Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Optimizing Mesenchymal Stem Cell Therapy: From Isolation to GMP-Compliant Expansion for Clinical Application
[BMC Molecular and Cell Biology] Researchers demonstrated that infrapatellar fat pad MSCs exhibited enhanced proliferation rates when cultured in MSC-Brew GMP Medium compared to standard MSC media.
Cell Therapy with Placenta-Derived Mesenchymal Stem Cells for Secondary Progressive Multiple Sclerosis Patients in a Phase I Clinical Trial
[Scientific Reports] Investigators evaluated the safety and feasibility of placenta-derived MSCs in five participants with secondary-progressive multiple sclerosis.
Immunomodulatory Multifunctional Janus Collagen-Based Membrane for Advanced Bone Regeneration
[Nature Communications] Researchers presented a Janus collagen-based barrier membrane with immunomodulation. The membrane enhances rat bone marrow-derived MSC infiltration, proliferation, and osteogenic differentiation by regulating the immune microenvironment.
Biosplice Announces First Patient Dosed in Phase II Trial of Cirtuvivint for Advanced Soft-Tissue Sarcomas
[Biosplice (GlobeNewswire)] Biosplice Therapeutics, Inc. (“Biosplice”) announced that the first patient has been dosed in a Phase II clinical trial evaluating cirtuvivint in patients with advanced soft-tissue sarcomas.
Single-Cell Transcriptome Unveils Mesenchymal Cell Diversity in Endometriosis
[Human Molecular Genetics] Through the utilization of scRNA-seq, researchers have unveiled six distinct mesenchymal subclusters in normal and endometriosis-afflicted ovaries, elucidating the diverse functions of mesenchymal populations in endometriosis.
DNA Demethylating Agents Suppress Preclinical Models of Synovial Sarcoma
[Journal of Clinical Investigation] Given that synovial sarcoma is characterized by a peculiarly low DNA hypomethylation profile, researchers hypothesized that further disturbance of DNA methylation would have a negative impact on synovial sarcoma growth.
Bone Mesenchymal Stem Cells Based on Matric Hydrogels Attenuate Intervertebral Disc Degeneration by Suppressing Oxidative Stress-Induced Ferroptosis
[Scientific Reports] Researchers investigated the effect of bone MSCs in intervertebral disc degeneration (IVDD) by magnetic resonance imaging and hematoxylin and eosin staining analysis using a rat-punctured IVDD model.
The Effect of Blue and Green Light on Human Umbilical Cord Mesenchymal Stem Cells for Promoting Proliferation and Wound Healing
[Scientific Reports] Scientists identified the optimal wavelength and irradiation fluence for promoting the proliferation of human umbilical cord MSCs by comparing the effects of different wavelengths and irradiation fluences.
Fusion of Glioma-Associated Mesenchymal Stem/Stromal Cells with Glioma Cells Promotes Macrophage Recruitment and M2 Polarization via M6a Modification of CSF1
[Cell Death & Disease] Investigators showed that glioma-associated MSCs are able to spontaneously fuse with glioma cells both in vitro and in vivo.
The Epigenetic Landscape of Mesenchymal Stem Cell and Extracellular Vesicle Therapy
[Trends In Cell Biology] The authors review epigenetic regulation of MSC and extracellular vesicle therapies, together with current challenges, aiming to deepen the understanding of donor–recipient communication and inspire next-generation approaches to counteract tissue defects and diseases.
Novel PEI-Aldehyde Conjugates for Gene Delivery: Promoting Chondrogenic Differentiation in Human Mesenchymal Stem Cells
[Molecular Therapy - Nucleic Acids] Researchers explored the development of novel polyethyleneimine (PEI)-based polymers functionalized with both cationic guanidinium and hydrophobic aldehyde groups for efficient transfection to human MSCs.
Combinatorial Extracellular Matrix Tissue Chips for Optimizing Mesenchymal Stromal Cell Microenvironment and Manufacturing
[NPJ Regenerative Medicine] Researchers developed tissue chips to study the effects of multi-factorial extracellular matrix (ECM) environments under manufacturable stiffness ranges and multi-component ECM compositions.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
