Investigators showed that Gal-GalNAc levels increased as human breast cancer progressed, and that occurrence of F. nucleatum gDNA in breast cancer samples correlated with high Gal-GalNAc levels.
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Scientists showed that Protein kinase C theta regulated the sensitivity of TNBC cells to apoptosis triggered by standard-of-care chemotherapy by regulating levels of pro-apoptotic Bim.
[Breast Cancer Research]
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On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
Using chemoproteomic platforms, investigators showed that members of the manumycin family of polyketides, which bore multiple potentially reactive sites, targetted C374 of the putative E3 ligase UBR7 in breast cancer cells, and engaged in molecular glue interactions with the neosubstrate tumor-suppressor TP53, leading to p53 transcriptional activation and cell death.
[Nature Chemical Biology]
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Researchers demonstrated that exposure to mechanical strain promoted invasive and pro-tumorigenic phenotypes in breast cancer cells, indicating that mechanical strain could impact the growth and proliferation of cancer cell, alter exosome production by breast cancer, and induce immunosuppression in the tumor microenvironment by dampening anti-tumor immunity.
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Genentech announced that the Phase III IMpassion031 study, evaluating Tecentriq® in combination with chemotherapy in comparison to placebo plus chemotherapy, met its primary endpoint by demonstrating a statistically significant and clinically meaningful improvement in pathological complete response for the treatment of people with early triple-negative breast cancer, regardless of PD-L1 expression.
The authors revealed that YES1 amplification conferred resistance to HER2-targeted drugs.
[British Journal of Cancer]
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Investigators unveiled that LINC00942 exerted its functions as an oncogene in promoting METTL14-mediated m6A methylation and regulating the expression and stability of its target genes CXCR4 and CYP1B1 in breast cancer initiation and progression.
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The authors focus on the molecular mechanism and function of glutathione peroxidases in the occurrence and development of breast cancer.
[Journal of Translational Medicine]
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Researchers found that GREM1 knockdown inhibited the proliferation of breast cancer cells and xenograft mammary tumour growth, while its overexpression enhanced their viability, growth and invasiveness. Oestrogen-related receptor α, an orphan nuclear hormone receptor, directly interacted with the GREM1 promoter and increased the expression of GREM1.
[British Journal of Cancer]
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Investigators described mammary organoids with a basal‐in phenotype where the basement membrane was located on the interior surface of the organoid.
[Advanced Healthcare Materials]
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