Glucagon like Peptide-2 for Intestinal Stem Cell and Paneth Cell Repair during Graft-Versus-Host Disease in Mice and Humans

Investigators found that L-cells were a target of acute graft-versus-host disease (GVHD) and that glucagon-like-peptide-2-based treatment of acute GVHD restored intestinal homeostasis via an increase of intestinal stem cells and paneth cells without impairing graft-versus-leukemia effects.
[Blood]
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Lineage Reversion Drives WNT Independence in Intestinal Cancer

Scientists showed that while WNT suppression blocked tumor growth in most organoid and in vivo colorectal cancer (CRC) models, the accumulation of CRC-associated genetic alterations enabled drug resistance and WNT-independent growth.
[Cancer Discovery]
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Latexin Deficiency in Mice Up-Regulates Inflammation and Aggravates Colitis through hECTD1/Rps3/Nf-κB Pathway

Ectopic expression of Latexin led to IκBα accumulation in intestinal epithelial cells, however, latexin knockdown enhanced the interaction of HECTD1 and Rps3, contributing to the ubiquitination degradation of IκBα, and subsequently enhanced inflammatory response.
[Scientific Reports]
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MicroRNA-17-5p Regulates EMT by Targeting Vimentin in Colorectal Cancer

The authors demonstrated that miRNA-17-5p regulated vimentin expression, thereby regulating metastasis of colorectal cancer.
[British Journal of Cancer]
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BRAF Mutated Colorectal Cancer: New Treatment Approaches

The authors study the biology of a subgroup of colon cancer harboring a BRAF mutation, to understand the current approach in clinical research.
[Cancers]
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Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]
Devarasetty, M., Dominijanni, A., Herberg, S., Shelkey, E., Skardal, A., & Soker, S. (2020). Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo. Scientific Reports, 10(1), 9832. https://doi.org/10.1038/s41598-020-66785-1 Cite
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SphK2 Confers 5-Fluorouracil Resistance to Colorectal Cancer via Upregulating H3K56ac-Mediated DPD Expression

Investigators showed that SphK2high conferred 5-fluorouracil resistance through upregulated tumoral dihydropyrimidine dehydrogenase.
[Oncogene]
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Devonian Health Group Announces Notice of Allowance for a US Patent Application Covering Use of Thykamine for the Treatment of Ulcerative Colitis

Devonian Health Group, Inc. announced today that the United States Patent and Trademark Office has issued a Notice of Allowance for U.S patent application titled, “Thylakoid Extract Composition and Formulation for the Treatment of Inflammatory Bowel Disease,” covering the use of Thykamine for the treatment of ulcerative colitis.
[Devonian]
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DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25

Investigators showed that neutrophil extracellular traps (NETs) were abundant in the liver metastases of patients with breast and colon cancers, and that serum NETs could predict the occurrence of liver metastases in patients with early-stage breast cancer.
[Nature]
Yang, L., Liu, Q., Zhang, X., Liu, X., Zhou, B., Chen, J., … Song, E. (2020). DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature, 1–6. https://doi.org/10.1038/s41586-020-2394-6 Cite
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells from Their Niche and Differentiation into Enterocyte vs Secretory Lineages

Scientists analyzed Notch regulation by examining expression profiles of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.
[Gastroenterology]
Baulies, A., Angelis, N., Foglizzo, V., Danielsen, E. T., Patel, H., Novellasdemunt, L., Kucharska, A., Carvalho, J., Nye, E., Coppi, P. D., & Li, V. S. W. (2020). The Transcription co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation into Enterocyte vs Secretory Lineages. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.06.012 Cite
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