Category Archives: Mesenchymal Cell

Mesenchymal Cell News is an online publication and email newsletter that delivers updates on the latest research in the mesenchymal stem cell field.
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Mesenchymal Cell News is a weekly email newsletter covering topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.

Healthy versus Inflamed Lung Environments Differentially Effect MSCs

Researchers comparatively assessed how the inflammatory environment present in acute respiratory distress syndrome (ARDS) lungs versus the lung environment present in healthy volunteers alters MSC behaviors.
[European Respiratory Journal]
Enes, S. R., Hampton, T. H., Barua, J., McKenna, D. H., Santos, C. C. dos, Amiel, E., Ashare, A., Liu, K. D., Krasnodembskaya, A. D., English, K., Stanton, B. A., Rocco, P. R. M., Matthay, M. A., & Weiss, D. J. (2021). Healthy versus inflamed lung environments differentially effect MSCs. European Respiratory Journal. https://doi.org/10.1183/13993003.04149-2020 Cite
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IL-1β Mediated Nanoscale Surface Clustering of Integrin α5β1 Regulates the Adhesion of Mesenchymal Stem Cells

Scientists found that IL-1β enhanced adhesion of human MSCs via increased focal adhesion contacts in an α5β1 integrin-specific manner.
[Scientific Reports]
Maynard, S. A., Pchelintseva, E., Zwi-Dantsis, L., Nagelkerke, A., Gopal, S., Korchev, Y. E., Shevchuk, A., & Stevens, M. M. (2021). IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells. Scientific Reports, 11(1), 6890. https://doi.org/10.1038/s41598-021-86315-x Cite
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Dual Effects of Hypoxia on Proliferation and Osteogenic Differentiation of Mouse Clonal Mesenchymal Stem Cells

Mouse clonal MSCs were cultured on a Cytodex 3 microcarrier in a spinner flask for a suspension culture under hypoxia condition to increase mass productivity.
[Bioprocess and Biosystems Engineering]
Kim, H., & Kwon, S. (2021). Dual effects of hypoxia on proliferation and osteogenic differentiation of mouse clonal mesenchymal stem cells. Bioprocess and Biosystems Engineering. https://doi.org/10.1007/s00449-021-02563-1 Cite
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Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease

Five groups of pigs were studied after 16 weeks of renovascular disease (RVD), RVD treated four weeks earlier with either percutaneous transluminal renal angioplasty or MSC-derived extracellular vesicles, and normal controls.
[Cells]
Ferguson, C. M., Farahani, R. A., Zhu, X.-Y., Tang, H., Jordan, K. L., Saadiq, I. M., Lerman, A., Lerman, L. O., & Eirin, A. (2021). Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease. Cells, 10(4), 763. https://doi.org/10.3390/cells10040763 Cite
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Athersys Reports That Healios Has Completed Enrollment in the ONE-BRIDGE Study of MultiStem® for Acute Respiratory Distress Syndrome in Japan

Athersys, Inc. announced that its partner HEALIOS K.K. has completed enrollment in the ONE-BRIDGE study in Japan evaluating MultiStem® in patients with acute respiratory distress syndrome (ARDS) caused by pneumonia.
[Athersys, Inc]
Press Release
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C3G Downregulation Induces the Acquisition of a Mesenchymal Phenotype That Enhances Aggressiveness of Glioblastoma Cells

The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
[Cell Death & Disease]
Manzano, S., Gutierrez-Uzquiza, A., Bragado, P., Sequera, C., Herranz, Ó., Rodrigo-Faus, M., Jauregui, P., Morgner, S., Rubio, I., Guerrero, C., & Porras, A. (2021). C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells. Cell Death & Disease, 12(4), 1–17. https://doi.org/10.1038/s41419-021-03631-w Cite
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Exosome-Eluting Stents for Vascular Healing after Ischemic Injury

The authors showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering]
Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., Dinh, P.-U., Cores, J., & Cheng, K. (2021). Exosome-eluting stents for vascular healing after ischaemic injury. Nature Biomedical Engineering, 1–15. https://doi.org/10.1038/s41551-021-00705-0 Cite
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Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15

Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
[Stem Cell Reports]
Song, C., Xu, W., Wu, H., Wang, X., Gong, Q., Liu, C., Liu, J., & Zhou, L. (2020). Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03136-y Cite
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A Composite Scaffold of Wharton’s Jelly and Chondroitin Sulphate Loaded with Human Umbilical Cord Mesenchymal Stem Cells Repairs Articular Cartilage Defects in Rat Knee

In vitro experiments involved identification of the human umbilical cord MSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of Wharton’s jelly (WJ) and chondroitin sulfate, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold.
[Journal of Materials Science-Materials in Medicine]
Li, Z., Bi, Y., Wu, Q., Chen, C., Zhou, L., Qi, J., Xie, D., Song, H., Han, Y., Qu, P., Zhang, K., Wu, Y., & Yin, Q. (2021). A composite scaffold of Wharton’s jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee. Journal of Materials Science: Materials in Medicine, 32(4), 36. https://doi.org/10.1007/s10856-021-06506-w Cite
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Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Attenuate the Inflammation of Severe Steroid-Resistant Asthma by Reshaping Macrophage Polarization

Investigators evaluated the effects of MSC-exosomes on airway hyper responsiveness, inflammation, histopathology, and macrophage polarization in severe, steroid-resistant asthma in mice.
[Stem Cell Research & Therapy]
Dong, B., Wang, C., Zhang, J., Zhang, J., Gu, Y., Guo, X., Zuo, X., Pan, H., Hsu, A. C.-Y., Wang, G., & Wang, F. (2021). Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. Stem Cell Research & Therapy, 12(1), 204. https://doi.org/10.1186/s13287-021-02244-6 Cite
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Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
[Cancer Biotherapy and Radiopharmaceuticals]
Ye, H., Pan, J., Gong, E., Cai, X., Xu, C., Li, Y., Zheng, H., & Cao, Z. (2021). Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis. Cancer Biotherapy and Radiopharmaceuticals. https://doi.org/10.1089/cbr.2020.3855 Cite
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