Investigators examined whether oxidative and glycolytic muscle fibers responded differentially to exogenous anabolic androgenic steroids by comparing morphological and histological changes between the oxidative anterior latissimus dorsi and glycolytic pectoralis major fibers in adult avian muscles.
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Investigators showed that expression of Homeobox-A (Hox-A) cluster genes accompanied with DNA hypermethylation of the Hox-A locus was robustly maintained in both somite-derived muscles and their associated satellite cells in adult mice, which recapitulated their embryonic origin.
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Researchers investigated the positional relationship between the microtubule nucleating sites and the Golgi apparatus in C2C12 myotubes and in primary cultured mouse skeletal myotubes.
[Histochemistry and Cell Biology]
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The authors suggested that the disease mechanism of childhood cardiomyopathy was due to accumulation of human BAG3P209L and mouse Bag3, causing sequestering of components of the protein quality control system and autophagy machinery leading to sarcomere disruption.
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Scientists showed that CD38 deficiency in lymphocytes led to lack of protection against Ang II-induced vascular remodeling, suggesting that the effects of CD38 on Ang II-induced vascular remodeling may have relied primarily on vascular smooth muscle cells, not lymphocytes.
[Signal Transduction and Targeted Therapy]
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The authors survey recent observations that are shedding more light on the nature of the interaction between circadian rhythms and the vascular system with implications for blood vessel disease.
[Current Opinion in Pharmacology]
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With a view to team science, the programme ZonMw Open Competition is specifically aimed at innovative and groundbreaking combinations of two or more research groups.
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Scientists used quantitative mass spectrometry to characterize intrinsic changes in the muscle stem cell (MuSC) proteome and remodeling of the MuSC niche during aging.
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Scientists present different mechanisms by which T cells contribute to inflammaging and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota.
[Nature Reviews Immunology]
The authors discussed the potential of “organ-on-a-chip” systems to study regenerative therapies with focus on three distinct organ systems: cardiac, respiratory, and hematopoietic.
[Cell Stem Cell]
Researchers investigated the dominant rule determining synchronization of beating intervals of cardiomyocytes after the clustering of mouse primary and human embryonic stem cell-derived cardiomyocytes.
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