Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment

Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.
[Stem Cells and Development]
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Novel TCR-like CAR-T Cells to Target an HLA*0201 Restricted Epitope from the Cancer-Testis Antigen SSX2 Display Strong Activity against Acute Myeloid Leukemia

Researchers developed a T cell receptor-like antibody that binds Synovial Sarcoma X breakpoint 2 (SSX2) peptide 41-49 in the context of HLA-A*-0201.
[Molecular Therapy-Methods & Clinical Development]
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Adaptations in Hippo-Yap Signaling and Myofibroblast Fate Underlie Scar-Free Ear Appendage Wound Healing in Spiny Mice

Investigators found that following traumatic injury to ear pinnae, myofibroblasts appeared rapidly in both Acomys and mouse yet persisted only in mouse.
[Developmental Cell]
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Improved Differentiation of hESC-Derived Pancreatic Progenitors by Using Human Fetal Pancreatic Mesenchymal Cells in a Micro‐Scalable Three-Dimensional Co-Culture System

The impact of 3D co-culture of human fetal pancreatic-derived mesenchymal cells with human embryonic stem cell-derived pancreatic progenitors development towards endocrine and beta cells was assessed.
[Stem Cell Reviews and Reports]
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Three-Dimensional Culture Method Enhances the Therapeutic Efficacies of Tonsil-Derived Mesenchymal Stem Cells in Murine Chronic Colitis Model

The authors evaluated enhanced therapeutic effects of tonsil-derived mesenchymal stem cells on a murine colitis model using 3D culture method.
[Scientific Reports]
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PTEN Regulates Proliferation and Osteogenesis of Dental Pulp Cells and Adipogenesis of Human Adipose-Derived Stem Cells

Genetic variant was identified with exome sequencing. The human dental pulp cells isolated from a patient with Cowden syndrome were investigated for their proliferation, osteogenesis, adipogenesis, and gene expression compared with controls.
[Oral Diseases]
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Circulating Cytokines Present in Multiple Myeloma Patients Inhibit the Osteoblastic Differentiation of Adipose Stem Cells

Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.
[Leukemia]
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Osteogenic and Angiogenic Profiles of the Palatal Process of the Maxilla and the Palatal Process of the Palatine Bone

The authors found that the period in which avascular mesenchymal condensation became a vascularized bone structure corresponded to embryonic day 14.5 to embyronic day 16.5 in the hard palate.
[Journal of Anatomy]
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Intravenous Injection of Mesenchymal Stem Cell Spheroids Improves the Pulmonary Delivery and Prolongs In Vivo Survival

Murine adipose-derived MSC line m17.ASC was cultured in agarose-based microwell plates to obtain size-controlled m17.ASC spheroids of an average diameter and cell number of approximately 170 μm and 1100 cells/spheroid, respectively.
[Biotechnology Journal]
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KU Researcher Wins $1.25 Million Award to Investigate the Vital Role of Sex Hormones in Tissue Repair

A researcher at the University of Kansas has earned a five-year, $1.25 million Maximizing Investigators’ Research Award from the National Institutes of Health to study how estrogen interacts with the body at the level of the cell microenvironment.
[Universityof Kansas (News-Medical.Net)]
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Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing

The authors summarize current knowledge on how stem cell-derived nanovesicles regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process.
[Stem Cells International]
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