Fetal Circulating Human Resistin Increases in Diabetes during Pregnancy and Impairs Placental Mitochondrial Biogenesis

Fetal resistin levels were measured in cord blood from pregnancies with and without maternal diabetes. Secretion of resistin from cord blood mononuclear cells was measured.
[Molecular Medicine]
Jiang, S., Teague, A. M., Tryggestad, J. B., Lyons, T. J., & Chernausek, S. D. (2020). Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Molecular Medicine, 26(1), 76. https://doi.org/10.1186/s10020-020-00205-y Cite
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The Epigenomics of Sarcoma

Scientists review current and potential future approaches for the development of sarcoma therapies based on this emerging understanding of chromatin dysregulation.
[Nature Reviews Cancer]
Nacev, B. A., Jones, K. B., Intlekofer, A. M., Yu, J. S. E., Allis, C. D., Tap, W. D., Ladanyi, M., & Nielsen, T. O. (2020). The epigenomics of sarcoma. Nature Reviews Cancer, 1–16. https://doi.org/10.1038/s41568-020-0288-4 Cite
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Intraarticular Injection of Liposomal Adenosine Reduces Cartilage Damage in Established Murine and Rat Models of Osteoarthritis

Scientists report that injection of liposomal suspensions of either adenosine or a selective A2AR agonist, CGS21680, significantly reduced osteoarthritis (OA) cartilage damage in a murine model of obesity-induced OA.
[Scientific Reports]
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Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate-Severity Disc Degeneration in Goats

Researchers evaluated the efficacy of a combined triple interpenetrating network hydrogel and mesenchymal stem cell therapy targeting moderate-severity disc degeneration in a clinically relevant goat model.
[Tissue Engineering]
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TYME Announces Outcome of Interim Futility Review for HopES Sarcoma Phase II Study

Tyme Technologies, Inc. announced a positive outcome of an interim futility review for the HopES Sarcoma Phase II clinical trial that is evaluating TYME’s lead cancer metabolism-based candidate, SM-88, as a potential oral treatment for patients with Ewing’s Sarcoma and other high-risk sarcomas.
[Tyme Technologies, Inc. (BusinessWire, Inc.)]
Press Release

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Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes

To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
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Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome

The authors focus on the therapeutic potential of mesenchymal stem/stromal cells (MSCs). MSCs are available from several tissues, including bone marrow, umbilical cord, and adipose tissue.
[Seminars in Respiratory and Critical Care Medicine]
Byrnes, D., Masterson, C. H., Artigas, A., & Laffey, J. G. (2020). Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome. Seminars in Respiratory and Critical Care Medicine. https://doi.org/10.1055/s-0040-1713422 Cite
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Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Look into Treatment Mechanism and Therapeutic Potential

Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
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Exosomes — Beyond Stem Cells for Cardiac Protection and Repair

Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
[Stem Cells]
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Promotion of the Immunomodulatory Properties and Osteogenic Differentiation of Adipose‐Derived Mesenchymal Stem Cells In Vitro by Lentivirus‐Mediated miR‐146a Sponge Expression

Investigators employed miRNA sponges that were forcibly expressed using a lentiviral vector to knock‐down the expression of miR‐146a in human adipose‐derived stem cells.
[Journal of Tissue Engineering and Regenerative Medicine]
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Doxycycline Restores the Impaired Osteogenic Commitment of Diabetic-Derived Bone Marrow Mesenchymal Stromal Cells by Increasing the Canonical WNT Signaling

Researchers aimed to address the modulatory capability and associated molecular signaling of a low dosage doxycycline – a semi-synthetic tetracycline, in the functional activity of osteoblastic progenitor cells, established from a translational diabetic experimental model.
[Molecular and Cellular Endocrinology]
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HDAC Inhibitors Tune miRNAs in Extracellular Vesicles of Dystrophic Muscle-Resident Mesenchymal Cells

Investigators showed that extracellular vesicles released by mesenchymal cells mediated microRNAtransfer to muscle stem cells.
[EMBO Reports]
Sandonà, M., Consalvi, S., Tucciarone, L., De Bardi, M., Scimeca, M., Angelini, D. F., Buffa, V., D’Amico, A., Bertini, E. S., Cazzaniga, S., Bettica, P., Bouché, M., Bongiovanni, A., Puri, P. L., & Saccone, V. (2020). HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells. EMBO Reports, n/a(n/a), e50863. https://doi.org/10.15252/embr.202050863 Cite
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