Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful (MSC differentiation. Researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation.
[Cell Death & Disease]
The authors explored the potential involvement of ALKBH5 in osteosarcoma and deciphered the underlying cellular/molecular mechanisms. They discovered downregulated levels of demethylase ALKBH5 were correlated with increased m6A methylation in osteosarcoma cells/tissues compared with normal osteoblasts cells/tissues.
[Cell Death & Disease]
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Yuan, Y., Yan, G., He, M., Lei, H., Li, L., Wang, Y., He, X., Li, G., Wang, Q., Gao, Y., Qu, Z., Mei, Z., Shen, Z., Pu, J., Wang, A., Zhao, W., Jiang, H., Du, W., & Yang, L. (2021). ALKBH5 suppresses tumor progression via an m 6 A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03315-x Cite
Bone Therapeutics announced it has treated the first patient for the ALLOB Phase IIb clinical study in patients with difficult-to-heal tibial fractures. The successful completion of Bone Therapeutics’ ALLOB trials would further demonstrate the promise of mesenchymal stromal derived cell therapies for the treatment of other underserved conditions.
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Using single-cell transcriptome profiling, scientists reveal a striking remodelling of the epithelial and mesenchymal niches with a decrease in functional populations that are linked to the aetiology of chronic inflammatory disease.
Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
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Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults. Despite high-risk factors being identified, no test for early detection is available. This study aimed to identify circulating nucleic acid sequences associated with serum extracellular vesicle preparations at the time of OS diagnosis, as a step towards an OS early detection assay.
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Investigators suggest that YAP/TAZ pathway inhibition may prevent Ewing sarcoma (EwS) cell dissemination and metastasis, justifying further preclinical development of YAP/TAZ inhibitors for EwS treatment.
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Bierbaumer, L., Katschnig, A. M., Radic-Sarikas, B., Kauer, M. O., Petro, J. A., Högler, S., Gurnhofer, E., Pedot, G., Schäfer, B. W., Schwentner, R., Mühlbacher, K., Kromp, F., Aryee, D. N. T., Kenner, L., Uren, A., & Kovar, H. (2021). YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells. Oncogenesis, 10(1), 1–13. https://doi.org/10.1038/s41389-020-00294-8 Cite
Scientists conducted a crossing study evaluating microvascular density, endothelial area, and Ki-67 proliferative index was reported for a series of formalin-fixed and paraffin-embedded tissue samples from 99 cat patients, affected by cat post-injection fibrosarcoma, by using a till ×400 magnification light microscopy.
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Patruno, R., Passantino, G., Laface, C., Tinelli, A., Zito, A., Ruggieri, R., Luposella, F., Gadaleta, P., Laforgia, M., Lacitignola, L., Ammendola, M., Ranieri, G., & Zizzo, N. (2021). Microvascular Density, Endothelial Area, and Ki-67 Proliferative Index Correlate Each Other in Cat Post-Injection Fibrosarcoma. Cells, 10(1), 31. https://doi.org/10.3390/cells10010031 Cite
The authors explore the current literature on adiponectin in bone, looking in depth at the comparison between human and murine data in health, with age and in disease.
Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.
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Scientists determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine]
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Lanzoni, G., Linetsky, E., Correa, D., Cayetano, S. M., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., … Ricordi, C. (n.d.). Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0472 Cite