Bio-Instructive Hydrogel Expands the Paracrine Potency of Mesenchymal Stem Cells

Scientists introduced a customizable collagen I-hyaluronic acid (COL-HA)-based hydrogel platform for the encapsulation of MSCs. Cells encapsulated within COL-HA showed a significant expansion of their secretory profile compared to MSCs cultured in standard (2D) cell culture dishes or encapsulated in other hydrogels.
[Biofabrication]
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Macropinocytosis Requires Gal-3 in a Subset of Patient-Derived Glioblastoma Stem Cells

Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis.
[Communications Biology]
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Apoptotic Mesenchymal Stromal Cells Support Osteoclastogenesis While Inhibiting Multinucleated Giant Cells Formation In Vitro

Scientists focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a calcium-phosphate biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes.
[Scientific Reports]
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Mesenchymal Growth Hormone Receptor Deficiency Leads to Failure of Alveolar Progenitor Cell Function and Severe Pulmonary Fibrosis

The authors identified growth hormone receptor is mainly expressed in mesenchymal cells, and its expression is substantially decreased in idiopathic pulmonary fibrosis lungs.
[Science Advances]
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Emerging Understanding of Apoptosis in Mediating Mesenchymal Stem Cell Therapy

Investigators summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.
[Cell Death & Disease]
Fu, Y., Sui, B., Xiang, L., Yan, X., Wu, D., Shi, S., & Hu, X. (2021). Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy. Cell Death & Disease, 12(6), 1–12. https://doi.org/10.1038/s41419-021-03883-6 Cite
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Human Umbilical Cord Mesenchymal Stem Cell Transfusion in Immune Non-Responders with AIDS: A Multicenter Randomized Controlled Trial

The authors examined the safety and efficacy of human umbilical cord mesenchymal stem cell infusion for immune non-responder patients with chronic HIV-1 infection, who represented an unmet medical need even in the era of efficient antiretroviral therapy.
[Signal Transduction and Targeted Therapy]
Wang, L., Zhang, Z., Xu, R., Wang, X., Shu, Z., Chen, X., Wang, S., Liu, J., Li, Y., Wang, L., Zhang, M., Yang, W., Wang, Y., Huang, H., Tu, B., Liang, Z., Li, L., Li, J., Hou, Y., … Wang, F.-S. (2021). Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS: a multicenter randomized controlled trial. Signal Transduction and Targeted Therapy, 6(1), 1–8. https://doi.org/10.1038/s41392-021-00607-2 Cite
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Calidi Biotherapeutics Announces Partnership with GenScript ProBio for Distribution of its SuperNova-1 Technology

Calidi Biotherapeutics, Inc. announced its partnership with GenScript ProBio for assistance in the advertisement and distribution of Calidi’s proprietary technology platform: SuperNova-1 (SNV-1). The SNV-1 platform is composed of allogeneic, adipose-derived-MSC loaded with an oncolytic agent such as the vaccinia virus.
[Calidi Biotherapeutics, Inc. (Business Wire, Inc.)]
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Systematic Review: Advances of Fat Tissue Engineering as Bioactive Scaffold, Bioactive Material, and Source for Adipose-Derived Mesenchymal Stem Cells in Wound and Scar Treatment

Investigators describe the advances in fat tissue engineering applied to regenerative surgery, through the use of adipose-derived-MSCs, stromal vascular fraction contained in lipofilling/fat graft in wound healing and scar treatment.
[Stem Cell Research & Therapy]
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Endogenous Repair and Regeneration of Injured Articular Cartilage: A Challenging but Promising Therapeutic Strategy

The authors focus on the reasons why articular cartilage (AC) cannot regenerate itself in spite of potential self-repair capacity and summarize the latest developments of the three key components in the field of endogenous AC regeneration.
[Aging and Disease]
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Tissue Mechanics in Stem Cell Fate, Development, and Cancer

The authors review how dysregulation of tissue-level force increases risk of malignancy, promotes tumor progression, and can induce a stem-like phenotype in tumor cells to drive tumor aggression and treatment resistance.
[Developmental Cell]
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Novartis Announces Tabrecta® First Published Overall Survival and Updated Overall Response Data in Patients with METex14 Metastatic NSCLC

Novartis AG has announced the first published mature overall survival and updated overall response rate data following treatment with Tabrecta® in adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to MET exon 14 skipping (METex14).
[Novartis AG]
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