Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

Understanding biological mechanisms involved in the long-term alcohol exposure-induced cardiotoxicity is pivotal to the discovery of therapeutic strategies. Cardiomyocytes derived from human pluripotent stem cells were treated with clinically relevant doses of ethanol for various durations up to five weeks.
[Stem Cell Reviews and Reports]
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The Actin Depolymerizing Factor, Destrin, Serves as a Negative Feedback Inhibitor of Smooth Muscle Cell Differentiation

Scientists identified several regulatory regions that control DSTN expression including a SMC-selective enhancer that was activated by the MRTF/SRF, Notch/RBPJ, and SMAD transcription factors.
[American Journal of Physiology-Heart and Circulatory Physiology]
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Bioactive Compounds from Artemisia dracunculus L. Activate AMPK Signaling in Skeletal Muscle

Scientists examined PMI-5011 activation of AMP-activated protein kinase (AMPK) signaling using murine C2C12 muscle cell culture and skeletal muscle tissue.
[Biomedicine & Pharmacotherapy]
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Methyltransferase-Like 3 (METTL3) Attenuates Cardiomyocyte Apoptosis with Myocardial Ischemia-Reperfusion (I/R) Injury through miR-25-3p and miR-873-5p

Researchers showed that methyltransferase-like 3 (METTL3) was downregulated in mice ischemia-reperfusion (I/R) myocardial tissues and hypoxic/re-oxygenated (H/R) cardiomyocytes, and upregulation of METTL3 attenuated I/R and H/R-induced cell apoptosis.
[Cell Biology International]
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Cellular and Molecular Modulation of Rotator Cuff Muscle Pathophysiology

Scientists highlight the current understanding of the cellular processes that coordinate muscle regeneration, and the roles of muscle resident cells, including immune cells, fibroadipogenic progenitors, and muscle satellite cells in the pathophysiologic regulation of rotator cuff muscles following injury.
[Journal of Orthopaedic Research]
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Sarepta Therapeutics to Initiate Part B of MOMENTUM Study of SRP-5051 in Patients with Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping Following Positive Interactions with FDA

Sarepta Therapeutics, Inc. announced that following positive interactions with the US FDA, the Company plans to initiate Part B of the MOMENTUM study, in the fourth quarter. MOMENTUM is a global trial investigating the use of SRP-5051, the Company’s next-generation peptide-conjugated phosphorodiamidate morpholino oligomer to treat patients with Duchenne muscular dystrophy who are amenable to exon 51 skipping.
[Sarepta Therapeutics, Inc.]
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Neuronal Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis Is Developmentally Regulated

Scientists used human iPSCs and generated a developmental timeline by differentiating sporadic amyotrophic lateral sclerosis (sALS) iPSCs to neural progenitors and to motor neurons and comparing mitochondrial parameters with familial ALS and control cells at each developmental stage.
[Scientific Reports]
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Role of PDE10A in Vascular Smooth Muscle Cell Hyperplasia and Pathological Vascular Remodeling

Intimal hyperplasia is a common feature of vascular remodeling disorders. Accumulation of synthetic smooth muscle cell (SMC)-like cells is the main underlying cause. Researchers investigated the function of PDE10A in smooth muscle cell proliferation and intimal hyperplasia both in vitro and in vivo.
[Cardiovascular Research]
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Cardiomyocyte microRNA-150 Confers Cardiac Protection and Directly Represses Proapoptotic Small Proline–Rich Protein 1A

Scientists demonstrated that potentially novel conditional cardiomyocyte–specific miR-150 knock out in mice worsened maladaptive cardiac remodeling after myocardial infarction.
[JCI Insight]
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Researchers Receive National Award to Further Study Muscular Dystrophy, Cancer and Heart Failure

Three Virginia Commonwealth University researchers were awarded funding that will support the expansion of their health research and translation of that research into improved care for patients.
[Virginia Commonwealth University]
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Inhibition of MicroRNA-30a Alleviates Vascular Remodeling in Pulmonary Arterial Hypertension

Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.
[Molecular Therapy-Nucleic Acids]
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