First Patient Dosed in Phase II Study of TLX250-CDx in Triple-Negative Breast Cancer

Telix Pharmaceuticals Limited announced that a first patient has been dosed in a Phase II study of TLX250-CDx in patients with TNBC.
[Telix Pharmaceuticals]
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Key Factor Regulating Inflammatory Microenvironment, Metastasis, and Resistance in Breast Cancer: Interleukin-1 Signaling

Scientists provide an overview of interleukin-1 (IL-1)-mediated signal communication in breast cancer and discusses the potential of IL-1 as a therapeutic target especially for metastatic breast cancer and combination therapy and current problems.
[Mediators of Inflammation]
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Breast Cancer Research Focused on Proteins in Natural Killer Cells

UWindsor’s Munir Rahim has been awarded a $120,000 research grant through the Cancer Research Society for launching ground-breaking research that could lead to new treatments for breast cancer.
[University of Windsor]
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Targeting Neurons in the Tumor Microenvironment with Bupivacaine Nanoparticles Reduces Breast Cancer Progression and Metastases

The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk.
[Science Advances]
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Single-Cell RNA Sequencing Reveals Cell Heterogeneity and Transcriptome Profile of Breast Cancer Lymph Node Metastasis

Scientists identified nine cancer cell subclusters including CD44+/ALDH2+/ALDH6A1+ breast cancer stem cells, which had a copy-number variants profile similar to that of normal breast tissue.
[Oncogenesis]
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HIF-1 Recruits NANOG as a Coactivator for TERT Gene Transcription in Hypoxic Breast Cancer Stem Cells

Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.
[Cell Reports]
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Inflammatory Conversion of Quiescent Osteoblasts by Metastatic Breast Cancer Cells through pERK1/2 Aggravates Cancer-Induced Bone Destruction

Scientists observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer metastases.
[Bone Research]
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Melatonin and Doxorubicin Synergistically Enhance Apoptosis via Autophagy-Dependent Reduction of AMPKα1 Transcription in Human Breast Cancer Cells

Scientists found that melatonin synergized with doxorubicin to induce apoptosis of breast cancer cells by decreasing the expression of AMP-activated protein kinase α1 (AMPK α1), which acted as a critical survival factor for cancer cells.
[Experimental & Molecular Medicine]
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ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.
[Cancer Research]
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Tinzaparin Inhibits VL30 Retrotransposition Induced by Oxidative Stress and/or VEGF in HC11 Mouse Progenitor Mammary Cells: Association between Inhibition of Cancer Stem Cell Proliferation and Mammosphere Disaggregation

The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/cancer stem cell (CSC) generation and tumorigenesis.
[Oncology Reports]
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Regulation of a Progenitor Gene Program by SOX4 Is Essential for Mammary Tumor Proliferation

Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.
[Oncogene]
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