Scientists used a library of peptides from diverse prokaryal genomes to screen macromolecular interactions promoting the nuclear relocalization of Forkhead Box O3 (FOXO3a), a tumor suppressor more frequently inactivated by post-translational modification than mutation, and assessed the impact of these transcriptional changes on the growth of breast cancer cell lines.
[Cell Chemical Biology]
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Scientists created homogeneous antibody-drug conjugates containing two distinct payloads that showed HER2-specific cell killing potency, desirable pharmacokinetic profiles, minimal inflammatory response, and marginal toxicity at therapeutic doses.
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Researchers showed that microenvironmental cytokines, particularly CCL2, decorated cancer exosomes via binding to surface glycosaminoglycan side chains of proteoglycans, causing exosome accumulation in specific cell subsets and organs.
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The authors highlight the association of several long noncoding RNAs in TNBC progression and treatment, along with their possible functions and mechanisms.
[Journal of Cellular Physiology]
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Investigators discuss 3D cell culture systems as mammosphere organoids and their relevance for agronomic research.
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Byondis B.V. announced positive results from the Phase III TULIP® study. The trial compared the efficacy and safety of the company’s antibody-drug conjugate [vic-]trastuzumab duocarmazine to physician’s choice treatment in patients with pretreated HER2-positive unresectable locally advanced or metastatic breast cancer.
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Researchers explored whether the microbiome of the gut and mammary gland mediates the dietary effects on breast cancer. In vitro models of the normal breast epithelium showed that lipopolysaccharide disrupted tight junctions and compromised epithelial permeability.
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Oxytocin receptor overexpression led to an activation of prolactin/p-STAT5 pathway and created a microenvironment that promoted mammary-specific tumorigenesis.
[Cell Death & Disease]
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Compared to normal mammary gland tissues, cross-linked hyaluronan levels were significantly decreased in breast cancer and associated with tumor malignancy.
[Cell Death & Disease]
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Investigators illustrated how BARD1 simultaneously recognized the DNA damage-induced mark H2AK15ub and DNA replication-associated mark H4K20me0 on the nucleosome.
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Scientists showed that a unique anti-human CD81 antibody (5A6) effectively halted invasion of TNBC cell lines. They demonstrated that 5A6 induced CD81 clustering at the cell membrane and implicated JAM-A protein in the ability of this antibody to inhibit tumor cell invasion and migration.
[Proceedings of the National Academy of Sciences of the United States of America]
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