COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Dose and Duration of Interferon γ Pre-Licensing Interact with Donor Characteristics to Influence the Expression and Function of Indoleamine-2,3-Dioxygenase in Mesenchymal Stromal Cells

Scientists found that across three human MSC donors, MSCs increased their expression of indoleamine-2,3-dioxygenase in response to both increased dose of IFNγ and duration of pre-licensing.
[Journal of the Royal Society interface]
Boyt, D. T., Boland, L. K., Burand, A. J., Brown, A. J., & Ankrum, J. A. (2020). Dose and duration of interferon γ pre-licensing interact with donor characteristics to influence the expression and function of indoleamine-2,3-dioxygenase in mesenchymal stromal cells. Journal of The Royal Society Interface, 17(167), 20190815. https://doi.org/10.1098/rsif.2019.0815 Cite
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Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39−CD73 Signaling Pathway

Gingiva derived-mesenchymal stem cells limited the development of autoantibodies as well as proteinuria, decreases the frequency of plasma cells and lupus nephritis histopathological scores by directly suppressing B cells activation, proliferation and differentiation.
[Journal of Autoimmunity]
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Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells

Investigators report the ability of a scalable hollow fiber bioreactor to effectively maintain ideal mesenchymal stem cell function as a single population while also being able to impart an immunoregulatory effect when cultured in tandem with an inflamed lymphocyte population.
[Scientific Reports]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Ultragenyx and Kyowa Kirin Announce US FDA Approval of Crysvita® (Burosumab) for the Treatment of Tumor-Induced Osteomalacia (TIO)

Ultragenyx Pharmaceutical, Inc. and Kyowa Kirin Co., Ltd. announced that the FDA has approved Crysvita® for the treatment of fibroblast growth factor 23-related hypophosphatemia in tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors that cannot be curatively resected or localized in adults and pediatric patients two years of age and older.
[Ultragenyx Pharmaceutical, Inc.]
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Runx2 Regulates Mouse Tooth Root Development via Activation of WNT Inhibitor Notum

Investigators provided in vivo evidence that Runx2 played a crucial role in tooth root development and in regulating the differentiation of root progenitor cells.
[Journal of Bone and Mineral Research]
Wen, Q., Jing, J., Han, X., Feng, J., Yuan, Y., Ma, Y., Chen, S., Ho, T.-V., & Chai, Y. (n.d.). Runx2 regulates mouse tooth root development via activation of WNT inhibitor Notum. Journal of Bone and Mineral Research, n/a(n/a). https://doi.org/10.1002/jbmr.4120 Cite
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Berberine Mediates Root Remodeling in an Immature Tooth with Apical Periodontitis by Regulating Stem Cells from Apical Papilla Differentiation

Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity, mineralization ability, and gene expression of osteogenic makers.
[International Journal of Oral Science]
Cui, Y., Xie, J., Fu, Y., Li, C., Zheng, L., Huang, D., Zhou, C., Sun, J., & Zhou, X. (2020). Berberine mediates root remodeling in an immature tooth with apical periodontitis by regulating stem cells from apical papilla differentiation. International Journal of Oral Science, 12(1), 1–10. https://doi.org/10.1038/s41368-020-0085-7 Cite
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Induction of ASC Pyroptosis Requires Gasdermin D or Caspase-1/11-Dependent Mediators and IFNβ from Pyroptotic Macrophages

Scientists found that LPS, flagellin, dsDNA, nigericin, or LPS combined with nigericin could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells.
[Cell Death & Disease]
Zhang, C., Zhao, C., Chen, X., Tao, R., Wang, S., Meng, G., Liu, X., Shao, C., & Su, X. (2020). Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages. Cell Death & Disease, 11(6), 1–13. https://doi.org/10.1038/s41419-020-2664-0 Cite
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Geriatric Fragility Fractures are Associated with a Human Skeletal Stem Cell Defect

Functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity.
[Aging Cell]
Ambrosi, T. H., Goodnough, L. H., Steininger, H. M., Hoover, M. Y., Kim, E., Koepke, L. S., Marecic, O., Zhao, L., Seita, J., Bishop, J. A., Gardner, M. J., & Chan, C. K. F. (n.d.). Geriatric fragility fractures are associated with a human skeletal stem cell defect. Aging Cell, n/a(n/a), e13164. https://doi.org/10.1111/acel.13164 Cite
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