Understanding biological mechanisms involved in the long-term alcohol exposure-induced cardiotoxicity is pivotal to the discovery of therapeutic strategies. Cardiomyocytes derived from human pluripotent stem cells were treated with clinically relevant doses of ethanol for various durations up to five weeks.
[Stem Cell Reviews and Reports]
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Scientists identified several regulatory regions that control DSTN expression including a SMC-selective enhancer that was activated by the MRTF/SRF, Notch/RBPJ, and SMAD transcription factors.
[American Journal of Physiology-Heart and Circulatory Physiology]
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Scientists examined PMI-5011 activation of AMP-activated protein kinase (AMPK) signaling using murine C2C12 muscle cell culture and skeletal muscle tissue.
[Biomedicine & Pharmacotherapy]
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Researchers showed that methyltransferase-like 3 (METTL3) was downregulated in mice ischemia-reperfusion (I/R) myocardial tissues and hypoxic/re-oxygenated (H/R) cardiomyocytes, and upregulation of METTL3 attenuated I/R and H/R-induced cell apoptosis.
[Cell Biology International]
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Scientists highlight the current understanding of the cellular processes that coordinate muscle regeneration, and the roles of muscle resident cells, including immune cells, fibroadipogenic progenitors, and muscle satellite cells in the pathophysiologic regulation of rotator cuff muscles following injury.
[Journal of Orthopaedic Research]
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Sarepta Therapeutics, Inc. announced that following positive interactions with the US FDA, the Company plans to initiate Part B of the MOMENTUM study, in the fourth quarter. MOMENTUM is a global trial investigating the use of SRP-5051, the Company’s next-generation peptide-conjugated phosphorodiamidate morpholino oligomer to treat patients with Duchenne muscular dystrophy who are amenable to exon 51 skipping.
[Sarepta Therapeutics, Inc.]
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Scientists used human iPSCs and generated a developmental timeline by differentiating sporadic amyotrophic lateral sclerosis (sALS) iPSCs to neural progenitors and to motor neurons and comparing mitochondrial parameters with familial ALS and control cells at each developmental stage.
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Intimal hyperplasia is a common feature of vascular remodeling disorders. Accumulation of synthetic smooth muscle cell (SMC)-like cells is the main underlying cause. Researchers investigated the function of PDE10A in smooth muscle cell proliferation and intimal hyperplasia both in vitro and in vivo.
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Scientists demonstrated that potentially novel conditional cardiomyocyte–specific miR-150 knock out in mice worsened maladaptive cardiac remodeling after myocardial infarction.
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Three Virginia Commonwealth University researchers were awarded funding that will support the expansion of their health research and translation of that research into improved care for patients.
[Virginia Commonwealth University]
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Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.
[Molecular Therapy-Nucleic Acids]
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