Researchers investigated a potential crosstalk between FGFR4 and EGFR, and the effect of anti‐EGFR therapy in colon cancer treatment.
[Cancer Science]
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Category Archives: Intestinal Cell
Intestinal Cell NewsIntestinal Cell News is an online publication and email newsletter that curates the latest research using intestinal cells.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
FGFR4 Increases EGFR Signaling by Inducing AREG Expression and Attenuates Response to EGFR Inhibitors in Colon Cancer
miR-503-5p Inhibits Colon Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Directly Downregulating VEGF-A
Scientists observed considerable downregulation of miR-503-5p expression in colon cancer cells and tissues and significant correlation with the TNM stage, differentiation grade and lymph node metastasis of colon cancer. Overexpression of miR-503-5p promoted the apoptosis and G1 arrest of colon cancer cells, and inhibited migration, proliferation, invasion and colony formation.
[Gene Therapy]
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Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma
The authors address the recent advances in in vitro colorectal carcinoma (CRC) model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.
[Cancers]
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Flightless-1 Inhibits ER Stress-Induced Apoptosis in Colorectal Cancer Cells by Regulating Ca2+ Homeostasis
Scientists demonstrated that flightless-1 regulated endoplasmic reticulum stress-induced apoptosis in colon cancer cells by modulating Ca2+ homeostasis.
[Experimental and Molecular Medicine]
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Cilostazol Protects against Acetic Acid-Induced Colitis in Rats: Possible Role for cAMP/SIRT1 Pathway
The authors investigated the role of cAMP/silent information regulator-1 pathway in the protective effect of cilostazol using rat model of acetic acid-induced colitis.
[European Journal of Pharmacology]
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Evodiamine Has Therapeutic Efficacy in Ulcerative Colitis by Increasing Lactobacillus acidophilus Levels and Acetate Production
Investigators found that evodiamine mitigation of dextran sulfate sodium-induced colitis was associated with increased in L. acidophilus and protective acetate production, which might be a promising strategy for treating ulcerative colitis.
[Pharmacological Research]
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First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer
Researchers characterized the clinicopathological link between CHD1L and colorectal cancer (CRC), determined the mechanism(s) by which CHD1L drove malignant CRC, and discovered the first inhibitors with potential for novel treatments for CRC.
[Molecular Cancer therapeutics]
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Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration
Researchers studied the role of bile acids and G protein-coupled bile acid receptor 1 (TGR5) in intestinal renewal, and regulation of intestinal stem cell function in mice and intestinal organoids.
[Gastroenterology]
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ROS-Mediated Apoptotic Cell Death of Human Colon Cancer LoVo Cells by Milk δ-Valerobetaine
Dual Role of Ca2+-Activated Cl− Channel Transmembrane Member 16A in Lipopolysaccharide-Induced Intestinal Epithelial Barrier Dysfunction In Vitro.
The authors investigated the effects of transmembrane member 16A on intestinal epithelial barrier function in vitro.
[Cell Death & Disease]
0
GLIS2 Promotes Colorectal Cancer through Repressing Enhancer Activation
Scientists revealed that GLIS family zinc finger 2 selectively regulated the transcription of PUMA but not p21.
[Oncogenesis]
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