Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
[Cell Biology and Toxicology]
Song, Y., Wang, B., Zhu, X., Hu, J., Sun, J., Xuan, J., & Ge, Z. (2020). Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09530-8 Cite
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Autism-Associated SHANK3 Mutations Impair Maturation of Neuromuscular Junctions and Striated Muscles

Investigators used a combination of patient-derived human iPSCs, Shank3Δ11(−/−) mice, and Phelan-McDermid syndrome muscle biopsies from patients of different ages to analyze the role of SHANK3 on motor unit development.
[Science Translational Medicine]
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Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

In Dog and Human, the authors described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]

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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Cell Type Specific Adhesion to Surfaces Functionalised by Amine Plasma Polymers

The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.
[Scientific Reports]
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miR-195 Enhances Cardiomyogenic Differentiation of the Proepicardium/Septum Transversum by Smurf1 and Foxp1 Modulation

Investigators provide a comprehensive characterization of the developmental expression profile of multiple microRNAs during epicardial development in chicken. They identified that miR-125, miR-146, miR-195 and miR-223 selectively enhanced cardiomyogenesis both in the proepicardium/ST explants as well as in the embryonic epicardium, a Smurf1- and Foxp1-driven process.
[Scientific Reports]
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Human Umbilical Cord Blood-Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Overexpression of divalent metal transporter 1 (DMT1) promoted H/R-induced myocardial cell ferroptosis, while knockdown of DMT1 significantly inhibited the ferroptosis.
[Cell Biology and Toxicology]
Song, Y., Wang, B., Zhu, X., Hu, J., Sun, J., Xuan, J., & Ge, Z. (2020). Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09530-8 Cite
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Selective Induction of Human Autonomic Neurons Enables Precise Control of Cardiomyocyte Beating

Neurons were individually induced, facilitating the regulation of the beating rates of hiPSC-derived cardiomyocytes in an antagonistic manner.
[Scientific Reports]
Takayama, Y., Kushige, H., Akagi, Y., Suzuki, Y., Kumagai, Y., & Kida, Y. S. (2020). Selective Induction of Human Autonomic Neurons Enables Precise Control of Cardiomyocyte Beating. Scientific Reports, 10(1), 9464. https://doi.org/10.1038/s41598-020-66303-3 Cite
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Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-Muscle Myosin II Assembly and Function in Migrating Cells

In cells, phosphorylation of Y155, or its phospho-mimetic mutation, prevented the interaction of regulatory light chain with the myosin heavy chain to form functional non-muscle myosin II units.
[Current Biology]
Aguilar-Cuenca, R., Llorente-González, C., Chapman, J. R., Talayero, V. C., Garrido-Casado, M., Delgado-Arévalo, C., Millán-Salanova, M., Shabanowitz, J., Hunt, D. F., Sellers, J. R., Heissler, S. M., & Vicente-Manzanares, M. (2020). Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells. Current Biology, 0(0). https://doi.org/10.1016/j.cub.2020.04.057 Cite
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Generation of Myogenic Progenitor Cell-Derived Smooth Muscle Cells for Sphincter Regeneration

Cultivation of myogenic progenitor cells in smooth muscle differentiation medium significantly increased the fraction of alpha smooth muscle actin and smoothelin-positive cells, while leaving the number of desmin-positive cells unchanged.
[Stem Cell Research & Therapy]
Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved June 15, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01749-w Cite
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Kv1.3 Blockade Inhibits Proliferation of Vascular Smooth Muscle Cells In Vitro and Intimal Hyperplasia In Vivo

In vitro phenotypic modulation of vascular smooth muscle cells (VSMC) was associated to an increased functional expression of Kv1.3 channels, and only selective Kv1.3 channel blockers were able to inhibit porcine VSMC proliferation.
[Translational Research]
Bobi, J., Garabito, M., Solanes, N., Cidad, P., Ramos-Pérez, V., Ponce, A., Rigol, M., Freixa, X., Pérez-Martínez, C., Prado, A. P. de, Fernández-Vázquez, F., Sabaté, M., Borrós, S., López-López, J. R., Pérez-García, M. T., & Roqué, M. (2020). Kv1.3 blockade Inhibits Proliferation of Vascular Smooth Muscle Cells In Vitro and Intimal Hyperplasia In Vivo. Translational Research, 0(0). https://doi.org/10.1016/j.trsl.2020.06.002 Cite
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IGFBP6 Regulates Vascular Smooth Muscle Cell Proliferation and Morphology via Cyclin E-CDK2

Knocking down insulin‐like growth factor binding protein 6 in vascular smooth muscle cells significantly attenuated cell proliferation and induced the S phase arrest during the cell cycle.
[Journal of Cellular Physiology]
IGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E–CDK2 - Wang - - Journal of Cellular Physiology - Wiley Online Library. (n.d.). Retrieved June 12, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29762 Cite
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