The authors focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other β-cardiac myosin mutations. Human induced pluripotent stem cell–cardiomyocytes with the P710R mutation produced significantly increased force compared with isogenic control cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Scientists employed the sex-mismatched murine aortic graft model of graft arteriopathy in wild type and inducible smooth muscle-specific Tet2 knockout mice, and in vitro studies in vascular smooth muscle cells (VSMCs) to assess the role of TET2 in VSMC responses to IFNу, a cytokine elaborated by T cells that drives coronary allograft vasculopathy progression.
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Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.
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Using type 2 diabetic db/db mice in vivo and isolated sinoatrial node (SAN) myocytes, scientists investigated whether blunted parasympathetic nervous system (PNS) effects on HR in type 2 diabetes mellitus were related to impaired responsiveness of the SAN to PNS agonists.
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The authors investigated the involvement of TAM receptor kinases Mer and Axl in the muscle regeneration process by studying the muscle repair following cardiotoxin-induced injury in Mer−/− mice.In vitro inhibition of TAM kinase signaling in C2C12 myoblasts resulted in decreased viability and in impaired myotube growth.
[Cell Death & Disease]
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Researchers used asthma model bronchial smooth muscle cells to measure the biological behaviors of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.
[Journal of Translational Medicine]
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Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.
[Cellular and Molecular Life Sciences]
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Heartseed, Inc., a biotechnology company developing iPSC-derived cardiomyocytes for heart failure, announced it has raised approx. $37 Million at Series C round. These funds will accelerate the initiation of a global clinical trial of HS-001, an allogeneic iPSC-derived, highly purified ventricular cardiomyocyte spheroids for heart failure.
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Scientists summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports]
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Researchers showed that targeted ablation of the histone chaperone HIRA in myogenic cells led to extensive transcriptional modifications, consistent with a role in maintaining skeletal muscle cellular identity.
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The authors investigated the role of late sodium current conductance in arrhythmias using adult primary cardiomyocytes and tissues from donor hearts.
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