Bone Therapeutics announced it has treated the first patient for the ALLOB Phase IIb clinical study in patients with difficult-to-heal tibial fractures. The successful completion of Bone Therapeutics’ ALLOB trials would further demonstrate the promise of mesenchymal stromal derived cell therapies for the treatment of other underserved conditions.
6630899 nan items 1 apa default asc 1
Using single-cell transcriptome profiling, scientists reveal a striking remodelling of the epithelial and mesenchymal niches with a decrease in functional populations that are linked to the aetiology of chronic inflammatory disease.
Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
6630899 VFVXHQGR items 1 apa default asc 1
Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults. Despite high-risk factors being identified, no test for early detection is available. This study aimed to identify circulating nucleic acid sequences associated with serum extracellular vesicle preparations at the time of OS diagnosis, as a step towards an OS early detection assay.
6630899 X7VL8HRD items 1 apa default asc 1
Investigators suggest that YAP/TAZ pathway inhibition may prevent Ewing sarcoma (EwS) cell dissemination and metastasis, justifying further preclinical development of YAP/TAZ inhibitors for EwS treatment.
6630899 33LPQ8Z8 items 1 apa default asc 1
Bierbaumer, L., Katschnig, A. M., Radic-Sarikas, B., Kauer, M. O., Petro, J. A., Högler, S., Gurnhofer, E., Pedot, G., Schäfer, B. W., Schwentner, R., Mühlbacher, K., Kromp, F., Aryee, D. N. T., Kenner, L., Uren, A., & Kovar, H. (2021). YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells. Oncogenesis, 10(1), 1–13. https://doi.org/10.1038/s41389-020-00294-8 Cite
Scientists conducted a crossing study evaluating microvascular density, endothelial area, and Ki-67 proliferative index was reported for a series of formalin-fixed and paraffin-embedded tissue samples from 99 cat patients, affected by cat post-injection fibrosarcoma, by using a till ×400 magnification light microscopy.
6445212 BGWBQ66I items 1 apa default asc 1
Patruno, R., Passantino, G., Laface, C., Tinelli, A., Zito, A., Ruggieri, R., Luposella, F., Gadaleta, P., Laforgia, M., Lacitignola, L., Ammendola, M., Ranieri, G., & Zizzo, N. (2021). Microvascular Density, Endothelial Area, and Ki-67 Proliferative Index Correlate Each Other in Cat Post-Injection Fibrosarcoma. Cells, 10(1), 31. https://doi.org/10.3390/cells10010031 Cite
The authors explore the current literature on adiponectin in bone, looking in depth at the comparison between human and murine data in health, with age and in disease.
Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.
6445212 GH7EFJTL items 1 apa default asc 1
Scientists determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine]
6445212 R3CFUH7I items 1 apa default asc 1
Lanzoni, G., Linetsky, E., Correa, D., Cayetano, S. M., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., … Ricordi, C. (n.d.). Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0472 Cite
Scientists found that murine olfactory ecto-MSC-derived exosomes significantly enhanced the suppressive function of myeloid-derived suppressor cells by upregulating arginase expression and increasing ROS and NO levels.
[Cellular & Molecular Immunology]
6630899 BBX64XE6 items 1 apa default asc 1
Rui, K., Hong, Y., Zhu, Q., Shi, X., Xiao, F., Fu, H., Yin, Q., Xing, Y., Wu, X., Kong, X., Xu, H., Tian, J., Wang, S., & Lu, L. (2021). Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00587-3 Cite
To identify key drivers of metastasis, scientists studied human CCH-OS-D osteocarcinoma cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
[Cancer Gene Therapy]
6445212 CY22SNRI items 1 apa default asc 1
Lamhamedi-Cherradi, S.-E., Mohiuddin, S., Mishra, D. K., Krishnan, S., Velasco, A. R., Vetter, A. M., Pence, K., McCall, D., Truong, D. D., Cuglievan, B., Menegaz, B. A., Utama, B., Daw, N. C., Molina, E. R., Zielinski, R. J., Livingston, J. A., Gorlick, R., Mikos, A. G., Kim, M. P., & Ludwig, J. A. (2021). Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00281-6 Cite