Researchers comparatively assessed how the inflammatory environment present in acute respiratory distress syndrome (ARDS) lungs versus the lung environment present in healthy volunteers alters MSC behaviors.
[European Respiratory Journal]
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Enes, S. R., Hampton, T. H., Barua, J., McKenna, D. H., Santos, C. C. dos, Amiel, E., Ashare, A., Liu, K. D., Krasnodembskaya, A. D., English, K., Stanton, B. A., Rocco, P. R. M., Matthay, M. A., & Weiss, D. J. (2021). Healthy versus inflamed lung environments differentially effect MSCs. European Respiratory Journal. https://doi.org/10.1183/13993003.04149-2020 Cite
Scientists found that IL-1β enhanced adhesion of human MSCs via increased focal adhesion contacts in an α5β1 integrin-specific manner.
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Maynard, S. A., Pchelintseva, E., Zwi-Dantsis, L., Nagelkerke, A., Gopal, S., Korchev, Y. E., Shevchuk, A., & Stevens, M. M. (2021). IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells. Scientific Reports, 11(1), 6890. https://doi.org/10.1038/s41598-021-86315-x Cite
Mouse clonal MSCs were cultured on a Cytodex 3 microcarrier in a spinner flask for a suspension culture under hypoxia condition to increase mass productivity.
[Bioprocess and Biosystems Engineering]
Five groups of pigs were studied after 16 weeks of renovascular disease (RVD), RVD treated four weeks earlier with either percutaneous transluminal renal angioplasty or MSC-derived extracellular vesicles, and normal controls.
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Ferguson, C. M., Farahani, R. A., Zhu, X.-Y., Tang, H., Jordan, K. L., Saadiq, I. M., Lerman, A., Lerman, L. O., & Eirin, A. (2021). Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease. Cells, 10(4), 763. https://doi.org/10.3390/cells10040763 Cite
Athersys, Inc. announced that its partner HEALIOS K.K. has completed enrollment in the ONE-BRIDGE study in Japan evaluating MultiStem® in patients with acute respiratory distress syndrome (ARDS) caused by pneumonia.
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The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
[Cell Death & Disease]
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Manzano, S., Gutierrez-Uzquiza, A., Bragado, P., Sequera, C., Herranz, Ó., Rodrigo-Faus, M., Jauregui, P., Morgner, S., Rubio, I., Guerrero, C., & Porras, A. (2021). C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells. Cell Death & Disease, 12(4), 1–17. https://doi.org/10.1038/s41419-021-03631-w Cite
The authors showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering]
Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
[Stem Cell Reports]
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Song, C., Xu, W., Wu, H., Wang, X., Gong, Q., Liu, C., Liu, J., & Zhou, L. (2020). Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03136-y Cite
In vitro experiments involved identification of the human umbilical cord MSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of Wharton’s jelly (WJ) and chondroitin sulfate, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold.
[Journal of Materials Science-Materials in Medicine]
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Li, Z., Bi, Y., Wu, Q., Chen, C., Zhou, L., Qi, J., Xie, D., Song, H., Han, Y., Qu, P., Zhang, K., Wu, Y., & Yin, Q. (2021). A composite scaffold of Wharton’s jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee. Journal of Materials Science: Materials in Medicine, 32(4), 36. https://doi.org/10.1007/s10856-021-06506-w Cite
Investigators evaluated the effects of MSC-exosomes on airway hyper responsiveness, inflammation, histopathology, and macrophage polarization in severe, steroid-resistant asthma in mice.
[Stem Cell Research & Therapy]
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Dong, B., Wang, C., Zhang, J., Zhang, J., Gu, Y., Guo, X., Zuo, X., Pan, H., Hsu, A. C.-Y., Wang, G., & Wang, F. (2021). Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. Stem Cell Research & Therapy, 12(1), 204. https://doi.org/10.1186/s13287-021-02244-6 Cite
Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
[Cancer Biotherapy and Radiopharmaceuticals]
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