Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells from Their Niche and Differentiation into Enterocyte vs Secretory Lineages

Scientists analyzed Notch regulation by examining expression profiles of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.
[Gastroenterology]
Baulies, A., Angelis, N., Foglizzo, V., Danielsen, E. T., Patel, H., Novellasdemunt, L., Kucharska, A., Carvalho, J., Nye, E., Coppi, P. D., & Li, V. S. W. (2020). The Transcription co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation into Enterocyte vs Secretory Lineages. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.06.012 Cite
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Zeb2 Drives Invasive and Microbiota-Dependent Colon Carcinoma

Scientists identified a synergistic inflammatory tumor-promoting mechanism through which resident intestinal microbiota boosts invasive colorectal cancer cell development in an epithelial-to-mesenchymal transition-prone tissue environment.
[nature cancer]
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FGFR4 Increases EGFR Signaling by Inducing AREG Expression and Attenuates Response to EGFR Inhibitors in Colon Cancer

Researchers investigated a potential crosstalk between FGFR4 and EGFR, and the effect of anti‐EGFR therapy in colon cancer treatment.
[Cancer Science]
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miR-503-5p Inhibits Colon Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Directly Downregulating VEGF-A

Scientists observed considerable downregulation of miR-503-5p expression in colon cancer cells and tissues and significant correlation with the TNM stage, differentiation grade and lymph node metastasis of colon cancer. Overexpression of miR-503-5p promoted the apoptosis and G1 arrest of colon cancer cells, and inhibited migration, proliferation, invasion and colony formation.
[Gene Therapy]
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Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

The authors address the recent advances in in vitro colorectal carcinoma (CRC) model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.
[Cancers]
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Flightless-1 Inhibits ER Stress-Induced Apoptosis in Colorectal Cancer Cells by Regulating Ca2+ Homeostasis

Scientists demonstrated that flightless-1 regulated endoplasmic reticulum stress-induced apoptosis in colon cancer cells by modulating Ca2+ homeostasis.
[Experimental and Molecular Medicine]
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Cilostazol Protects against Acetic Acid-Induced Colitis in Rats: Possible Role for cAMP/SIRT1 Pathway

The authors investigated the role of cAMP/silent information regulator-1 pathway in the protective effect of cilostazol using rat model of acetic acid-induced colitis.
[European Journal of Pharmacology]
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Evodiamine Has Therapeutic Efficacy in Ulcerative Colitis by Increasing Lactobacillus acidophilus Levels and Acetate Production

Investigators found that evodiamine mitigation of dextran sulfate sodium-induced colitis was associated with increased in L. acidophilus and protective acetate production, which might be a promising strategy for treating ulcerative colitis.
[Pharmacological Research]
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First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer

Researchers characterized the clinicopathological link between CHD1L and colorectal cancer (CRC), determined the mechanism(s) by which CHD1L drove malignant CRC, and discovered the first inhibitors with potential for novel treatments for CRC.
[Molecular Cancer therapeutics]
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Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Researchers studied the role of bile acids and G protein-coupled bile acid receptor 1 (TGR5) in intestinal renewal, and regulation of intestinal stem cell function in mice and intestinal organoids.
[Gastroenterology]
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