Investigators summarize the existing research on polyamine metabolism and function, specifically the role of polyamines in gastric immune cell and epithelial cell function.
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This microscopic colitis review discusses the understanding of the immune response, genetics and the microbiome in disease pathogenesis along with progress in disease management through robust clinical trials.
[Nature Reviews Disease Primers]
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Scientists demonstrated that αSMA+ cancer-associated fibroblast in colorectal cancer (CRC) exert tumor-restraining functions via BMP4/TGFβ1 paracrine signaling that served to suppress Lgr5+ CSCs and promoted anti-tumor immunity, ultimately limiting CRC progression.
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Researchers provided in vivo evidence that RAD51-Associated Protein 1(RAD51AP1) played a critical role in colorectal cancer (CRC) growth and drug resistance by regulating CRC stem cell self-renewal.
[Molecular Cancer Research]
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Scientists proposed that a high-fat diet enhanced intestinal stemness and tumorigenicity by engaging a peroxisome proliferator-activated receptor-fatty acid oxidation (PPAR-FAO) program.
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In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.
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Researchers showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells, suggesting that exosomal miR-21-5p was involved in angiogenesis and vascular permeability in CRC.
[Cell Death & Disease]
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Scientists examined the function of the RNF20/RNF40/H2Bub1 axis in intestinal inflammation in inflammatory bowel disease (IBD) patients and mouse models. They analyzed underlying molecular pathways in isolated primary intestinal epithelial cells and confirmed their findings in IBD resection specimens.
[Cell Death & Differentiation]
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The authors investigated the signaling pathways through which ONC201/CHOP crosstalk was regulated in ONC201-treated nonmetastatic and metastatic colorectal cancer cell lines.
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Using human gastric carcinoma cell lines, researchers showed that H. pylori increased the proliferation, growth, migration, and invasiveness of gastric cancer cells via its effects on semaphorin 5A and that H. pylori increased the expression of MMP9 in gastric cancer cells via the semaphorin 5A-mediated ERK signaling pathway.
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The impact of surface charge on the delivery of 5-ASA loaded PLGA nanoparticles into the lumen of organoids was investigated. Alginate and chitosan were used to coat the nanoparticles and provide negative and positive charges on the particles, respectively.
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