The effect of SLC38A2 knockdown in glutamine -sensitive cell lines was analysed.
[British Journal of Cancer]
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Morotti, M., Zois, C. E., El-Ansari, R., Craze, M. L., Rakha, E. A., Fan, S.-J., Valli, A., Haider, S., Goberdhan, D. C. I., Green, A. R., & Harris, A. L. (2020). Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01113-y Cite
Scientists used inducible genetic depletion and two distinct pharmacological inhibitors to investigate the therapeutic potential of targeting SH2 containing protein tyrosine phosphatase-2 (SHP2) in metastatic breast cancer.
Researchers isolated macrophages from mice and humans, polarized them ex vivo, and examined their functional interaction with breast cancer cells in culture and in mice.
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Gómez, V., Eykyn, T. R., Mustapha, R., Flores-Borja, F., Male, V., Barber, P. R., Patsialou, A., Green, R., Panagaki, F., Li, C. W., Fruhwirth, G. O., Ros, S., Brindle, K. M., & Ng, T. (2020). Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells. Science Signaling, 13(652). https://doi.org/10.1126/scisignal.aax4585 Cite
AXL-expressing cells in human mammary epithelial ducts co-expressed markers associated with multipotency, and AXL inhibition abolished colony-formation and self-maintenance activities while promoting terminal differentiation in vitro.
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Engelsen, A. S. T., Wnuk-Lipinska, K., Bougnaud, S., Vatter, F. A. P., Tiron, C., Villadsen, R., Miyano, M., Lotsberg, M. L., Madeleine, N., Panahandeh, P., Dhakal, S., Tan, T. Z., Peters, S. D., Grøndal, S., Aziz, S. M., Nord, S., Herfindal, L., Stampfer, M. R., Sørlie, T., … Lorens, J. B. (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101649 Cite
Microgravity (µg) research might be an unusual method to combat the disease, but cancer biologists decided to harness the power of µg as an exceptional method to increase efficacy and precision of future breast cancer therapies.
[International Journal of Molecular Sciences]
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Nassef, M. Z., Melnik, D., Kopp, S., Sahana, J., Infanger, M., Lützenberg, R., Relja, B., Wehland, M., Grimm, D., & Krüger, M. (2020). Breast Cancer Cells in Microgravity: New Aspects for Cancer Research. International Journal of Molecular Sciences, 21(19), 7345. https://doi.org/10.3390/ijms21197345 Cite
The authors presents the phenotype characteristics of EO771 and its sensitivity to nutrients and different therapies such as radiotherapy, chemotherapy, hormone therapy, and immunotherapy.
Agilent Technologies Inc announced the expansion of Visiopharm’s validated image analysis algorithm to incorporate HercepTest™ mAb pharmDx for Dako Omnis, both CE-IVD marked and recently released for sale in Europe.
[Agilent Technologies Inc]
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The expression of lysine demethylase 2A in cancer-associated fibroblasts was studied using immunohistochemical staining and its association with clinicopathological features and patient’s survival was tested.
[British Journal of Cancer]
The loss of SNAI2 in cancer-associated fibroblasts limited the production of some cytokines, which influenced AKT/ERK tumor signaling and subsequent proliferative and metastatic capacity of ERBB2+ breast cancer cells.
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Blanco-Gómez, A., Hontecillas-Prieto, L., Corchado-Cobos, R., García-Sancha, N., Salvador, N., Castellanos-Martín, A., Sáez-Freire, M. del M., Mendiburu-Eliçabe, M., Alonso-López, D., Rivas, J. D. L., Lorente, M., García-Casas, A., Carmen, S. D., Abad-Hernández, M. del M., Cruz-Hernández, J. J., Rodríguez-Sánchez, C. A., Claros-Ampuero, J., García-Cenador, B., García-Criado, J., … Castillo-Lluva, S. (2020). Stromal SNAI2 is required for ERBB2 breast cancer progression. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0278 Cite
Scientists employed laser microdissection and whole-transcriptome profiling of the breast epithelium prior to and post tumor diagnosis to identify the earliest alterations in breast carcinogenesis.
[npj Breast Cancer]
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Investigators showed that, in addition to PI3K, WAVE3 tyrosine phosphorylation could also be achieved downstream of TGF-β and EGF and that WAVE3 tyrosine phosphorylation was required for its oncogenic activity.
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