Scientists found that Ryk—an atypical Wnt receptor with a pseudokinase domain—had a Wnt-modulating effect in bone marrow stromal cells to control hematopoiesis-supporting activities.
[Experimental and Molecular Medicine]
C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
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Researchers demonstrated the biophysical and biochemical effects of preconditioning human mesenchymal stem cells for 96 hours on a three-dimensional extracellular matrix-based microgel platform.
[Proceedings of the National Academy of Sciences of the United States of America]
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Thomas, D., Marsico, G., Isa, I. L. M., Thirumaran, A., Chen, X., Lukasz, B., Fontana, G., Rodriguez, B., Marchetti-Deschmann, M., O’Brien, T., & Pandit, A. (2020). Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2008245117 Cite
Cell viability of human dental pulp stem cells cultured three-dimensionally in gelatin-based and fibrin-based scaffolds was evaluated by MTT and live/dead assay.
The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
Scientists showed that transgene expression enhancement was mediated by transcriptional activation of endogenous human MSC genes by the cytosolic glucocorticoid receptor.
[Molecular Therapy-Methods & Clinical Development]
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Hamann, A., Kozisek, T., Broad, K., & Pannier, A. K. (2020). Glucocorticoid Priming of Nonviral Gene Delivery to Human Mesenchymal Stem Cells Increases Transfection by Reducing Induced Stresses. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.07.014 Cite
When co-culturing osteosarcoma (OS) cells with bone marrow-derived mesenchymal stem cells (BMSCs) in vitro, scientists validated that oncogenic LCP1 in OS was transferred from BMSCs via exosomes.
[Molecular Therapy-Nucleic Acids]
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Ge, X., Liu, W., Zhao, W., Feng, S., Duan, A., Ji, C., Shen, K., Liu, W., Zhou, J., Jiang, D., Rong, Y., Gong, F., Wang, J., Xu, Z., Li, X., Fan, J., Wei, Y., Bai, J., & Cai, W. (2020). Exosomal transfer of LCP1 promotes osteosarcoma cell tumorigenesis and metastasis by activating the JAK2/STAT3 signaling pathway. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.07.025 Cite
Investigators found that aberrant expression of LCP1 could induce the proliferation and metastasis of osteosarcoma cells in vitro and in vivo by destabilizing neuregulin receptor degradation protein-1 and subsequently activating the JAK2/STAT3 signaling pathway.
[Molecular Therapy-Nucleic Acids]
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Mi, B., Yan, C., Xue, H., Chen, L., Panayi, A. C., Hu, L., Hu, Y., Cao, F., Sun, Y., Zhou, W., Xiong, Y., & Liu, G. (2020). Inhibition of circulating miR-194-5p reverses osteoporosis through Wnt5a/β-catenin signaling-dependent induction of osteogenic differentiation. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.07.023 Cite
Researchers describe the considerable effort taken to overcome chemotherapy resistance in sarcoma cells.
[Molecular Diagnosis & Therapy]
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Mastoraki, A., Schizas, D., Vlachou, P., Melissaridou, N. M., Charalampakis, N., Fioretzaki, R., Kole, C., Savvidou, O., Vassiliu, P., & Pikoulis, E. (2020). Assessment of Synergistic Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Sarcoma. Molecular Diagnosis & Therapy. https://doi.org/10.1007/s40291-020-00487-2 Cite
The authors discuss the major clinical challenges with MSC therapies, the details of these challenges, and the potential bioengineering approaches that leverage the unique biology of MSCs to overcome the challenges and achieve more potent and versatile therapies.
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Levy, O., Kuai, R., Siren, E. M. J., Bhere, D., Milton, Y., Nissar, N., Biasio, M. D., Heinelt, M., Reeve, B., Abdi, R., Alturki, M., Fallatah, M., Almalik, A., Alhasan, A. H., Shah, K., & Karp, J. M. (2020). Shattering barriers toward clinically meaningful MSC therapies. Science Advances, 6(30), eaba6884. https://doi.org/10.1126/sciadv.aba6884 Cite
Scientists review the immunomodulatory aspects of naïve and engineered MSCs, and discuss strategies for increasing the potential of successfully using MSCs in clinical settings.
[Trends in Pharmacological Sciences]