ASCs and Their Role in Obesity and Metabolic Diseases

The authors discuss adiposopathy with a focus on adiponiche dysfunction, and underline the mechanisms that control adipose tissue expansion and energy balance.
[Trends in Endocrinology and Metabolism]
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Mesenchymal Stromal Cells: Putative Microenvironmental Modulators Become Cell Therapy

Scientists discuss potential mechanisms of action for the therapeutic effects of MSC transplantation, experimental models that dissect tissue modulating function of MSCs, and approaches for identifying MSC effects in vivo by integrating biomarkers of disease and MSC activity.
[Cell Stem Cell]
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Additional Benefit of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Therapy on Sepsis Syndrome-Associated Acute Kidney Injury in Rat Treated with Antibiotic

Investigators tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells would offer an additional benefit to the rodent with acute kidney injury associated sepsis syndrome undergoing ciprofloxacin therapy.
[Stem Cell Research & Therapy]
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Whitehead Institute Member Pulin Li Receives NIH New Innovator Award

Whitehead Institute Member Pulin Li has received a New Innovator Award from the National Institutes of Health (NIH). Li’s New Innovator Award will fund her investigations of how the different cell types in the body interact to form organs.
[Whitehead Institute]
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Growth and Mineralization of Osteoblasts from Mesenchymal Stem Cells on Microporous Membranes: Epithelial-Like Growth with Transmembrane Resistance and pH Gradient

MSCs were characterized by flow cytometry with more than 90% CD44 and 75% Sca-1 labeling. Mineralization was validated with paracellular alkaline phosphatase activity, collagen birefringence, and mineral deposition confirming MSCs identity.
[Biochemical and Biophysical Research Communications]
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Comparing the Renoprotective Effects of BM-MSCs versus BM-MSC-Exosomes, When Combined with an Anti-Fibrotic Drug, in Hypertensive Mice

Scientists determined whether serelaxin (RLX) could enhance the therapeutic efficacy of bone-marrow-derived- mesecnymal stem cell-exosomes (BM-MSC-EXO), and compared the renoprotective effects of RLX and BM-MSC-EXO versus RLX and BM-MSCs in mice with hypertensive CKD.
[Biomedicine & Pharmacotherapy]
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Tailoring the Proliferation of Fibroblast Cells by Multiresponsive and Thermosensitive Stem Cells Composite F127 Hydrogel Containing Folic acid.MgO:ZnO/Chitosan Hybrid Microparticles for Skin Regeneration

The authors showed that F127 hydrogel containing FMZC is a suitable and nontoxic construct for encapsulation of MSCs in the presence of lysozyme and UVA irradiation, bearing high stem cell viability and proliferation.
[European Journal of Pharmaceutical Sciences]
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Hop2 Interacts with the Transcription Factor CEBPα and Suppresses Adipocyte Differentiation

These in vitro data suggest that Hop2 inhibited adipogenesis by suppressing CEBP-mediated transactivation. Consistent with a negative role for Hop2 in adipogenesis, ablation of Hop2 in mice led to increased body weight, adipose volume, adipocyte size, and adipogenic marker gene expression.
[Journal of Biological Chemistry]
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UC Riverside Receives $5M CIRM Grant to Train Scientists in Stem Cell Research

The University of California, Riverside, has received a grant of $5 million from the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians in stem cell research.
[University of California, Riverside]
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Overview of Malignant Soft-Tissue Sarcomas of the Limbs

Following a review of over 4,000 adult patients with limb sarcoma from our specialist soft-tissue tumour database, scientists summarize the literature and their imaging findings, with emphasis on radiological hallmarks that can aide in diagnosis and management.
[Clinical Radiology]
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Stem Cell Therapy in Liver Regeneration: Focus on Mesenchymal Stem Cells and Induced Pluripotent Stem Cells

Owing to the recent developments in mesenchymal stem cells and induced pluripotent stem cells, combined with emerging technologies including graphene, nano-biomaterials, and gene editing, precision medicine and individualized clinical treatment may be realized in the near future.
[Pharmacology & Therapeutics]
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