Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells in Treatment of Cesarean Section Skin Scars: A Randomized Clinical Trial

Ninety primiparous singleton pregnant women undergoing elective cesarean section were randomly allocated to receive placebo, low-dose, or high-dose transdermal hydrogel umbilical cord-MSCs on the surface of the skin incision.
[Stem Cell Research & Therapy]
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Effects of Photobiomodulation Combined with MSCs Transplantation on the Repair of Spinal Cord Injury in Rat

Investigators evaluated the therapeutic effect of human umbilical cord MSCs and laser alone or combined on spinal cord injury.
[Journal of Cellular Physiology]
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MiR-200b in Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviates Inflammatory Injury of Intestinal Epithelial Cells by Targeting High Mobility Group Box 3

Scientists identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. The reduced level of HMGB3 then decreases the inflammatory injury.
[Cell Death & Disease]
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NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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A Circular RNA Map for Human Induced Pluripotent Stem Cells of Fetal Origin

Reprogramming was achieved by a footprint-free strategy. Self-renewal and pluripotency of cord blood MSC-human induced pluripoent stem cells (hiPSC) were investigated in vitro and in vivo, compared to parental MSC, to embryonic stem cells and to F-hiPSC.
[Ebiomedicine]
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A Scaffold Laden with Mesenchymal Stem Cell-Derived Exosomes for Promoting Endometrium Regeneration and Fertility Restoration through Macrophage Immunomodulation

A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
[Acta Biomaterialia]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Dose and Duration of Interferon γ Pre-Licensing Interact with Donor Characteristics to Influence the Expression and Function of Indoleamine-2,3-Dioxygenase in Mesenchymal Stromal Cells

Scientists found that across three human MSC donors, MSCs increased their expression of indoleamine-2,3-dioxygenase in response to both increased dose of IFNγ and duration of pre-licensing.
[Journal of the Royal Society interface]
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Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39−CD73 Signaling Pathway

Gingiva derived-mesenchymal stem cells limited the development of autoantibodies as well as proteinuria, decreases the frequency of plasma cells and lupus nephritis histopathological scores by directly suppressing B cells activation, proliferation and differentiation.
[Journal of Autoimmunity]
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