Clonally Expanding Smooth Muscle Cells Promote Atherosclerosis by Escaping Efferocytosis and Activating the Complement Cascade

Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]
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Human MuStem Cell Grafting Into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

Researchers described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]
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Yin Yang 1 Is Required for PHD Finger Protein 20-Mediated Myogenic Differentiation In Vitro and In Vivo

Investigators found that protein and mRNA expression levels of PHF20 were decreased during myogenic differentiation in C2C12 cells.
[Cell Death & Differentiation]
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Dissecting Myogenin-Mediated Retinoid X Receptor Signaling in Myogenic Differentiation

The authors found that rexinoid x receptor signaling associated with the distribution of myogenin at poised enhancers and a distinct E-box motif. They also found an association of myogenin with rexinoid-responsive gene expression and identified an epigenetic signature related to histone acetyltransferase p300.
[Communications Biology]
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Intracellular Calcium Leak in Heart Failure and Atrial Fibrillation: A Unifying Mechanism and Therapeutic Target

The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]
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The Importance of the ZBED6-IGF2 Axis for Metabolic Regulation in Mouse Myoblast Cells

Scientists showed a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6−/− myoblasts.
[FASEB Journal]
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Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix

Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research]
Wu Chi-Chung, Jeratsch Sylvia, Graumann Johannes, & Stainier Didier. (n.d.). Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316303 Cite
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Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification

In vitro cultures of synthetic vascular smooth muscle cells (VSMCs) showed decreased expression of contractile markers CNN1, αSMA and SM22α and an increase in synthetic marker S100A4 compared to contractile VSMCs.
[Circulation Research]
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Searching for Novel Hydrogen Sulfide Donors: The Vascular Effects of Two Thiourea Derivatives

In human aortic smooth muscle cells, diphenylthiourea caused membrane hyperpolarization, mediated by activation of KATP and Kv7 potassium channels.
[Pharmacological Research]
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LncRNA LBX2-AS1 Facilitates Abdominal Aortic Aneurysm through miR-4685-5p/LBX2 Feedback Loop

The effects of dysregulated ladybird homeobox 2 antisense RNA 1 or ladybird homeobox 2 on vascular smooth muscle cell biological processes were surveyed via cell counting kit-8, methyl thiazolyl tetrazolium, terminal-deoxynucleoitidyl transferase mediated nick end labeling and caspase-3 activity assays.
[Biomedicine & PharmacoTherapy]
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FOXO3a-Mediated Long Non-Coding RNA LINC00261 Resists Cardiomyocyte Hypoxia/Reoxygenation Injury via Targeting miR23b-3p/NRF2 Axis

The expression of LINC00261 was significantly down-regulated in myocardial tissues and H9C2 cells. Overexpression of LINC00261 improved cardiac function and reduced myocardium apoptosis.
[Journal of Cellular and Molecular Medicine]
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