Upregulation of TGF-β Type II Receptor in High Glucose-Induced Vascular Smooth Muscle Cells

Scientists investigated the effects of high-glucose conditions on TGF-β type II receptor expression levels, cell viability, and migration rate in vascular smooth muscle cells.
[Molecular Biology Reports]
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Lycium barbarum Polysaccharide Antagonizes Cardiomyocyte Apoptosis by Inhibiting the Upregulation of GRK2 Induced by I/R Injury, and Salvage Mitochondrial Fission/Fusion Imbalance and AKT/eNOS Signaling

Scientists found that Lycium barbarum polysaccharide limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress.
[Cellular Signalling]
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Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression during Human Cardiomyocyte Differentiation

During a dynamic process such as cellular differentiation, the overall cell type composition of a tissue (or an in vitro culture) and the gene regulatory profile of each cell can both experience significant changes over time.
[PLoS Genetics]
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Nampt Activator P7C3 Ameliorates Diabetes and Improves Skeletal Muscle Function Modulating Cell Metabolism and Lipid Mediators

Researchers assessed the functional, morphometric, biochemical, and molecular effects of P7C3 treatment in skeletal muscle of type 2 diabetic (db/db) mice.
[Journal of Cachexia Sarcopenia and Muscle]
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Venus Concept Receives FDA 510(k) Clearance of Venus BlissMAX for Non-invasive Lipolysis of the Abdomen and Flanks, Cellulite Reduction and Muscle Conditioning

Venus Concept Inc. announced that it has received 510(k) clearance from the US FDA to market the Venus BlissMAX device in the United States.
[Venus Concept Inc. (GlobeNewswire, Inc.)]
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Enrichment of the Exocytosis Protein STX4 in Skeletal Muscle Remediates Peripheral Insulin Resistance and Alters Mitochondrial Dynamics via Drp1

Researchers showed that transgenic skeletal muscle-specific STX4 enrichment in mice reverses established insulin resistance and improves mitochondrial function in the context of diabetogenic stress.
[Nature Communications]
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Phosphodiesterase 4D Promotes Angiotensin II-Induced Hypertension in Mice via Smooth Muscle Cell Contraction

Researchers revealed that phosphodiesterase (PDE) 4D expression was upregulated in the aortas of experimental hypertension induced by angiotensin II.
[Communications Biology]
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The MFF-SIRT1/3 Axis, Regulated by miR-340-5p, Restores Mitochondrial Homeostasis of Hypoxia-Induced Pulmonary Artery Smooth Muscle Cells

Pulmonary artery smooth muscle cells were cultured in hypoxia condition for constructing a pulmonary arterial hypertension model in vitro. The expression of genes and proteins were determined by qRT-PCR and western bolt assays.
[Laboratory Investigation]
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Overexpression of the SARS-CoV-2 Receptor Angiotensin Converting Enzyme 2 in Cardiomyocytes of Failing Hearts

Scientists examined the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure.
[Scientific Reports]
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Ca2+ Leak through Ryanodine Receptor 1 Regulates Thermogenesis in Resting Skeletal Muscle

By inhibiting a subpopulation of ryanodine receptor 1 (RyR1)s in a single-fiber preparation via targeted delivery of ryanodine through transverse tubules, scientists achieved in-preparation isolation of RyR1 Ca2+ leak.
[Proceedings of the National Academy of Sciences of the United States of America]
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