Three-Dimensional-Printed Polycaprolactone/Polypyrrole Conducting Scaffolds for Differentiation of Human Olfactory Ecto-Mesenchymal Stem Cells into Schwann Cell-Like Phenotypes and Promotion of Neurite Outgrowth

The effect of 3D printed polycaprolactone/polypyrrole conductive scaffolds on differentiation of human olfactory ecto-MSCs into functional Schwann cell-like phenotypes was investigated.
[Journal of Biomedical Materials Research Part A]
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CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma

Scientists generated models of sarcomas bearing kinase fusions and assessed their response to molecularly targeted therapy. Immortalized, untransformed human MSCs, a putative cell-of-origin of sarcomas, were modified using CRISPR-Cas9 to harbor a RET chromosomal translocation.
[Cancer Research]
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Mesenchymal Stromal Cells Encapsulated in Licensing Hydrogels Exert Delocalized Systemic Protection against Ulcerative Colitis via Subcutaneous Xenotransplantation

Researchers demonstrated the capacity of licensing hydrogel-encapsulated human MSCs to limit the in vivo progression of inflammatory bowel diseases.
[European Journal of Pharmaceutics and Biopharmaceutics]
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Disruption of Hematopoiesis Attenuates the Osteogenic Differentiation Capacity of Bone Marrow Stromal Cells

The authors investigated the effect of hematopoietic cells on MSCs using various methods, including flow cytometry, adipogenic and osteogenic differentiation analysis, quantitative PCR, western bloting, and microCT analysis.
[Stem Cell Research & Therapy]
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Breast Cancer Circulating Tumor Cells with Mesenchymal Features — an Unreachable Target?

The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.
[Cellular and Molecular Life Sciences]
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The Application of Mesenchymal Stromal Cells (MSCs) and Their Derivative Exosome in Skin Wound Healing: A Comprehensive Review

Scientists overview recent in vivo reports rendering the therapeutic benefits of the MSCs-based therapies to ease skin wound healing, and so improving quality of life among patients suffering from such conditions.
[Stem Cell Research & Therapy]
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Stem Cell-Derived and Circulating Exosomal microRNAs as New Potential Tools for Diabetic Nephropathy Management

In recent years, a growing line of research has shown the participation of exosomal microRNAs in the pathophysiological processes of diabetic nephropathy (DN), which may provide effective therapeutic and biomarker tools for DN treatment.
[Stem Cell Research & Therapy]
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Lyell Immunopharma Announces FDA Clearance of IND for LYL132, a T-cell Receptor Therapy for Solid Tumors Being Developed in Collaboration with GSK

Lyell Immunopharma, Inc. announced that the US FDA has cleared an Investigational New Drug (IND) application to initiate a Phase I clinical trial for LYL132, an investigational T-cell receptor therapy for patients with solid tumors expressing New York esophageal squamous cell carcinoma 1 that the company is developing in collaboration with GSK.
[Lyell Immunopharma, Inc.]
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miR-223 in Exosomes from Bone Marrow Mesenchymal Stem Cells Ameliorates Rheumatoid Arthritis via Downregulation of NLRP3 Expression in Macrophages

Scientists investigated the therapeutic effect of miR-223 in exosomes secreted by bone marrow MSCs on immune response in the progression of rheumatoid arthritis.
[Molecular Immunology]
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miR-204–Containing Exosomes Ameliorate GVHD-Associated Dry Eye Disease

Investigators reported that exosomes from MSCs administered as eye drops notably alleviated graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery in mice and humans.
[Science Advances]
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Irisin Promotes Cardiac Homing of Intravenously Delivered MSCs and Protects against Ischemic Heart Injury

The authors found that irisin pretreatment increased the cardiac homing of adipose tissue-derived MSCs administered by single and multiple intravenous injections to mice with myocardial ischemia-reperfusion (MI/R) by more than fivefold, which subsequently increased their antiapoptotic, proangiogenic, and antifibrotic effects in rats and mice that underwent MI/R.
[Advanced Science]
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