A novel miRNA, miR-1185-1, suppressed the expression of CD24 by targeting its 3’UTR and could be inhibited by SIRT1 via histone deacetylation. Targeting SIRT1 by RNA interference led to elevated H3K9 acetylation on the promoter region of miR-1185-1, which increased expression of miR-1185-1 and further repressed CD24 translation and colorectal cancer stemness.
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SIRT1-mediated expression of CD24 and epigenetic suppression of novel tumor suppressor miR-1185-1 increases colorectal cancer stemness | Cancer Research. (n.d.). Retrieved October 16, 2020, from https://cancerres.aacrjournals.org/content/early/2020/10/10/0008-5472.CAN-19-3188 Cite
Using novel Paneth cell-specific IL-22Ra1 knockout mice, researchers showed that IL-22 signaling in Paneth cells was required for small intestinal host defense. They showed that Paneth cell maturation, antimicrobial effector function, expression of specific WNTs, and organoid morphogenesis were dependent on cell-intrinsic IL-22Ra1 signaling.
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Gaudino, S. J., Beaupre, M., Lin, X., Joshi, P., Rathi, S., McLaughlin, P. A., Kempen, C., Mehta, N., Eskiocak, O., Yueh, B., Blumberg, R. S., van der Velden, A. W. M., Shroyer, K. R., Bialkowska, A. B., Beyaz, S., & Kumar, P. (2020). IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti- Salmonella immunity. Mucosal Immunology, 1–13. https://doi.org/10.1038/s41385-020-00348-5 Cite
Artificial modulation of BATF3 was conducted to measure the malignant phenotypes of colorectal cancerc cells, while tumor-bearing mice were examined to determine the in vivo effects.
[Cancer Gene Therapy]
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BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis | Cancer Gene Therapy. (n.d.). Retrieved October 15, 2020, from https://www.nature.com/articles/s41417-020-00223-2 Cite
Luciferase reporter assays results showed that miR-93-5p was a direct target of CA3-AS1 in SGC-7901 and BCG-823. BTG3 was identified as a direct target gene of miR-93-5p. Restore experiments showed that CA3-AS1 upregulated the expression level of BTG3 and inhibited the gastric cancer cells invasion by sponging miR-93-5p.
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The solid lipid nanoparticle(SLN)-loaded 5-FU was developed by utilizing a Strategic and unique Method to Advance and Refine the Treatment of colorectal cancer through hot and cold homogenization approach. The SLN was made of unique PEGylated lipids and combination of the surfactants.
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Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
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cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17.
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Researchers investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
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Investigators report that NAD-dependent deacetylase sirtuin-1 (SIRT1) signaling regulated colorectal cancer (CRC) stemness by enhancing expression of CD24, a CRC stemness promoter.
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In vitro and in vivo functional analyses showed that B7-H3 enhanced resistance against irradiation in colorectal cancer cells by upregulating KIF15 expression via NF-κB, which activated ERK1/2 signaling, a key pathway involved in radioresistance in cancers.
[Cell Death & Disease]
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B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer | Cell Death & Disease. (n.d.). Retrieved October 6, 2020, from https://www.nature.com/articles/s41419-020-03041-4 Cite
In this study, two flavonols galangin and kaempferol were heated at 100°C for 30 min prior to assessing their effects on barrier function of rat intestinal epithelial (IEC-6) cells.
[Journal of Nutritional Biochemistry]
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Fan, J., Zhao, X.-H., & Li, T.-J. (2020). Heat treatment of galangin and kaempferol inhibits their benefits to improve barrier function in rat intestinal epithelial cells: Galangin & kaempferol improve IEC-6 cells barrier function. The Journal of Nutritional Biochemistry, 108517. https://doi.org/10.1016/j.jnutbio.2020.108517 Cite