Hypertrophic Cardiomyopathy β-Cardiac Myosin Mutation (P710R) Leads to Hypercontractility by Disrupting Super Relaxed State

The authors focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other β-cardiac myosin mutations. Human induced pluripotent stem cell–cardiomyocytes with the P710R mutation produced significantly increased force compared with isogenic control cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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TET2 Protects against VSMC Apoptosis and Intimal Thickening in Transplant Vasculopathy

Scientists employed the sex-mismatched murine aortic graft model of graft arteriopathy in wild type and inducible smooth muscle-specific Tet2 knockout mice, and in vitro studies in vascular smooth muscle cells (VSMCs) to assess the role of TET2 in VSMC responses to IFNу, a cytokine elaborated by T cells that drives coronary allograft vasculopathy progression.
[Circulation]
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Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury

Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.
[Circulation Research]
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Impaired Regulation of Heart Rate and Sinoatrial Node Function by the Parasympathetic Nervous System in Type 2 Diabetic Mice

Using type 2 diabetic db/db mice in vivo and isolated sinoatrial node (SAN) myocytes, scientists investigated whether blunted parasympathetic nervous system (PNS) effects on HR in type 2 diabetes mellitus were related to impaired responsiveness of the SAN to PNS agonists.
[Scientific Reports]
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TAM Kinase Signaling Is Indispensable for Proper Skeletal Muscle Regeneration in Mice

The authors investigated the involvement of TAM receptor kinases Mer and Axl in the muscle regeneration process by studying the muscle repair following cardiotoxin-induced injury in Mer−/− mice.In vitro inhibition of TAM kinase signaling in C2C12 myoblasts resulted in decreased viability and in impaired myotube growth.
[Cell Death & Disease]
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HDAC4 Induces the Development of Asthma by Increasing Slug-Upregulated CXCL12 Expression through KLF5 Deacetylation

Researchers used asthma model bronchial smooth muscle cells to measure the biological behaviors of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.
[Journal of Translational Medicine]
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The Multifaceted View of Heart Problem in Duchenne Muscular Dystrophy

Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.
[Cellular and Molecular Life Sciences]
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Heartseed Raises $37 Million in Series C Funding to Accelerate Development of iPSC-Derived Stem Cell Therapy for Heart Failure

Heartseed, Inc., a biotechnology company developing iPSC-derived cardiomyocytes for heart failure, announced it has raised approx. $37 Million at Series C round. These funds will accelerate the initiation of a global clinical trial of HS-001, an allogeneic iPSC-derived, highly purified ventricular cardiomyocyte spheroids for heart failure.
[Heartseed, Inc.]
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Mesenchymal Stromal Cell-Derived Exosomes in Cardiac Regeneration and Repair

Scientists summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports]
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Hira Stabilizes Skeletal Muscle Lineage Identity

Researchers showed that targeted ablation of the histone chaperone HIRA in myogenic cells led to extensive transcriptional modifications, consistent with a role in maintaining skeletal muscle cellular identity.
[Nature Communications]
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Arrhythmogenic and Antiarrhythmic Actions of Late Sustained Sodium Current in the Adult Human Heart

The authors investigated the role of late sodium current conductance in arrhythmias using adult primary cardiomyocytes and tissues from donor hearts.
[Scientific Reports]
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