Sorrento Adds Mesenchymal Stem Cell Program (MSC), Cleared for Phase I Trial by the FDA to the Pipeline of COVID-19 Focused Rescue Therapies

Sorrento Therapeutics, Inc. announced that it has entered into an exclusive license agreement with Personalized Stem Cells, Inc. to acquire global rights to its adipose-derived MSCs for patients suffering from acute respiratory distress syndrome associated with COVID-19, which have been cleared for a Phase I clinical trial by the FDA.
[Sorrento Therapeutics, Inc.]
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Sequential Paracrine Mechanisms Are Necessary for the Therapeutic Benefits of Stem Cell Therapy

To identify the active paracrine factors released by macrophages in response to stimulation by mesenchymal stem cell (MSC) conditioned media scientists used an antibody array; identifying increased expression of the angiogenesis-related proteins stromal cell-derived factor 1 and plasminogen activator inhibitor-1. Knockdown of either protein inhibited the ability of conditioned media derived from MSC paracrine factor stimulated macrophages to induce endothelial cell differentiation both in vitro and in vivo.
[American Journal of Physiology-Cell Physiology]
Sun, H., Pratt, R. E., Hodgkinson, C. P., & Dzau, V. J. (2020). Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00516.2019 Cite
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Mesenchymal Stem Cells-Derived Mitochondria Transplantation Mitigates I/R-Induced Injury, Abolishes I/R-Induced Apoptosis, and Restores Motor Function in Acute Ischemia Stroke Rat Model

Investigators report that the mitochondrial transplantation ameliorated the reperfusion/ischemia-induced damages as reflected by declined blood creatine phosphokinase level, abolished apoptosis, decreased astroglyosis and microglia activation, reduced infarct size, and improved motor function.
[Brain Research Bulletin]
Pourmohammadi-Bejarpasi, Z., Roushandeh, A. M., Saberi, A., Rostami, M. K., Toosi, S. M. R., Jahanian-Najafabadi, A., Tomita, K., Kuwahara, Y., Sato, T., & Roudkenar, M. H. (2020). Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model. Brain Research Bulletin, 165, 70–80. https://doi.org/10.1016/j.brainresbull.2020.09.018 Cite
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Efficacy of Allogeneic Cord Blood Platelet Gel on Wounds of Dystrophic Epidermolysis Bullosa Patients after Pseudosyndactyly Surgery

The authors investigated the therapeutic effects of allogeneic platelet gel prepared from umbilical cord blood in a group of children diagnosed with dystrophic epidermolysis bullosa eligible for surgical correction of pseudosyndactyly in the hand.
[Wound Repair and Regeneration]
Torkamaniha, E., Amirkhani, M. A., Dahmardehei, M., Rebulla, P., Piccin, A., Hortamani, S., Heidari‐Kharaji, M., Mansouri, P., Hamidieh, A. A., & Nilforoushzadeh, M. A. (n.d.). Efficacy of Allogeneic Cord Blood Platelet Gel on Wounds of Dystrophic Epidermolysis Bullosa Patients after Pseudosyndactyly Surgery. Wound Repair and Regeneration, n/a(n/a). https://doi.org/10.1111/wrr.12865 Cite
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Cellular Immunotherapies in Pre-Clinical Large Animal Models of Transplantation

Investigators highlight the contributions of large animal models to the development and fine-tuning of hematopoietic cell transplant and additional cellular therapies to improve organ transplantation outcomes.
[Biology of Blood and Marrow Transplantation]
Matar, A. J., Crepeau, R. L., & Duran-Struuck, R. (2020). Cellular Immunotherapies in Pre-Clinical Large Animal Models of Transplantation. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.09.032 Cite
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Nanographene Oxide-Calcium Phosphate to Inhibit Staphylococcus aureus Infection and Support Stem Cells for Bone Tissue Engineering

Investigators developed an injectable and mechanically strong calcium phosphate bone cement‐chitosan paste containing graphene oxide and investigated the inhibition of Staphylococcus aureus infection and the promotion of human umbilical cord MSCs for bone regeneration.
[Journal of Tissue Engineering and Regenerative Medicine]
Wu, S., Lei, L., Zhang, H., Liu, J., Weir, M. D., Schneider, A., Zhao, L., Liu, J., & Xu, H. H. K. (n.d.). Nanographene oxide-calcium phosphate to inhibit Staphylococcus aureus infection and support stem cells for bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/10.1002/term.3139 Cite
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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Scientists identified a constitutive mechanism of resistance to PARP inhibitor (PARPi). They report that the bone marrow microenvironment facilitates DNA double-strand break repair activity in leukemia cells to protect them against PARPi-mediated synthetic lethality.
[Cell Reports]
Le, B. V., Podszywalow-Bartnicka, P., Maifrede, S., Sullivan-Reed, K., Nieborowska-Skorska, M., Golovine, K., Yao, J.-C., Nejati, R., Cai, K. Q., Caruso, L. B., Swatler, J., Dabrowski, M., Lian, Z., Valent, P., Paietta, E. M., Levine, R. L., Fernandez, H. F., Tallman, M. S., Litzow, M. R., … Skorski, T. (2020). TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. Cell Reports, 33(1). https://doi.org/10.1016/j.celrep.2020.108221 Cite
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Tankyrase Inhibitor XAV-939 Enhances Osteoblastogenesis and Mineralization of Human Skeletal (Mesenchymal) Stem Cells

Researchers investigated the effect of Tankyrase inhibition in osteoblast differentiation of human skeletal MSCs.
[Scientific Reports]
Almasoud, N., Binhamdan, S., Younis, G., Alaskar, H., Alotaibi, A., Manikandan, M., Alfayez, M., Kassem, M., & AlMuraikhi, N. (2020). Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Scientific Reports, 10(1), 16746. https://doi.org/10.1038/s41598-020-73439-9 Cite
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Cynata Stem Cells Test Positive for Heart Attack Repair

Cynata Therapeutics has produced trial results confirming the initial success of its Cymerus MSCs in restoring cardiac function following a heart attack.
[The West Australian]
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H3.3G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumour of Bone

Investigators showed that H3.3K36me3 loss on mutant H3.3 altered the deposition of the repressive H3K27me3 mark from intergenic to genic regions, beyond areas of H3.3 deposition. This promoted redistribution of other chromatin marks and aberrant transcription, altering cell fate in mesenchymal progenitors and hindering differentiation.
[Cancer Discovery]
Khazaei, S., Jay, N. D., Deshmukh, S., Hendrikse, L. D., Jawhar, W., Chen, C. C., Mikael, L. G., Faury, D., Marchione, D. M., Lanoix, J., Bonneil, E., Ishii, T., Jain, S. U., Rossokhata, K., Sihota, T. S., Eveleigh, R., Lisi, V., Harutyunyan, A. S., Jung, S., … Jabado, N. (2020). H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0461 Cite
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Exosomes Derived from CircAkap7-Modified Adipose-Derived Mesenchymal Stem Cells Protect against Cerebral Ischemic Injury

Researchers explored whether exosomes derived from circAkap7-modified adipose-derived MSCs have therapeutic effects on cerebral ischemic injury.
[Frontiers in Cell and Developmental Biology]
Xu, L., Ji, H., Jiang, Y., Cai, L., Lai, X., Wu, F., Hu, R., Yang, X., Bao, H., & Jiang, M. (2020). Exosomes Derived From CircAkap7-Modified Adipose-Derived Mesenchymal Stem Cells Protect Against Cerebral Ischemic Injury. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.569977 Cite
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