Scientists challenged network modeling with time-resolved proteome, transcriptome and methylome measurements in iPSC-derived human 3D cardiac microtissues to elucidate adverse mechanisms of anthracycline cardiotoxicity measured with four different drugs.
6630899 WDR9GGUV items 1 apa default asc 1
Selevsek, N., Caiment, F., Nudischer, R., Gmuender, H., Agarkova, I., Atkinson, F. L., Bachmann, I., Baier, V., Barel, G., Bauer, C., Boerno, S., Bosc, N., Clayton, O., Cordes, H., Deeb, S., Gotta, S., Guye, P., Hersey, A., Hunter, F. M. I., … Kleinjans, J. (2020). Network integration and modelling of dynamic drug responses at multi-omics levels. Communications Biology, 3(1), 1–15. https://doi.org/10.1038/s42003-020-01302-8 Cite
Dp71ab, but not Dp71, was found to be a molecular enhancer of myoblast proliferation and transfection with Dp71ab may generate a high yield of stem cells for Duchenne muscular dystrophy treatment.
6630899 CCXSYUT4 items 1 apa default asc 1
Researchers showed that hydrogen peroxide (H2O2), produced extracellularly, was necessary for the hypertrophic response of isolated cardiac myocytes and that aquaporin-1 facilitated the transmembrane transport of H2O2 through its water pore, resulting in activation of oxidant-sensitive kinases in cardiac myocytes.
[Science Translational Medicine]
6630899 KID52UHV items 1 apa default asc 1
Montiel, V., Bella, R., Michel, L. Y. M., Esfahani, H., Mulder, D. D., Robinson, E. L., Deglasse, J.-P., Tiburcy, M., Chow, P. H., Jonas, J.-C., Gilon, P., Steinhorn, B., Michel, T., Beauloye, C., Bertrand, L., Farah, C., Zotti, F. D., Debaix, H., Bouzin, C., … Balligand, J.-L. (2020). Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Science Translational Medicine, 12(564). https://doi.org/10.1126/scitranslmed.aay2176 Cite
Scientists analyzed the applicability of a hydrojet-based method to deliver footprint-free iPSC-derived cardiomyocytes into the myocardium.
6630899 JI8U763Z items 1 apa default asc 1
Weber, M., Fech, A., Jäger, L., Steinle, H., Bühler, L., Perl, R. M., Martirosian, P., Mehling, R., Sonanini, D., Aicher, W. K., Nikolaou, K., Schlensak, C., Enderle, M. D., Wendel, H. P., Linzenbold, W., & Avci-Adali, M. (2020). Hydrojet-based delivery of footprint-free iPSC-derived cardiomyocytes into porcine myocardium. Scientific Reports, 10(1), 16787. https://doi.org/10.1038/s41598-020-73693-x Cite
Scientists investigated the role of Type 2 inositol 1,4,5-trisphosphate receptor (IP3R2) in the differentiation of human embryonic stem cells (hESCs) to cardiomyocytes and in the hESC-derived cardiomyocytes.
[Acta Pharmacologica Sinica]
1254621 F9E7WIRH items 1 apa default asc 1
The authors used both genetic and pharmacological approaches to investigate the effect of targeting myostatin/activin A signaling in mice that were sent to the International Space Station.
[Proceedings of the National Academy of Sciences of the United States of America]
1254621 22X2TB2P items 1 apa default asc 1
Lee, S.-J., Lehar, A., Meir, J. U., Koch, C., Morgan, A., Warren, L. E., Rydzik, R., Youngstrom, D. W., Chandok, H., George, J., Gogain, J., Michaud, M., Stoklasek, T. A., Liu, Y., & Germain-Lee, E. L. (2020). Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight. Proceedings of the National Academy of Sciences, 117(38), 23942–23951. https://doi.org/10.1073/pnas.2014716117 Cite
To test the hypothesis that the disruption caused by tetrachlorodibenzo-p-dioxin in the heart results from changes in DNA methylation and gene expression patterns of cardiomyocytes, researchers established a stable mouse embryonic stem cell line expressing a puromycin resistance selectable marker under control of the cardiomyocyte-specific Nkx2-5 promoter.
1254621 5L7ADKCW items 1 apa default asc 1
Both induced pluripotent stem cells derived from a Marfan syndrome (MFS)-patient and the line with the corrected fibrillin-1 mutation were differentiated to cardiomyocytes. Several functional analyses were performed on this model to study MFS related cardiomyopathy.
1254621 GNY4VUD8 items 1 apa default asc 1
Aalders, J., Léger, L., Van der Meeren, L., Van den Vreken, N., Skirtach, A. G., Sinha, S., De Backer, J., & van Hengel, J. (2020). Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome. Scientific Reports, 10(1), 16756. https://doi.org/10.1038/s41598-020-73802-w Cite
Researchers showed that a PIX protein has an important function in muscle. From a genetic screen in C. elegans, they found that pix-1 was required for the assembly of integrin adhesion complexes at borders between muscle cells, and was required for locomotion of the animal.
1254621 KYSBLC6W items 1 apa default asc 1
Moody, J. C., Qadota, H., Reedy, A. R., Okafor, C. D., Shanmugan, N., Matsunaga, Y., Christian, C. J., Ortlund, E. A., & Benian, G. M. (2020). The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. Nature Communications, 11(1), 5010. https://doi.org/10.1038/s41467-020-18852-4 Cite
Scientists investigated the role of mmu-miR-324-5p in the differentiation of C2C12 myoblasts and lipid droplet deposition in myotubes for future targeted therapies.
[Molecular Therapy-Nucleic Acids]
1254621 U748XKGH items 1 apa default asc 1
Liu, Y., Wang, J., Zhou, X., Cao, H., Zhang, X., Huang, K., Li, X., Yang, G., & Shi, X. (2020). MiR-324-5p inhibits C2C12 myoblasts differentiation and promotes intramuscular lipid deposition through LncDUM and PM20D1, respectively. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.037 Cite
Using three complementary mouse models of carotid artery injury, researchers demonstrated that both tamoxifen and estradiol accelerated endothelial healing, but only tamoxifen required the presence of the underlying medial smooth muscle cells.
1254621 AWTSAMTE items 1 apa default asc 1
Zahreddine Rana, Davezac Morgane, Smirnova Natalia F, Buscato Mélissa, Lhuillier Emeline, Lupieri Adrien, Solinhac Romain, Vinel Alexia, Vessieres Emilie, Henrion Daniel, Renault Marie-Ange, Gadeau Alain-Pierre, Flouriot Gilles, Lenfant Francoise, Laffargue Muriel, Metivier Raphael, Arnal Jean-Francois, & Fontaine Coralie. (n.d.). Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cell. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317062 Cite