Target Identification for Small-Molecule Discovery in the FOXO3a Tumor-Suppressor Pathway Using a Biodiverse Peptide Library

Scientists used a library of peptides from diverse prokaryal genomes to screen macromolecular interactions promoting the nuclear relocalization of Forkhead Box O3 (FOXO3a), a tumor suppressor more frequently inactivated by post-translational modification than mutation, and assessed the impact of these transcriptional changes on the growth of breast cancer cell lines.
[Cell Chemical Biology]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Antibody-Drug Conjugates with Dual Payloads for Combating Breast Tumor Heterogeneity and Drug Resistance

Scientists created homogeneous antibody-drug conjugates containing two distinct payloads that showed HER2-specific cell killing potency, desirable pharmacokinetic profiles, minimal inflammatory response, and marginal toxicity at therapeutic doses.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

0
Share

Tumor Microenvironmental Cytokines Bound to Cancer Exosomes Determine Uptake by Cytokine Receptor-Expressing Cells and Biodistribution

Researchers showed that microenvironmental cytokines, particularly CCL2, decorated cancer exosomes via binding to surface glycosaminoglycan side chains of proteoglycans, causing exosome accumulation in specific cell subsets and organs.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

0
Share

Long Noncoding RNAs in Triple-Negative Breast Cancer: A New Frontier in the Regulation of Tumorigenesis

The authors highlight the association of several long noncoding RNAs in TNBC progression and treatment, along with their possible functions and mechanisms.
[Journal of Cellular Physiology]
Abstract
Bookmark

No account yet? Register

0
Share

Mammary Gland 3D Cell Culture Systems in Farm Animals

Investigators discuss 3D cell culture systems as mammosphere organoids and their relevance for agronomic research.
[Veterinary Research]
Full Article
Bookmark

No account yet? Register

0
Share

Byondis Announces Positive Topline Results of Pivotal Phase III TULIP® Study in Patients With HER2-Positive Unresectable Locally Advanced or Metastatic Breast Cancer

Byondis B.V. announced positive results from the Phase III TULIP® study. The trial compared the efficacy and safety of the company’s antibody-drug conjugate [vic-]trastuzumab duocarmazine to physician’s choice treatment in patients with pretreated HER2-positive unresectable locally advanced or metastatic breast cancer.
[Byondis B.V.]
Press Release
Bookmark

No account yet? Register

0
Share

Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis

Researchers explored whether the microbiome of the gut and mammary gland mediates the dietary effects on breast cancer. In vitro models of the normal breast epithelium showed that lipopolysaccharide disrupted tight junctions and compromised epithelial permeability.
[Cancer Research]
AbstractPress Release
Bookmark

No account yet? Register

0
Share

Oxytocin Receptor Induces Mammary Tumorigenesis through Prolactin/P-STAT5 Pathway

Oxytocin receptor overexpression led to an activation of prolactin/p-STAT5 pathway and created a microenvironment that promoted mammary-specific tumorigenesis.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

Reduced Hyaluronan Cross-Linking Induces Breast Cancer Malignancy in a Caf-Dependent Manner

Compared to normal mammary gland tissues, cross-linked hyaluronan levels were significantly decreased in breast cancer and associated with tumor malignancy.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

Structural Insight into BRCA1-BARD1 Complex Recruitment to Damaged Chromatin

Investigators illustrated how BARD1 simultaneously recognized the DNA damage-induced mark H2AK15ub and DNA replication-associated mark H4K20me0 on the nucleosome.
[Molecular Cell]
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Targeting the Tetraspanin CD81 Reduces Cancer Invasion and Metastasis

Scientists showed that a unique anti-human CD81 antibody (5A6) effectively halted invasion of TNBC cell lines. They demonstrated that 5A6 induced CD81 clustering at the cell membrane and implicated JAM-A protein in the ability of this antibody to inhibit tumor cell invasion and migration.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract
Bookmark

No account yet? Register

0
Share
Share