Chemical Systems Biology Reveals Mechanisms of Glucocorticoid Receptor Signaling

Researchers used a chemical systems biology approach, ligand class analysis, to examine ligands designed to modulate glucocorticoid receptor activity through distinct structural mechanisms.
[Nature Chemical Biology]

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No Difference in Survival after HLA Mismatched versus HLA Matched Allogeneic Stem Cell Transplantation in Ewing Sarcoma Patients with Advanced Disease

Patients with advanced Ewing sarcoma (AES) carry a poor prognosis. Retrospectively, researchers analyzed 66 AES patients treated with allogeneic stem cell transplantation receiving HLA-mismatched versus HLA-matched grafts.
[Bone Marrow Transplantation]

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Extracellular Vesicles Deposit PCNA to Rejuvenate Aged Bone Marrow-Derived Mesenchymal Stem Cells and Slow Age-Related Degeneration

Scientists demonstrated that neonatal umbilical cord (UC) is a source of extracellular vesicles (EVs) derived from MSCs. These UC-produced MSC-EVs contain abundant anti-aging signals and rejuvenate senescing adult bone marrow-derived MSCs.
[Science Translational Medicine]

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Role of Lysophosphatidic Acid and Its Receptors in Health and Disease: Novel Therapeutic Strategies

The authors review the literature about the differential signaling of lysophosphatidic acid through its specific receptors, which makes this lipid a versatile signaling molecule.
[Signal Transduction and Targeted Therapy]

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A Flow Cytometric Assay for the Quantification of MSC Lysis by Peripheral Blood Mononucleated Cells

The authors describe a flow cytometric assay based on differential immunostaining of target and effector cells where BM MSC are enumerated with fluorospheres to determine the loss of target cells after co-culture with PB MNC.
[Heliyon]

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Genomic Variations in Patients with Myelodysplastic Syndrome and Karyotypes without Numerical or Structural Changes

30.8% (28/91) of the selected genes showed altered expression and 2/3 of these genes showed positive regulation when compared to public data on gene expression in mesenchymal stromal cells of bone marrow tissue in primary myelodysplastic syndrome.
[Scientific Reports]

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PDGFRb+ Mesenchymal Cells, but not NG2+ Mural Cells, Contribute to Cardiac Fat

Scientists performed lineage tracing studies by using various genetic models and find that cardiac mesenchymal cells contribute to cardiac adipocytes in postnatal development and adult homeostasis.
[Cell Reports]

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Cell-Based Strategies for IVD Repair: Clinical Progress and Translational Obstacles

Investigators discuss current approaches to disc regeneration, with a particular focus on cell-based therapeutic strategies, including ongoing challenges, and attempts to provide a framework to interpret current data and guide future investigational studies.
[Nature Reviews Rheumatology]

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Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts

The differentiation of Wharton jelly (WJ)-MSCs into Schwann cell-like cells was determined by analyzing Schwann cell-specific markers. The secretion of neurotrophic factors was assessed by the Neuro Discovery antibody array.
[Tissue Engineering and Regenerative Medicine]
Choi, S. J., Park, S. Y., Shin, Y. H., Heo, S.-H., Kim, K.-H., Lee, H. I., & Kim, J. K. (2021). Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-020-00329-6 Cite
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Mesenchymal Stem Cell-Derived Interleukin-28 Drives the Selection of Apoptosis Resistant Bone Metastatic Prostate Cancer

Scientists report mesenchymal stem cell-derived interleukin-28 (IL-28) triggered prostate cancer cell apoptosis via IL-28 receptor alpha STAT1 signaling.
[Nature Communications]
McGuire, J. J., Frieling, J. S., Lo, C. H., Li, T., Muhammad, A., Lawrence, H. R., Lawrence, N. J., Cook, L. M., & Lynch, C. C. (2021). Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer. Nature Communications, 12(1), 723. https://doi.org/10.1038/s41467-021-20962-6 Cite
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Single Cell Sequencing Reveals Endothelial Plasticity with Transient Mesenchymal Activation after Myocardial Infarction

The authors explored the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing.
[Nature Communications]
Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E.-M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S.-I., … Dimmeler, S. (2021). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nature Communications, 12(1), 681. https://doi.org/10.1038/s41467-021-20905-1 Cite
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