Researchers showed that Pbk, a serine/threonine protein kinase, was essential for high fat diet‐induced beta cell proliferation in vivo using a Pbk kinase deficiency knock‐in mouse model.
[EMBO Molecular Medicine]
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Ma, J., Xing, B., Cao, Y., He, X., Bennett, K. E., Tong, C., An, C., Hojnacki, T., Feng, Z., Deng, S., Ling, S., Xie, G., Wu, Y., Ren, Y., Yu, M., Katona, B. W., Li, H., Naji, A., & Hua, X. (2021). Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation. EMBO Molecular Medicine, n/a(n/a), e13524. https://doi.org/10.15252/emmm.202013524 Cite
Scientists discuss the discoveries that have led to the current understanding of how insulin promotes glucose uptake in muscle.
Scientists highlighted tissue-specific differences between skeletal and cardiac muscles in their reliance on core autophagy proteins and unique roles for ULK1-ULK2 and RB1CC1 among these proteins in the development of TARDBP+ pathology.
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Investigators demonstrated that the Sphingosine kinase-1 silencing in neonatal mouse cardiomyocytes facilitated their postnatal maturation in both physiological and stress conditions.
[International Journal of Molecular Sciences]
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Researchers demonstrated that exosomes from differentiating CTX0E03 cells could reduce infarct size in mice. In an in vitro assay, these exosomes delayed cardiomyocyte mitochondrial permeability transition pore opening, which was responsible for cardiomyocyte death after reperfusion.
[Journal of Cellular and Molecular Medicine]
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The authors show that the splicing factor IK contributes to normal skeletal muscle development in vivo and myogenic differentiation in vitro.
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Scientists developed a mass cytometry panel to investigate the dynamic nature of muscle regeneration at a single-cell level. Using the panel, they identified early changes in the proteome of stressed satellite and niche cells.
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Researchers showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhanced vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering]
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Scientists investigated whether and how Piezo1 regulate the intracellular calcium homeostasis in human pulmonary arterial smooth muscle cells under normal and pulmonary arterial hypertension conditions.
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Liao Jing, Lu Wenju, Chen Yuqin, Duan Xin, Zhang Chenting, Luo Xiaoyun, Lin Ziying, Chen Jiyuan, Liu Shiyun, Yan Han, Chen Yilin, Feng Huazhuo, Zhou Dansha, Chen Xu, Zhang Zizhou, Yang Qifeng, Liu Xinyi, Tang Haiyang, Li Jing, … Wang Jian. (n.d.). Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients. Hypertension, 0(0), HYPERTENSIONAHA.120.16629. https://doi.org/10.1161/HYPERTENSIONAHA.120.16629 Cite
Investigators demonstrated that sphingosine-1-phosphate (S1P) promoted the activation of STAT3 through sphingosine-1-phosphate receptor 2, and subsequently upregulated the expression of the microRNA miR-135b, which further reduced the expression of E3 ubiquitin ligase β-transduction repeat-containing protein and led to a reduction in YAP ubiquitinated degradation in pulmonary artery smooth muscle cell.
[Journal of Biological Chemistry]
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Scientists describe the developmental origin of smooth muscle cells within different tissues by comparing their specification and differentiation with other organs, including the cardiovascular, respiratory and intestinal systems. They also discuss the instructive roles of smooth muscle in the development of such organs through signaling and mechanical feedback mechanisms.
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