Exosomes Released by Breast Cancer Cells under Mild Hyperthermic Stress Possess Immunogenic Potential and Modulate Polarization In Vitro in Macrophages

Cytotoxicity of different hyperthermic temperatures and treatment durations were tested in normal murine macrophages and breast cancer cell lines.
[International Journal of Hyperthermia]
Sen, K., Sheppe, A. E. F., Singh, I., Hui, W. W., Edelmann, M. J., & Rinaldi, C. (2020). Exosomes released by breast cancer cells under mild hyperthermic stress possess immunogenic potential and modulate polarization in vitro in macrophages. International Journal of Hyperthermia, 37(1), 696–710. https://doi.org/10.1080/02656736.2020.1778800 Cite
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Chronic Circadian Disruption Modulates Breast Cancer Stemness and Immune Microenvironment to Drive Metastasis in Mice

Investigators observed that circadian disruption significantly increased cancer-cell dissemination and lung metastasis. It also enhanced the stemness and tumor-initiating potential of tumor cells and created an immunosuppressive shift in the tumor microenvironment.
[Nature Communications]
Hadadi, E., Taylor, W., Li, X.-M., Aslan, Y., Villote, M., Rivière, J., Duvallet, G., Auriau, C., Dulong, S., Raymond-Letron, I., Provot, S., Bennaceur-Griscelli, A., & Acloque, H. (2020). Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice. Nature Communications, 11(1), 3193. https://doi.org/10.1038/s41467-020-16890-6 Cite
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling

Caudatin inhibited breast cancer cell proliferation, mammosphere formation and tumor growth. Caudatin decreased the CD44+/CD24 and aldehyde dehydrogenase positive cell proportions and the levels of c-Myc, Oct4, Sox2, and CD44.
[Biomolecules]
Zhen, X., Choi, H. S., Kim, J.-H., Kim, S.-L., Liu, R., Ko, Y.-C., Yun, B.-S., & Lee, D.-S. (2020). Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling. Biomolecules, 10(6), 925. https://doi.org/10.3390/biom10060925 Cite
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Molecular Characterization of Circulating Tumor Cells Identifies Predictive Markers for Outcome in Primary, Triple‐Negative Breast Cancer Patients

mRNA profiles of circulating tumor cells were analysed in patients with triple‐negative breast cancer before and after therapy to identify additional treatment options.
[Journal of Cellular and Molecular Medicine]
Bittner, A.-K., Keup, C., Hoffmann, O., Hauch, S., Kimmig, R., & Kasimir‐Bauer, S. (n.d.). Molecular characterization of circulating tumour cells identifies predictive markers for outcome in primary, triple-negative breast cancer patients. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15349 Cite
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KLF4 Defines the Efficacy of the Epidermal Growth Factor Receptor Inhibitor, Erlotinib, in Triple-Negative Breast Cancer Cells by Repressing the EGFR gene

Investigators report that krüppel-like factor 4 was a major determinant of epidermal growth factor receptor expression and activity in TNBC cells.
[Breast Cancer Research]
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CRISPR/Cas9 Knockout of Human Arylamine N-Acetyltransferase 1 in MDA-MB-231 Breast Cancer Cells Suggests a Role in Cellular Metabolism

Scientists provided evidence that N-acetyltransferase 1 was not just a xenobiotic metabolizing enzyme and might have a role in endogenous cellular metabolism.
[Scientific Reports]
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Contrasting DCIS and Invasive Breast Cancer by Subtype Suggests Basal-Like DCIS as Distinct Lesions

Investigators performed subtype stratified analyses and identified key differences between ductal carcinoma in situ and invasive breast cancer that suggested subtype specific progression.
[npj Breast Cancer]
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Organoid Models for Mammary Gland Dynamics and Breast Cancer

The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast.
[Current Opinion in Cell Biology]
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