Deregulation of the CD44-NANOG-MDR1 Associated Chemoresistance Pathways of Breast Cancer Stem Cells Potentiates the Anti-cancer Effect of Kaempferol in Synergism with Verapamil

Researchers used Kaempferol in combination with Verapamil, in multiple assays to determine if there was an inhibitory effect on breast cancer stem cells.
[Toxicology and Applied Pharmacology]
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SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth

Downregulation of SET-domain containing 5 (SETD5) significantly decreased breast cancer stem-like cells properties and glycolysis in vitro and in vivo.
[American Journal of Pathology]
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Tumor Radioresistance Caused by Radiation-Induced Changes of Stem-Like Cell Content and Sub-lethal Damage Repair Capability

Four types of human oral squamous carcinoma cell lines, non-radioresistant cell lines, and radioresistant cell lines, were used to measure the surviving fraction after single-dose irradiation, split-dose irradiation, and multi-fractionated irradiation.
[Scientific Reports]
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Estrogen Receptor Beta Increases Clear Cell Renal Cell Carcinoma Stem Cell Phenotype via Altering the circPHACTR4/miR-34b-5p/C-myc Signaling

Scientists found estrogen receptor beta could increase the CSC population via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.
[FASEB Journal]
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FOXM1 Mediates GDF-15 Dependent Stemness and Intrinsic Drug Resistance in Breast Cancer

The expressions and interactions of GDF-15, FOXM1, and stemness (OCT4 and SOX2), and drug resistance (ABCC5) markers were evaluated in breast cancer.
[Molecular Biology Reports]
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Tanshinone IIA Attenuates the Stemness of Breast Cancer Cells via Targeting the miR-125b/STARD13 Axis

In vitro mammary spheroid formation, flow cytometry assay on CD24−/CD44+ sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells.
[Experimental Hematology & Oncology]
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The Association between Bromodomain (BrD) Proteins and Cancer Stemness in Different Solid Tumor Types

Researchers demonstrated that significant upregulation of ATAD2 and SMARCA4, and downregulation of SMARCA2 was consistently associated with enriched cancer stem cell-like phenotype, respectively.
[International Journal of Cancer]
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Immune Translational Control by CPEB4 Regulates Intestinal Inflammation Resolution and Colorectal Cancer Development

Researchers addressed the contribution of posttranscriptional regulation, by the RNA-binding protein CPEB4, to intestinal immune homeostasis and its role in inflammatory bowel diseases and CRC development.
[iScience]
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Wnt/β-Catenin Signaling in Colorectal Cancer: Is Therapeutic Targeting Even Possible?

The authors reviewed the recent progress of this signal transduction pathway in colorectal tumorigenesis.
[Biochimie]
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Intestinal Absorption Mechanism of Rotundic Acid: Involvement of P-GP and OATP2B1

The molecular properties and the effects of principal parameters were analyzed by liquid chromatography-tandem mass spectrometry.
[Journal of Ethnopharmacology]
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Zealand Pharma Completes Enrollment in EASE-SBS 1 Phase III Trial Assessing Glepaglutide in Patients with Short Bowel Syndrome

Zealand Pharma A/S announced completion of patient enrollment in its pivotal Phase III trial of glepaglutide, the company’s long-acting GLP-2 analog, for the potential treatment of short bowel syndrome.
[Zealand Pharma A/S (GlobeNewswire, Inc.)]
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