Prolactin Receptor-Driven Combined Luminal and Epithelial Differentiation in Breast Cancer Restricts Plasticity, Stemness, Tumorigenesis and Metastasis

The authors found that interfering with expression of the receptor for the lactogenic hormone prolactin in breast cancer cells representative of the luminal and epithelial breast cancer subtypes resulted in loss of their differentiation state, enriched for stem-like cell subpopulations, and increased their tumorigenic capacity in a subtype-specific manner.
[Oncogenesis]
Shams, A., Binothman, N., Boudreault, J., Wang, N., Shams, F., Hamam, D., Tian, J., Moamer, A., Dai, M., Lebrun, J.-J., & Ali, S. (2021). Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis. Oncogenesis, 10(1), 1–16. https://doi.org/10.1038/s41389-020-00297-5 Cite
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S100A8/A9 Mediate the Reprograming of Normal Mammary Epithelial Cells Induced by Dynamic Cell–Cell Interactions With Adjacent Breast Cancer Cells

To understand the potential effects of cancer cells on surrounding normal mammary epithelial cells, researchers performed direct co-culture of non-tumorigenic mammary epithelial MCF10A cells and various breast cancer cells.
[Scientific Reports]
Jo, S. H., Heo, W. H., Son, H.-Y., Quan, M., Hong, B. S., Kim, J. H., Lee, H.-B., Han, W., Park, Y., Lee, D.-S., Kwon, N. H., Park, M. C., Chae, J., Kim, J.-I., Noh, D.-Y., & Moon, H.-G. (2021). S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell–cell interactions with adjacent breast cancer cells. Scientific Reports, 11(1), 1337. https://doi.org/10.1038/s41598-020-80625-2 Cite
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LncRNA TINCR Favors Tumorigenesis via STAT3–TINCR–EGFR-Feedback Loop by Recruiting DNMT1 and Acting as a Competing Endogenous RNA in Human Breast Cancer

The oncogenic role of TINCR was examined in vitro and in vivo in breast cancer. The interaction between TINCR, DNMT1, and miR-503-5p methylation was explored.
[Cell Death & Disease]
Wang, Q., Liu, J., You, Z., Yin, Y., Liu, L., Kang, Y., Li, S., Ning, S., Li, H., Gong, Y., Xu, S., & Pang, D. (2021). LncRNA TINCR favors tumorigenesis via STAT3–TINCR–EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03188-0 Cite
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Effect of SSRI Exposure on the Proliferation Rate and Glucose Uptake in Breast and Ovary Cancer Cell Lines

The authors examined whether three commonly prescribed selective serotonin reuptake inhibitors (SSRIs), fluoxetine, sertraline and citalopram, affected proliferation or glucose uptake of human breast and ovarian cancer cell lines characterized by different malignancies and metastatic potential.
[Scientific Reports]
Stapel, B., Melzer, C., von der Ohe, J., Hillemanns, P., Bleich, S., Kahl, K. G., & Hass, R. (2021). Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines. Scientific Reports, 11(1), 1250. https://doi.org/10.1038/s41598-020-80850-9 Cite
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Novel Iodine Nanoparticles Target Vascular Mimicry in Intracerebral Triple Negative Human MDA-MB-231 Breast Tumors

MDA-MB-231-cells, iodine nanoparticles, and CD31 were examined by fluorescence confocal microscopy.
[Scientific Reports]
Ridwan, S. M., Hainfeld, J. F., Ross, V., Stanishevskiy, Y., & Smilowitz, H. M. (2021). Novel Iodine nanoparticles target vascular mimicry in intracerebral triple negative human MDA-MB-231 breast tumors. Scientific Reports, 11(1), 1203. https://doi.org/10.1038/s41598-020-80862-5 Cite
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HiberCell and Biodesix Initiate Broad Collaboration for Companion Diagnostic Discovery, Development and Commercialization

HiberCell announced an agreement with Biodesix, Inc. to further the development of an enzyme-linked immunosorbent assay as a companion diagnostic in future registrational trials in breast cancer for Imprime PGG programs.
[HiberCell]
Press Release
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Lidocaine Suppresses Viability and Migration of Human Breast Cancer Cells: TRPM7 as a Target for Some Breast Cancer Cell Lines

Researchers showed that lidocaine affected the viability and migration of breast cancer cells by regulating TRPM7.
[Cancers]
Liu, H., Dilger, J. P., & Lin, J. (2021). Lidocaine Suppresses Viability and Migration of Human Breast Cancer Cells: TRPM7 as a Target for Some Breast Cancer Cell Lines. Cancers, 13(2), 234. https://doi.org/10.3390/cancers13020234 Cite
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Understanding the Role of Integrins in Breast Cancer Invasion, Metastasis, Angiogenesis, and Drug Resistance

Scientists examine the current knowledge of integrins’ role in breast cancer.
[Oncogene]
Yousefi, H., Vatanmakanian, M., Mahdiannasser, M., Mashouri, L., Alahari, N. V., Monjezi, M. R., Ilbeigi, S., & Alahari, S. K. (2021). Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance. Oncogene, 1–21. https://doi.org/10.1038/s41388-020-01588-2 Cite
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Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer

The authors summarize and focus on the recent discoveries of promising macromolecules and cell-based biomarkers for the diagnosis and prognosis of breast cancer and provide implications for therapeutic strategies.
[International Journal of Molecular Sciences]
Wu, H.-J., & Chu, P.-Y. (2021). Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer. International Journal of Molecular Sciences, 22(2), 636. https://doi.org/10.3390/ijms22020636 Cite
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Hsa_circ_0005273 Facilitates Breast Cancer Tumorigenesis by Regulating YAP1-Hippo Signaling Pathway

The effect of knocking down hsa_circ_0005273 in breast cancer cell lines were evaluated by examinations of cell proliferation, migration and cell cycle.
[Journal of Experimental & Clinical Cancer Research]
Wang, X., Ji, C., Hu, J., Deng, X., Zheng, W., Yu, Y., Hua, K., Zhou, X., & Fang, L. (2021). Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway. Journal of Experimental & Clinical Cancer Research, 40(1), 29. https://doi.org/10.1186/s13046-021-01830-z Cite
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The Chick Chorioallantoic Membrane Model: A New In Vivo Tool to Evaluate Breast Cancer Stem Cell Activity

The authors established a CAM-LDA assay able to rapidly reproduce tumor specificities- in particular, the ability of the small population of cancer stem cells to form tumors.
[International Journal of Molecular Sciences]
Pinto, M. T., Ribeiro, A. S., Conde, I., Carvalho, R., & Paredes, J. (2021). The Chick Chorioallantoic Membrane Model: A New In Vivo Tool to Evaluate Breast Cancer Stem Cell Activity. International Journal of Molecular Sciences, 22(1), 334. https://doi.org/10.3390/ijms22010334 Cite
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