Differential Response of Oxidative and Glycolytic Skeletal Muscle Fibers to Mesterolone

Investigators examined whether oxidative and glycolytic muscle fibers responded differentially to exogenous anabolic androgenic steroids by comparing morphological and histological changes between the oxidative anterior latissimus dorsi and glycolytic pectoralis major fibers in adult avian muscles.
[Scientific Reports]
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Hoxa10 Mediates Positional Memory to Govern Stem Cell Function in Adult Skeletal Muscle

Investigators showed that expression of Homeobox-A (Hox-A) cluster genes accompanied with DNA hypermethylation of the Hox-A locus was robustly maintained in both somite-derived muscles and their associated satellite cells in adult mice, which recapitulated their embryonic origin.
[Science Advances]
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The Golgi Apparatus Is the Main Microtubule-Organizing Center in Differentiating Skeletal Muscle Cells

Researchers investigated the positional relationship between the microtubule nucleating sites and the Golgi apparatus in C2C12 myotubes and in primary cultured mouse skeletal myotubes.
[Histochemistry and Cell Biology]
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Overexpression of Human BAG3P209L in Mice Causes Restrictive Cardiomyopathy

The authors suggested that the disease mechanism of childhood cardiomyopathy was due to accumulation of human BAG3P209L and mouse Bag3, causing sequestering of components of the protein quality control system and autophagy machinery leading to sarcomere disruption.
[Nature Communications]
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CD38 Deficiency Alleviates Ang II-Induced Vascular Remodeling by Inhibiting Small Extracellular Vesicle-Mediated Vascular Smooth Muscle Cell Senescence in Mice

Scientists showed that CD38 deficiency in lymphocytes led to lack of protection against Ang II-induced vascular remodeling, suggesting that the effects of CD38 on Ang II-induced vascular remodeling may have relied primarily on vascular smooth muscle cells, not lymphocytes.
[Signal Transduction and Targeted Therapy]
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Review: Circadian Clocks and Rhythms in the Vascular Tree

The authors survey recent observations that are shedding more light on the nature of the interaction between circadian rhythms and the vascular system with implications for blood vessel disease.
[Current Opinion in Pharmacology]
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Team Science for Groundbreaking Fundamental Research Receives Boost of 12.5 Million Euros

With a view to team science, the programme ZonMw Open Competition is specifically aimed at innovative and groundbreaking combinations of two or more research groups.
[ZonMw]
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Extensive Remodeling of the Extracellular Matrix during Aging Contributes to Age-Dependent Impairments of Muscle Stem Cell Functionality

Scientists used quantitative mass spectrometry to characterize intrinsic changes in the muscle stem cell (MuSC) proteome and remodeling of the MuSC niche during aging.
[Cell Reports]
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The Role of T Cells in Age-Related Diseases

Scientists present different mechanisms by which T cells contribute to inflammaging and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota.
[Nature Reviews Immunology]
Carrasco, E., Gómez de las Heras, M. M., Gabandé-Rodríguez, E., Desdín-Micó, G., Aranda, J. F., & Mittelbrunn, M. (2021). The role of T cells in age-related diseases. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-021-00557-4 Cite
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Harnessing Organs-on-a-Chip to Model Tissue Regeneration

The authors discussed the potential of “organ-on-a-chip” systems to study regenerative therapies with focus on three distinct organ systems: cardiac, respiratory, and hematopoietic.
[Cell Stem Cell]
Tavakol, D. N., Fleischer, S., & Vunjak-Novakovic, G. (2021). Harnessing organs-on-a-chip to model tissue regeneration. Cell Stem Cell, 28(6), 993–1015. https://doi.org/10.1016/j.stem.2021.05.008 Cite
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Emergent Synchronous Beating Behavior in Spontaneous Beating Cardiomyocyte Clusters

Researchers investigated the dominant rule determining synchronization of beating intervals of cardiomyocytes after the clustering of mouse primary and human embryonic stem cell-derived cardiomyocytes.
[Scientific Reports]
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