Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Ultragenyx and Kyowa Kirin Announce US FDA Approval of Crysvita® (Burosumab) for the Treatment of Tumor-Induced Osteomalacia (TIO)

Ultragenyx Pharmaceutical, Inc. and Kyowa Kirin Co., Ltd. announced that the FDA has approved Crysvita® for the treatment of fibroblast growth factor 23-related hypophosphatemia in tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors that cannot be curatively resected or localized in adults and pediatric patients two years of age and older.
[Ultragenyx Pharmaceutical, Inc.]
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Runx2 Regulates Mouse Tooth Root Development via Activation of WNT Inhibitor Notum

Investigators provided in vivo evidence that Runx2 played a crucial role in tooth root development and in regulating the differentiation of root progenitor cells.
[Journal of Bone and Mineral Research]
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Berberine Mediates Root Remodeling in an Immature Tooth with Apical Periodontitis by Regulating Stem Cells from Apical Papilla Differentiation

Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity, mineralization ability, and gene expression of osteogenic makers.
[International Journal of Oral Science]
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Induction of ASC Pyroptosis Requires Gasdermin D or Caspase-1/11-Dependent Mediators and IFNβ from Pyroptotic Macrophages

Scientists found that LPS, flagellin, dsDNA, nigericin, or LPS combined with nigericin could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells.
[Cell Death & Disease]
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Geriatric Fragility Fractures are Associated with a Human Skeletal Stem Cell Defect

Functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity.
[Aging Cell]
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TGF-β-Driven Downregulation of the Transcription Factor TCF7L2 affects Wnt/β-Catenin Signaling in PDGFRα+ Fibroblasts

The authors investigated whether damage-induced transforming growth factor β signaling impaired the expression and function of T-cell factor 4, using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors.
[Journal of Cell Science]
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Exosomes: Roles and Therapeutic Potential in Osteoarthritis

The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discusses the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
[Bone Research]
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Fibronectin 1 Activates WNT/β-Catenin Signaling to Induce Osteogenic Differentiation via Integrin β1 Interaction

Researchers report that fibronectin 1 promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts.
[Laboratory investigation]
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Piezo2 Expressed in Proprioceptive Neurons Is Essential for Skeletal Integrity

While loss of Piezo2 in chondrogenic or osteogenic lineages did not lead to human-like skeletal abnormalities, its loss in proprioceptive neurons led to spine malalignment and hip dysplasia.
[Nature Communications]
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