Baxter Announces US Approval and Launch of Ready-to-Use Cardiovascular Medicine Norepinephrine in Premix Formulation

Baxter International, Inc. announced the US FDA approval and commercial launch of premix Norepinephrine Bitartrate in 5% Dextrose Injection.
[Baxter International Inc.]
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Cell Proliferation Fate Mapping Reveals Regional Cardiomyocyte Cell-Cycle Activity in Subendocardial Muscle of Left Ventricle

Scientists found that the majority of cycling cardiomyocytes were positioned in the subendocardial muscle of the left ventricle, especially in the papillary muscles
[Nature Communications]
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The circRNA CNEACR Regulates Necroptosis of Cardiomyocytes through Foxa2 Suppression

Scientists found that the level of mmu_circ_000338, a cardiac- necroptosis-associated circRNA, was reduced in hypoxia-reoxygenation exposed cardiomyocytes and ischemia-reperfusion-injured mice hearts.
[Cell Death & Disease]
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Human Cardiac Stem Cells Rejuvenated by Modulating Autophagy with MHY-1685 Enhance the Therapeutic Potential for Cardiac Repair

Scientists employed MHY-1685, a novel mammalian target of rapamycin inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation.
[Experimental and Molecular Medicine]
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In Vitro CSC-Derived Cardiomyocytes Exhibit the Typical microRNA-mRNA Blueprint of Endogenous Cardiomyocytes

The down-regulation of cell cycle genes and the up-regulation of the mature myofilament genes in cardiomyocytes in vitro (iCMs) reached intermediate levels between those of fetal and neonatal cardiomyocytes. Cardiomyo-miRs were up-regulated in iCMs.
[Communications Biology]
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Endothelial Cell-Derived Pro-fibrotic Factors Increase TGF-β1 Expression by Smooth Muscle Cells in Response to Cycles of Hypoxia-Hyperoxia

Researchers investigated the mechanisms by which pathological changes in the microvasculature direct fibrosis in the context of ischemia-reperfusion.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
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USP10 Exacerbates Neointima Formation by Stabilizing Skp2 Protein in Vascular Smooth Muscle Cells

USP10 expression was detected in mouse arteries and increased after carotid ligation. In vitro data showed that USP10 deficiency reduced proliferation and migration of rat thoracic aorta smooth muscle cells (A7r5) and human aortic smooth muscle cells (HASMCs).
[Journal of Biological Chemistry]
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The Proliferation and Migration of Atherosclerosis-Related HVSMCs Were Inhibited by Downregulation of lncRNA XIST via Regulation of the miR-761/BMP9 Axis

Scientists found that lncRNA XIST was related to the abnormal proliferation and migration of human vascular smooth muscle cells (HVSMCs), and thus, the mechanism by which XIST regulated HVSMCs was further investigated.
[Kaohsiung Journal of Medical Sciences]
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Circ-LAMP2 Regulates Aortic Smooth Muscle Cell Proliferation and Apoptosis in Thoracic Aortic Aneurysm via Modulation of Autophagy and NF-κB Pathway

The apoptosis of smooth muscle cells is a major feature of thoracic aortic aneurysm. Scientists investigated the roles of circ_0091434 in human aortic smooth muscle cells.
[Human Pathology]
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Master Regulators of Skeletal Muscle Lineage Development and Pluripotent Stem Cells Differentiation

The expression of genes MYF5, MRF4, MYOD is activated by muscle progenitors throughout development, in several waves of myogenic differentiation, constituting the embryonic, fetal and postnatal phases of muscle growth.
[Cell Regeneration]
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Increased β-Adrenergic Stimulation Augments Vascular Smooth Muscle Cell Calcification via PKA/CREB Signalling

Scientists explored the effects of β2-adrenergic stimulation by isoproterenol on vascular smooth muscle cells (VSMC) calcification. Experiments were performed in primary human aortic VSMCs treated with isoproterenol during control or high phosphate conditions.
[Pflugers Archiv-European Journal of Physiology]
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