Mesenchymal Stem Cell–Based Therapy as a New Approach for the Treatment of Systemic Sclerosis

The authors overview the current knowledge regarding the therapeutic efficacy of MSCs in systemic sclerosis (SSc), focusing on progresses reported in preclinical and clinical studies using MSCs, as well as challenges and future directions of MSC transplantation as a treatment option for patients with SSc.
[Clinical Reviews in Allergy & Immunology]
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Immunomodulatory Effects of Mesenchymal Stem Cells in Peripheral Nerve Injury

Scientists summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following peripheral nerve injuries with a focus on the immunosuppressive role of MSCs.
[Stem Cell Research & Therapy]
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Brazilian Health Regulatory Agency (ANVISA) Authorizes Sorrento Phase II Clinical Trial of COVI-MSC in COVID-19 Patients with Persistent Pulmonary Compromise after Recovery (Long-Hauler)

Sorrento Therapeutics, Inc. announced receipt of clearance from ANVISA to proceed with a Phase IIa randomized, placebo-controlled study of intravenous allogeneic adipose-derived MSC to treat post COVID-19 “long haul” pulmonary compromise.
[Sorrento Therapeutics, Inc.]
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Nanoparticles Functionalized with Stem Cell Secretome and CXCR4-Overexpressing Endothelial Membrane for Targeted Osteoporosis Therapy

Researchers fabricated nanoparticles (NPs) using polylactic-co-glycolic acid loaded with the secretome (Sec) from MSCs to form MSC-Sec NPs.
[Journal of Nanobiotechnology]
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NAP1L2 Drives Mesenchymal Stem Cell Senescence and Suppresses Osteogenic Differentiation

The authors screened the gene expression profiles of human bone marrow MSCs (BMSCs) from young and old donors and identified that elevation of the nucleosome assembly protein 1-like 2 (NAP1L2) expression was correlated with BMSC senescence and impaired osteogenesis.
[Aging Cell]
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Endometrial Stromal Cell Ferroptosis Promotes Angiogenesis in Endometriosis

Scientists revealed that endometrial stromal cell ferroptosis in the ovarian endometrioma may have triggered cytokine secretion and promoted angiogenesis of adjacent lesions via paracrine actions to drive the development of endometriosis.
[Cell Death Discovery]
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A Randomized Controlled Trial of Stem Cell Injection for Tendon Tear

Scientists performed a randomized, controlled study to investigate the effects of mesenchymal stem cell injection for treating partial tears in the supraspinatus tendon.
[Scientific Reports]
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Human Amniotic Mesenchymal Stem Cells Combined with PPCNg Facilitate Injured Endometrial Regeneration

The authors investigated the therapeutic effect of human amniotic MSCs combined with polyethylene glycol citrate-co-N-isopropylacrylamide mixed with gelatin (PPCNg) transplantation in promoting the regeneration of injured endometrium.
[Stem Cell Research & Therapy]
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Effect of Lentivirus-Mediated Growth and Differentiation Factor-5 Transfection on Differentiation of Rabbit Nucleus Pulposus Mesenchymal Stem Cells

Researchers investigated the biological and cytological characteristics of rabbit nucleus pulposus MSCs (NPMSCs) and determined the effect of the growth and differentiation factor-5 on the differentiation of rabbit NPMSCs transduced with a lentivirus vector.
[European Journal of Medical Research]
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Upregulation of CD14 in Mesenchymal Stromal Cells Accelerates Lipopolysaccharide-Induced Response and Enhances Antibacterial Properties

Scientists utilized a systems-based approach to compare MSCs from different genetic backgrounds that displayed differences in antibacterial activity.
[iScience]
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Hypoxia-Inducible Factor 1α Induces Osteo/Odontoblast Differentiation of Human Dental Pulp Stem Cells via Wnt/β-Catenin Transcriptional Cofactor BCL9

The authors examined the role of B-cell CLL/lymphoma 9 (BCL9), which is downstream of hypoxia-inducible factor 1α and a Wnt/β-catenin transcriptional cofactor, in the osteo/odontoblastic differentiation of human dental pulp stem cells under hypoxic conditions.
[Scientific Reports]
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