Category Archives: Mesenchymal Cell

Mesenchymal Cell News is an online publication and email newsletter that delivers updates on the latest research in the mesenchymal stem cell field.
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Mesenchymal Cell News is a weekly email newsletter covering topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.

Allogeneic Administration of Human Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants

Umbilical cord-MSC culture was conducted under xeno- and serum-free conditions. Four patients with established bronchopulmonary dysplasia were enrolled in this study between May 25, 2018, and December 31, 2018.
[Journal of Translational Medicine]
Nguyen, L. T., Trieu, T. T. H., Bui, H. T. H., Hoang, V. T., Nguyen, A. T. T., Trinh, N. T. H., Nguyen, K. T., & Hoang, D. M. (2020). Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants. Journal of Translational Medicine, 18(1), 398. https://doi.org/10.1186/s12967-020-02568-6 Cite
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IL-8/CXCR2 Mediates Tropism of Human Bone Marrow-Derived Mesenchymal Stem Cells toward CD133+/CD44+ Colon Cancer Stem Cells

Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133−/CD44−, and CD133+/CD44+ colon cancer cells in vitro.
[Journal of Cellular Physiology]
Ma, X., Chen, J., Liu, J., Xu, B., Liang, X., Yang, X., Feng, Y., Liang, X., & Liu, J. (n.d.). IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+ Colon cancer stem cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30080 Cite
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Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa

Scientists summarize the current neuroscientific evidence regarding the effectiveness of cell therapies in Retinitis pigmentosa, especially those based on MSCs, and they focus on their therapeutic action: limitation of both oxidative stress and apoptotic processes triggered by the disease and promotion of cell survival.
[Antioxidants]
Limoli, P. G., Vingolo, E. M., Limoli, C., & Nebbioso, M. (2020). Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa. Antioxidants, 9(10), 983. https://doi.org/10.3390/antiox9100983 Cite
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Mesenchymal Stem Cells-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression

The authors investigated the effect of a standard of care chemotherapeutic agent Doxorubicin (Dox) on MSC-exo and its contribution to the development of Dox resistance in breast cancer cells (BCs). They found that the exosome secreted by Dox-treated MSC induced a higher degree of Dox resistance in BCs when compared with non-treated MSC-exo.
[Molecular Therapy-Oncolytics]
Luo, T., Liu, Q., Tan, A., Duan, L., Jia, Y., Nong, L., Tang, J., Zhou, W., Xie, W., Lu, Y., Yu, Q., & Liu, Y. (2020). Mesenchymal stem cells-secreted exosome promotes chemoresistance in breast cancer via enhancing miR-21-5p-mediated S100A6 expression. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.10.008 Cite
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The Crucial Choice of Reference Genes: Identification of miR-191-5p for Normalization of miRNAs Expression in Bone Marrow Mesenchymal Stromal Cell and HS27a/HS5 Cell Lines

Scientists identified appropriate reference genes for normalization of miRNA expression in bone marrow-MSCs and HS27a and HS5 cell lines in various conditions including normoxia, hypoxia, co-culture, as model for the hematopoietic niche and after induced differentiation as model for regenerative medicine.
[Scientific Reports]
Costé, É., & Rouleux-Bonnin, F. (2020). The crucial choice of reference genes: identification of miR-191-5p for normalization of miRNAs expression in bone marrow mesenchymal stromal cell and HS27a/HS5 cell lines. Scientific Reports, 10(1), 17728. https://doi.org/10.1038/s41598-020-74685-7 Cite
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Bone Therapeutics’ Allogeneic Cell Therapy Product, ALLOB, Shows 90% Fusion Rate at 24 months in Phase IIa Study in Lumbar Spinal Fusion

Bone Therapeutics has announced positive 24-month follow-up results for the Phase IIa study with the allogeneic cell therapy product, ALLOB, in patients undergoing lumbar spinal fusion procedures. ALLOB is their off-the-shelf allogeneic cell therapy platform consisting of human allogeneic bone-forming cells derived from cultured bone marrow MSCs from healthy adult donors.
[Bone Therapeutics S.A.]
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Aryl Hydrocarbon Receptor in Mesenchymal Stromal Cells: New Frontiers in AhR Biology

The aryl hydrocarbon receptor has potential to be an attractive target in both endogenous and culture‐adapted MSCs for novel therapeutics to treat inflammation and other age‐related disorders.
[FEBS Journal]
Abney, K. K., & Galipeau, J. (n.d.). Aryl Hydrocarbon Receptor in Mesenchymal Stromal Cells: New Frontiers in AhR Biology. The FEBS Journal, n/a(n/a). https://doi.org/10.1111/febs.15599 Cite
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Potential Application of Mesenchymal Stem Cells and Their Exosomes in Lung Injury: An Emerging Therapeutic Option for COVID-19 Patients

The authors shed light on the mechanistic view of MSC therapeutic role based on preclinical and clinical studies on acute lung injury and ARDS; therefore, offering a unique correlation and applicability in COVID-19 patients. They further highlight the challenges and opportunities in the use of MSC-based therapy.
[Stem Cell Research & Therapy]
Al-Khawaga, S., & Abdelalim, E. M. (2020). Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients. Stem Cell Research & Therapy, 11(1), 437. https://doi.org/10.1186/s13287-020-01963-6 Cite
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Tenascin C Promotes Cancer Cell Plasticity in Mesenchymal Glioblastoma

Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells.
[Oncogene]
Angel, I., Pilo Kerman, O., Rousso-Noori, L., & Friedmann-Morvinski, D. (2020). Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01506-6 Cite
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Regional Hyperthermia Enhances Mesenchymal Stem Cell Recruitment to Tumor Stroma: Implications for Mesenchymal Stem Cell-Based Tumor Therapy

The authors describe the enhanced recruitment of adoptively applied theranostic sodium iodide symporter-expressing MSCs to tumors in response to regional hyperthermia.
[Molecular Therapy]
Tutter, M., Schug, C., Schmohl, K. A., Urnauer, S., Kitzberger, C., Schwenk, N., Petrini, M., Zach, C., Ziegler, S., Bartenstein, P., Weber, W., Multhoff, G., Wagner, E., Lindner, L. H., Nelson, P. J., & Spitzweg, C. (2020). Regional hyperthermia enhances mesenchymal stem cell recruitment to tumor stroma: Implications for mesenchymal stem cell-based tumor therapy. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.10.009 Cite
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LncRNA SNHG10 Promotes the Proliferation and Invasion of Osteosarcoma via Wnt/β-Catenin Signaling

In vitro experiments (including colony formation, CCK-8, wound healing and transwell assays) and in vivo experiments indicated that down-regulation of SNHG10 significantly suppressed the proliferation and invasion of osteosarcoma cells
[Molecular Therapy-Nucleic Acids]
Zhu, S., Liu, Y., Wang, X., Wang, J., & Xi, G. (2020). LncRNA SNHG10 promotes the proliferation and invasion of osteosarcoma via Wnt/β-catenin signaling. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.010 Cite
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