Single-Cell Transcriptome Profiling Reveals Molecular Heterogeneity in Human Umbilical Cord Tissue and Culture-Expanded Mesenchymal Stem Cells

The heterogeneity and the characteristics of cultured umbilical cord MSCs and the cognate human umbilical cord tissue at single‐cell resolution remains poorly defined.
[FEBS Journal]
Wang, Q., Li, J., Wang, S., Deng, Q., Wang, K., Dai, X., An, Y., Dong, G., Ke, W., Chen, F., Liu, L., Yang, H., Du, Y., Zhao, W., & Shang, Z. (n.d.). Single-cell transcriptome profiling reveals molecular heterogeneity in human umbilical cord tissue and culture-expanded mesenchymal stem cells. The FEBS Journal, n/a(n/a). https://doi.org/https://doi.org/10.1111/febs.15834 Cite
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Stem Cell-Based Approaches in Cardiac Tissue Engineering: Controlling the Microenvironment for Autologous Cells

The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy]
Augustine, R., Dan, P., Hasan, A., Khalaf, I. M., Prasad, P., Ghosal, K., Gentile, C., McClements, L., & Maureira, P. (2021). Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy, 138, 111425. https://doi.org/10.1016/j.biopha.2021.111425 Cite
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Impaired Regenerative Capacity and Senescence-Associated Secretory Phenotype in Mesenchymal Stromal Cells from Samples of Patients with Aseptic Joint Arthroplasty Loosening

Investigators compared the regenerative and differentiation capacity of MSCs derived from patients undergoing primary total hip arthroplasty to MSC derived from patients undergoing revision surgery after aseptic loosening of total hip and knee joint implants
[Journal of Orthopaedic Research]
Regina, E., Manuel, W., Clemens, B., Mike, W., Marietta, H., Sigrid, M.-D., Melanie, K., Franz, J., & Maximilian, R. (n.d.). Impaired regenerative capacity and senescence-associated secretory phenotype in mesenchymal stromal cells from samples of patients with aseptic joint arthroplasty loosening. Journal of Orthopaedic Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jor.25041 Cite
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Lyophilized Powder of Mesenchymal Stem Cell Supernatant Attenuates Acute Lung Injury through the IL-6–P-STAT3–p63–JAG2 Pathway

Intratracheal bleomycin was used to induce acute lung injury in mice, and intratracheal MSCs in a supernatant lyophilized powder was administered as a treatment.
[Stem Cell Research & Therapy]
Peng, W., Chang, M., Wu, Y., Zhu, W., Tong, L., Zhang, G., Wang, Q., Liu, J., Zhu, X., Cheng, T., Li, Y., Chen, X., Weng, D., Liu, S., Zhang, H., Su, Y., Zhou, J., Li, H., & Song, Y. (2021). Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6–p-STAT3–p63–JAG2 pathway. Stem Cell Research & Therapy, 12(1), 216. https://doi.org/10.1186/s13287-021-02276-y Cite
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Effect of Resveratrol and Mesenchymal Stem Cell Monotherapy and Combined Treatment in Management of Osteoporosis in Ovariectomized Rats: Role of SIRT1/FOXO3a and Wnt/β-Catenin Pathways

Researchers explored the effects and molecular mechanisms of resveratrol and MSC individual and combined treatment in management of osteoporosis in ovariectomized rats.
[Archives of Biochemistry and Biophysics]
Elseweidy, M. M., El-Swefy, S. E., Shaheen, M. A., Baraka, N. M., & Hammad, S. K. (2021). Effect of resveratrol and mesenchymal stem cell monotherapy and combined treatment in management of osteoporosis in ovariectomized rats: Role of SIRT1/FOXO3a and Wnt/β-catenin pathways. Archives of Biochemistry and Biophysics, 108856. https://doi.org/10.1016/j.abb.2021.108856 Cite
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The Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Hepatic Regeneration in Miniature Pigs after Liver Ischemia-Reperfusion Combined with Partial Resection

24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
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The Effect of Bone Marrow-Derived Mesenchymal Stem Cell Co-Transplantation with Hematopoietic Stem Cells on Liver Fibrosis Alleviation and Survival in Patients with Class III β-Thalassemia Major

The authors evaluated the effect of co-transplantation of bone marrow-derived MSC with HSCs on the liver fibrosis alleviation and transplant outcomes in class III beta-thalassemia major.
[Stem Cell Research & Therapy]
Rostami, T., Kasaeian, A., Maleki, N., Nikbakht, M., Kiumarsi, A., Tavangar, S. M., Taheri, A. P. H., Mousavi, S. A., & Ghavamzadeh, A. (2021). The effect of bone marrow-derived mesenchymal stem cell co-transplantation with hematopoietic stem cells on liver fibrosis alleviation and survival in patients with class III β-thalassemia major. Stem Cell Research & Therapy, 12(1), 213. https://doi.org/10.1186/s13287-021-02242-8 Cite
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Sorrento Announces Updated Positive Results of Phase Ib Study of COVI-MSC™ for Treatment of ICU COVID-19 Patients

Sorrento Therapeutics, Inc. announced updated positive results from its Phase Ib study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress (ARD) or acute respiratory distress syndrome (ARDS).
[Sorrento Therapeutics, Inc. ]
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Cynata Expands MEND Clinical Trial in COVID-19 and Respiratory Failure

Cynata Therapeutics Limited announced that it has received ethics committee approval to expand recruitment criteria in its active MEseNchymal coviD-19 (MEND) clinical trial.
[Cynata Therapeutics Limited (GlobeNewswire)]
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NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair

In vitro, nerve growth factor significantly improved the proliferation of human umbilical cord MSCs and mitigated cytotoxicity and apoptosis under hypoxic injury.
[American Journal of Physiology-Heart and Circulatory Physiology]
Luo, W., Gong, Y., Qiu, F., Yuan, Y., Jia, W., Liu, Z., & Gao, L. (2021). NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00855.2020 Cite
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Tooth Repair and Regeneration: Potential of Dental Stem Cells

Investigators discuss how key signaling pathways regulating natural tooth development are being exploited for applications in tissue engineering and regenerative medicine and dentistry approaches for vital tooth regeneration.
[Trends in Molecular Medicine]
Zhang, W., & Yelick, P. C. (2021). Tooth Repair and Regeneration: Potential of Dental Stem Cells. Trends in Molecular Medicine, 0(0). https://doi.org/10.1016/j.molmed.2021.02.005 Cite
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