Fetal resistin levels were measured in cord blood from pregnancies with and without maternal diabetes. Secretion of resistin from cord blood mononuclear cells was measured.
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Scientists review current and potential future approaches for the development of sarcoma therapies based on this emerging understanding of chromatin dysregulation.
[Nature Reviews Cancer]
Scientists report that injection of liposomal suspensions of either adenosine or a selective A2AR agonist, CGS21680, significantly reduced osteoarthritis (OA) cartilage damage in a murine model of obesity-induced OA.
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Researchers evaluated the efficacy of a combined triple interpenetrating network hydrogel and mesenchymal stem cell therapy targeting moderate-severity disc degeneration in a clinically relevant goat model.
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Tyme Technologies, Inc. announced a positive outcome of an interim futility review for the HopES Sarcoma Phase II clinical trial that is evaluating TYME’s lead cancer metabolism-based candidate, SM-88, as a potential oral treatment for patients with Ewing’s Sarcoma and other high-risk sarcomas.
[Tyme Technologies, Inc. (BusinessWire, Inc.)]
To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
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Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
Continue reading “Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes”
The authors focus on the therapeutic potential of mesenchymal stem/stromal cells (MSCs). MSCs are available from several tissues, including bone marrow, umbilical cord, and adipose tissue.
[Seminars in Respiratory and Critical Care Medicine]
Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
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Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
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Investigators employed miRNA sponges that were forcibly expressed using a lentiviral vector to knock‐down the expression of miR‐146a in human adipose‐derived stem cells.
[Journal of Tissue Engineering and Regenerative Medicine]
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Researchers aimed to address the modulatory capability and associated molecular signaling of a low dosage doxycycline – a semi-synthetic tetracycline, in the functional activity of osteoblastic progenitor cells, established from a translational diabetic experimental model.
[Molecular and Cellular Endocrinology]
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Investigators showed that extracellular vesicles released by mesenchymal cells mediated microRNAtransfer to muscle stem cells.
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Sandonà, M., Consalvi, S., Tucciarone, L., De Bardi, M., Scimeca, M., Angelini, D. F., Buffa, V., D’Amico, A., Bertini, E. S., Cazzaniga, S., Bettica, P., Bouché, M., Bongiovanni, A., Puri, P. L., & Saccone, V. (2020). HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells. EMBO Reports, n/a(n/a), e50863. https://doi.org/10.15252/embr.202050863 Cite