Differential Reprogramming of Breast Cancer Subtypes in 3D Cultures and Implications for Sensitivity to Targeted Therapy

Researchers systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 breast cancer cell lines cultured in both 2D and 3D conditions.
[Scientific Reports]
Koedoot, E., Wolters, L., Smid, M., Stoilov, P., Burger, G. A., Herpers, B., Yan, K., Price, L. S., Martens, J. W. M., Le Dévédec, S. E., & van de Water, B. (2021). Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy. Scientific Reports, 11(1), 7259. https://doi.org/10.1038/s41598-021-86664-7 Cite
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Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

Researchers showed that β3 integrin induction by the bone microenvironment promotes resistance to chemotherapy through an altered metabolic response that can be defused by combination with αvβ3-targeted mTORC1 inhibitor nanotherapy.
[Molecular Cancer Therapeutics]
Fox, G. C., Su, X., Davis, J. L., Xu, Y., Kwakwa, K. A., Ross, M. H., Fontana, F., Xiang, J., Esser, A. K., Cordell, E., Pagliai, K., Dang, H. X., Sivapackiam, J., Stewart, S. A., Maher, C. A., Bakewell, S. J., Sharma, V., Achilefu, S., Veis, D. J., … Weilbaecher, K. N. (2021). Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-20-0931 Cite
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MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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RANK Signaling Increases after Anti-HER2 Therapy Contributing to the Emergence of Resistance in HER2-Positive Breast Cancer

Scientists showed that RANK bound to HER2 in breast cancer cells and that enhanced RANK pathway activation altered HER2 phosphorylation status.
[Breast Cancer Research]
Sanz-Moreno, A., Palomeras, S., Pedersen, K., Morancho, B., Pascual, T., Galván, P., Benítez, S., Gomez-Miragaya, J., Ciscar, M., Jimenez, M., Pernas, S., Petit, A., Soler-Monsó, M. T., Viñas, G., Alsaleem, M., Rakha, E. A., Green, A. R., Santamaria, P. G., Mulder, C., … Gonzalez-Suarez, E. (2021). RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Breast Cancer Research, 23(1), 42. https://doi.org/10.1186/s13058-021-01390-2 Cite
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3D Bioprinting of Engineered Breast Cancer Constructs for Personalized and Targeted Cancer Therapy

The authors emphasized on the prospective future applications of 3D bioprinted cancer models for rapid and accurate drug screening in breast cancer.
[Journal of Controlled Release]
Sharifi, M., Bai, Q., Babadaei, M. M. N., Chowdhury, F., Hassan, M., Taghizadeh, A., Derakhshankhah, H., Khan, S., Hasan, A., & Falahati, M. (2021). 3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy. Journal of Controlled Release, 333, 91–106. https://doi.org/10.1016/j.jconrel.2021.03.026 Cite
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Anti-Estrogenic and Anti-Aromatase Activities of Citrus Peels Major Compounds in Breast Cancer

The authors investigated the antitumor potential of the most potent compounds in citrus peels on breast cancer by exploring their anti-estrogenic and anti-aromatase activities.
[Scientific Reports]
El-Kersh, D. M., Ezzat, S. M., Salama, M. M., Mahrous, E. A., Attia, Y. M., Ahmed, M. S., & Elmazar, M. M. (2021). Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Scientific Reports, 11(1), 7121. https://doi.org/10.1038/s41598-021-86599-z Cite
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Polyploid Giant Cancer Cells, Stemness and Epithelial-Mesenchymal Plasticity Elicited by Human Cytomegalovirus

Human cytomegalovirus presence paralleled the succession of the observed cellular and molecular events potentially ensuing the transformation process.
[Oncogene]
Nehme, Z., Pasquereau, S., Haidar Ahmad, S., Coaquette, A., Molimard, C., Monnien, F., Algros, M.-P., Adotevi, O., Diab Assaf, M., Feugeas, J.-P., & Herbein, G. (2021). Polyploid giant cancer cells, stemness and epithelial-mesenchymal plasticity elicited by human cytomegalovirus. Oncogene, 1–17. https://doi.org/10.1038/s41388-021-01715-7 Cite
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Review of Studies of Severe Acute Respiratory Syndrome Related Coronavirus–2 Pathogenesis in Human Organoid Models

Scientists highlight key findings from studies that have utilised different human organoid types to investigate the expression of SARS‐CoV‐2 receptors, permissiveness, immune response, dysregulation of cellular functions, and potential antiviral therapeutics.
[Reviews in Medical Virology]
Review of studies of severe acute respiratory syndrome related coronavirus–2 pathogenesis in human organoid models - Egilmezer - - Reviews in Medical Virology - Wiley Online Library. (n.d.). Retrieved March 26, 2021, from https://onlinelibrary.wiley.com/doi/10.1002/rmv.2227 Cite
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The Oncogene AAMDC Links PI3K-AKT-mTOR Signaling with Metabolic Reprograming in Estrogen Receptor-Positive Breast Cancer

Scientists uncovered that Adipogenesis associated Mth938 domain containing (AAMDC) regulates the expression of several metabolic enzymes involved in the one-carbon folate and methionine cycles, and lipid metabolism.
[Nature Communications]
Golden, E., Rashwan, R., Woodward, E. A., Sgro, A., Wang, E., Sorolla, A., Waryah, C., Tie, W. J., Cuyàs, E., Ratajska, M., Kardaś, I., Kozlowski, P., Johnstone, E. K. M., See, H. B., Duffy, C., Parry, J., Lagerborg, K. A., Czapiewski, P., Menendez, J. A., … Blancafort, P. (2021). The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. Nature Communications, 12(1), 1920. https://doi.org/10.1038/s41467-021-22101-7 Cite
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Co-Dependency for MET and FGFR1 in Basal Triple-Negative Breast Cancers

Investigators utilized an established Met-dependent transgenic mouse model of TNBC, human cell lines and patient-derived xenografts to investigate the role of MET in TNBC tumorigenesis.
[npj Breast Cancer]
Sung, V. Y. C., Knight, J. F., Johnson, R. M., Stern, Y. E., Saleh, S. M., Savage, P., Monast, A., Zuo, D., Duhamel, S., & Park, M. (2021). Co-dependency for MET and FGFR1 in basal triple-negative breast cancers. Npj Breast Cancer, 7(1), 1–15. https://doi.org/10.1038/s41523-021-00238-4 Cite
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The Human Intermediate Prolactin Receptor Is a Mammary Proto-Oncogene

An analogous truncated mouse prolactin receptor (mPRLr) was found to be oncogenic when co-expressed with wild-type mPRLr. The authors determined if a similar transforming event occurs with the hPRLr in human breast epithelial cells.
[npj Breast Cancer]
Grible, J. M., Zot, P., Olex, A. L., Hedrick, S. E., Harrell, J. C., Woock, A. E., Idowu, M. O., & Clevenger, C. V. (2021). The human intermediate prolactin receptor is a mammary proto-oncogene. Npj Breast Cancer, 7(1), 1–11. https://doi.org/10.1038/s41523-021-00243-7 Cite
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