Scientists introduced a customizable collagen I-hyaluronic acid (COL-HA)-based hydrogel platform for the encapsulation of MSCs. Cells encapsulated within COL-HA showed a significant expansion of their secretory profile compared to MSCs cultured in standard (2D) cell culture dishes or encapsulated in other hydrogels.
6445212 6NPNKRW5 items 1 apa default asc 1
Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis.
6445212 RQNIV5UU items 1 apa default asc 1
Scientists focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a calcium-phosphate biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes.
6445212 PM3DDC3X items 1 apa default asc 1
The authors identified growth hormone receptor is mainly expressed in mesenchymal cells, and its expression is substantially decreased in idiopathic pulmonary fibrosis lungs.
6445212 GVV9S2JC items 1 apa default asc 1
Investigators summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.
[Cell Death & Disease]
The authors examined the safety and efficacy of human umbilical cord mesenchymal stem cell infusion for immune non-responder patients with chronic HIV-1 infection, who represented an unmet medical need even in the era of efficient antiretroviral therapy.
[Signal Transduction and Targeted Therapy]
6445212 KCQIAHMM items 1 apa default asc 1
Wang, L., Zhang, Z., Xu, R., Wang, X., Shu, Z., Chen, X., Wang, S., Liu, J., Li, Y., Wang, L., Zhang, M., Yang, W., Wang, Y., Huang, H., Tu, B., Liang, Z., Li, L., Li, J., Hou, Y., … Wang, F.-S. (2021). Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS: a multicenter randomized controlled trial. Signal Transduction and Targeted Therapy, 6(1), 1–8. https://doi.org/10.1038/s41392-021-00607-2 Cite
Calidi Biotherapeutics, Inc. announced its partnership with GenScript ProBio for assistance in the advertisement and distribution of Calidi’s proprietary technology platform: SuperNova-1 (SNV-1). The SNV-1 platform is composed of allogeneic, adipose-derived-MSC loaded with an oncolytic agent such as the vaccinia virus.
[Calidi Biotherapeutics, Inc. (Business Wire, Inc.)]
6445212 nan items 1 apa default asc 1
Investigators describe the advances in fat tissue engineering applied to regenerative surgery, through the use of adipose-derived-MSCs, stromal vascular fraction contained in lipofilling/fat graft in wound healing and scar treatment.
[Stem Cell Research & Therapy]
6445212 TZNFWS7N items 1 apa default asc 1
The authors focus on the reasons why articular cartilage (AC) cannot regenerate itself in spite of potential self-repair capacity and summarize the latest developments of the three key components in the field of endogenous AC regeneration.
[Aging and Disease]
6445212 2IFLDVRH items 1 apa default asc 1
The authors review how dysregulation of tissue-level force increases risk of malignancy, promotes tumor progression, and can induce a stem-like phenotype in tumor cells to drive tumor aggression and treatment resistance.
6445212 28NJ9FG9 items 1 apa default asc 1
Novartis AG has announced the first published mature overall survival and updated overall response rate data following treatment with Tabrecta® in adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to MET exon 14 skipping (METex14).
6445212 nan items 1 apa default asc 1