The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer

The authors found that cells depleted of Ajuba were less proliferative, more sensitive to irradiation, migrated less and less efficient in colony formation. In addition, loss of Ajuba expression decreased the tumor burden in a murine model of colorectal metastasis to the liver.
[Cancers]
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LintonPharm Announces Authorization From China Health Authority to Proceed With a Global Phase III Trial Evaluating Catumaxomab in Advanced Gastric Cancer

LintonPharm Co. Ltd. announced that China National Medical Products Administration (NMPA) authorized the company to proceed with a Phase III trial for catumaxomab in patients with peritoneal carcinomatosis, a form of advanced gastric cancer that has spread to the tissue that lines the abdominal cavity.
[LintonPharm]
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
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Foreign Researchers Accused of Hiding Links to Chinese Military

Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist]
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Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider]
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Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News]
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‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider]
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Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints

Amid concerns that the torrent of research papers on COVID-19 could be leading to an excess of sloppy work, a computer scientist who develops automated programs to spot duplicate images in research papers is running his software across the world’s coronavirus preprints. So far, his efforts have yielded mixed success and some controversy.
[Nature News]
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Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

Neuregulin 1 robustly stimulated proliferation in crypts and induced budding in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase and AKT.
[Cell Stem Cell]
Jardé, T., Chan, W. H., Rossello, F. J., Kaur Kahlon, T., Theocharous, M., Kurian Arackal, T., Flores, T., Giraud, M., Richards, E., Chan, E., Kerr, G., Engel, R. M., Prasko, M., Donoghue, J. F., Abe, S., Phesse, T. J., Nefzger, C. M., McMurrick, P. J., Powell, D. R., … Abud, H. E. (2020). Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium. Cell Stem Cell. https://doi.org/10.1016/j.stem.2020.06.021 Cite
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EU Leaders Slash Science Spending in €1.8 Trillion Deal

Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[Science Insider]
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