AMP-activated protein kinase-mediated β-catenin degradation in chemotherapy resistance in colon cancer. β-catenin was upregulated in colon cancer tissues and cells, as it was positively correlated with the malignancy and poor prognosis, and chemotherapy resistance of colon cancer.
[Molecular Therapy-Nucleic Acids]
Yu, Y., Tian, Z., Yang, L., Zhu, D., Ding, X., Jing, X., Liu, H., & Guo, P. (2021). AMP-activated protein kinase-induced β-catenin degradation through Parkin phosphorylation reverses chemotherapy resistance of colon cancer cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.01.006 Cite
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HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor

The authors showed that HAND1 is expressed in aggressive gastrointestinal stromal tumor, modulating KIT and core transcription factor expression and supporting proliferative cellular programs.
[Clinical Cancer Research]
Hemming, M. L., Coy, S., Lin, J.-R., Andersen, J. L., Przybyl, J., Mazzola, E., Ahmed, A. H. A., Rijn, M. van de, Sorger, P. K., Armstrong, S. A., Demetri, G. D., & Santagata, S. (2021). HAND1 and BARX1 act as transcriptional and anatomic determinants of malignancy in gastrointestinal stromal tumor. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3538 Cite
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A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Non-Essential Modes of Oncogenic Transformation

CRISPR/Cas9-mediated ARID1A knockout in primary TP53-/- human gastric organoids induced morphologic dysplasia, tumorigenicity and mucinous differentiation.
[Cancer Discovery]
Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., Mah, A. T., Tercan, B., Sockell, A., Xu, H., Seoane, J. A., Chen, J., Shmulevich, I., Weissman, J. S., Curtis, C., … Kuo, C. J. (2021). A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-1109 Cite
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NTPDase8 Protects Mice from Intestinal Inflammation by Limiting P2Y6 Receptor Activation: Identification of a New Pathway of Inflammation for the Potential Treatment of IBD

Scientists investigated the role of nucleoside triphosphate diphosphohydrolase-8 (NTPDase8) in intestinal inflammation. Human intestinal epithelial cells express NTPDase8 and P2Y6 similarly as in mice.
[Gut]
Salem, M., Lecka, J., Pelletier, J., Marconato, D. G., Dumas, A., Vallières, L., Brochu, G., Robaye, B., Jobin, C., & Sévigny, J. (2021). NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD. Gut. https://doi.org/10.1136/gutjnl-2020-320937 Cite
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Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models

Researchers studied the cytotoxic, proinflammatory, and DNA damaging properties of polyvinylpyrrolidone‐capped silver and titanium dioxide engineered nanomaterials in four in vitro models of increasing complexity—from proliferating Caco‐2 and HT29‐MTX‐E12 monocultures to long‐term transwell triple cultures including THP‐1 macrophages to reproduce the human intestine in healthy versus inflamed‐like state.
[Small]
Kämpfer, A. A. M., Busch, M., Büttner, V., Bredeck, G., Stahlmecke, B., Hellack, B., Masson, I., Sofranko, A., Albrecht, C., & Schins, R. P. F. (n.d.). Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models. Small, n/a(n/a), 2004223. https://doi.org/https://doi.org/10.1002/smll.202004223 Cite
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Proteomics Analysis of Human Intestinal Organoids during Hypoxia and Reoxygenation as a Model to Study Ischemia-Reperfusion Injury

Investigators demonstrated the use of human small intestinal organoids to model ischemia-reperfusion injury by exposing organoids to hypoxia and reoxygenation.
[Cell Death & Disease]
Kip, A. M., Soons, Z., Mohren, R., Duivenvoorden, A. A. M., Röth, A. A. J., Cillero-Pastor, B., Neumann, U. P., Dejong, C. H. C., Heeren, R. M. A., Olde Damink, S. W. M., & Lenaerts, K. (2021). Proteomics analysis of human intestinal organoids during hypoxia and reoxygenation as a model to study ischemia-reperfusion injury. Cell Death & Disease, 12(1), 1–13. https://doi.org/10.1038/s41419-020-03379-9 Cite
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IGFBPs Mediate IGF-1’s Functions in Retinal Lamination and Photoreceptor Development during Pluripotent Stem Cell Differentiation to Retinal Organoids

Researchers investigated the expression of insulin growth factor binding proteins and their role in the generation of human retinal organoids from human pluripotent stem cells.
[Stem Cells]
IGFBPs mediate IGF‐1’s functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids - Zerti - - STEM CELLS - Wiley Online Library. (n.d.). Retrieved January 15, 2021, from https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3331?af=R Cite
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Semiconducting Polymer Nanoparticles for Photothermal Ablation of Colorectal Cancer Organoids

Tumor organoid technology was used to evaluate the ablative potential of CD44-targeted polymer nanoparticles using hyaluronic acid (HA) as the targeting agent and coating it onto hybrid donor acceptor polymer particles (HDAPPs) to form HA-HDAPPs.
[Scientific Reports]
McCarthy, B., Cudykier, A., Singh, R., Levi-Polyachenko, N., & Soker, S. (2021). Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids. Scientific Reports, 11(1), 1532. https://doi.org/10.1038/s41598-021-81122-w Cite
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Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense

Using various models of intestinal cryptosporidiosis, the authors found that Cryptosporidium infection caused suppression of mitogen-activated protein kinase signaling in infected murine intestinal epithelial cells.
[Microorganisms]
He, W., Li, J., Gong, A.-Y., Deng, S., Li, M., Wang, Y., Mathy, N. W., Feng, Y., Xiao, L., & Chen, X.-M. (2021). Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense. Microorganisms, 9(1), 151. https://doi.org/10.3390/microorganisms9010151 Cite
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Plumericin Protects against Experimental Inflammatory Bowel Disease by Restoring Intestinal Barrier Function and Reducing Apoptosis

Plumericin was evaluated for its ability to improve barrier function and to reduce apoptotic parameters during inflammation, both in intestinal epithelial cells, and in an animal experimental model of 2, 4, 6-dinitrobenzene sulfonic acid-induced colitis.
[Biomedicines]
Rapa, S. F., Di Paola, R., Cordaro, M., Siracusa, R., D’Amico, R., Fusco, R., Autore, G., Cuzzocrea, S., Stuppner, H., & Marzocco, S. (2021). Plumericin Protects against Experimental Inflammatory Bowel Disease by Restoring Intestinal Barrier Function and Reducing Apoptosis. Biomedicines, 9(1), 67. https://doi.org/10.3390/biomedicines9010067 Cite
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Leading BioSciences Announces FDA Fast Track Designation Granted to LB1148 for the Treatment of Postoperative Gastrointestinal Dysfunction Associated with Pediatric Cardiovascular Surgery

Leading BioSciences, Inc. announced that the FDA has granted Fast Track Designation to LB1148 for the treatment of postoperative gastrointestinal dysfunction associated with pediatric heart surgery.
[Leading BioSciences, Inc. (GlobeNewswire, Inc.)]
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