Uremic Toxins Impair Skeletal Muscle Regeneration by Inhibiting Myoblast Proliferation, Reducing Myogenic Differentiation, and Promoting Muscular Fibrosis

This study analyzes the role of uremic toxins in sarcopenia at different stages of chronic kidney disease (CKD), evaluating changes in the muscular regeneration process. Cultured C2C12 cells were incubated with a combination of indoxyl sulphate and p-cresol at high doses or low doses resembling late or early CKD stages, respectively.
[Scientific Reports]
Alcalde-Estévez, E., Sosa, P., Asenjo-Bueno, A., Plaza, P., Olmos, G., Naves-Díaz, M., Rodríguez-Puyol, D., López-Ongil, S., & Ruiz-Torres, M. P. (2021). Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis. Scientific Reports, 11(1), 512. https://doi.org/10.1038/s41598-020-79186-1 Cite
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Endothelial Cells Control Vascular Smooth Muscle Cell Cholesterol Levels by Regulating 24-Dehydrocholesterol Reductase Expression

The authors investigated changes of the vascular smooth muscle cell (VSMC) transcriptome by utilizing 3D human vascular organoids organized as a core of VSMCs enclosed by a monolayer of endothelial cells.
[Experimental Cell Research]
Kohlhaas, J., Jäger, M., Lust, L., De La Torre, C., Hecker, M., & Korff, T. (2021). Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Experimental Cell Research, 112446. https://doi.org/10.1016/j.yexcr.2020.112446 Cite
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Prilenia Announces First Patient Enrolled for Pridopidine Phase II/III Platform Trial for ALS

Prilenia Therapeutics B.V. announced the enrollment of the first participant for treatment with pridopidine in the pivotal HEALEY ALS Platform Trial.
[Prilenia Therapeutics B.V.]
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Pfizer Doses First Participant in Phase III Study for Duchenne Muscular Dystrophy Investigational Gene Therapy

Pfizer Inc. announced that the first participant has been dosed in the Phase III CIFFREO study, which will evaluate the efficacy and safety of investigational gene therapy candidate PF-06939926 in boys with Duchenne muscular dystrophy.
[Pfizer Inc.]
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Lnc-Rps4l-Encoded Peptide RPS4XL Regulates RPS6 Phosphorylation Inhibits the Proliferation of Pulmonary Artery Smooth Muscle Cells Caused by Hypoxia

Researchers hypothesized in this study that an lnc-Rps4l-encoded peptide is involved in hypoxic induced pulmonary artery smooth muscle cells (PASMCs) proliferation. The presence of peptide RPS4XL encoded by lnc-Rps4l in PASMCs under hypoxic conditions were confirmed by bioinformatics, immunofluorescence and immunohistochemistry.
[Molecular Therapy]
Li, Y., Zhang, J., Sun, H., Chen, Y., Li, W., Yu, X., Zhao, X., Zhang, L., Yang, J., Xin, W., Jiang, Y., Wang, G., Shi, W., & Zhu, D. (2021). Lnc-Rps4l-encoded peptide RPS4XL regulates RPS6 phosphorylation inhibits the proliferation of pulmonary artery smooth muscle cells caused by hypoxia. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.01.005 Cite
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ERG1 Plays an Essential Role in Rat Cardiomyocyte Fate Decision by Mediating AKT Signaling

Using the rat embryonic stem cells model, investigators showed that ERG1 was crucial in cardiomyocyte lineage commitment via interactions with integrin β1.
[Stem Cells]
Wang, D., Liu, C., Liu, H., Meng, Y., Lin, F., Gu, Y., Wang, H., Shang, M., Tong, C., Sachinidis, A., Ying, Q., Li, L., & Peng, L. (n.d.). ERG1 Plays an Essential Role in Rat Cardiomyocyte Fate Decision by Mediating AKT Signaling. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3328 Cite
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Molecular Expression and Functional Features of Kv7 Channels in Human Prostate Smooth Muscle

In human prostatic smooth muscle cells, KCNQ4, KCNQ5, and KCNE4 isoforms were predominantly expressed, while KCNQ1, KCNQ5, and KCNE3 isoforms were the most abundantly expressed in human prostatic tissues.
[Andrology]
Choi, J., Han, D. H., Chae, M. R., Sung, H. H., Kang, S. J., Shin, J., & Lee, S. W. (n.d.). Molecular expression and functional features of Kv7 channels in human prostate smooth muscle. Andrology, n/a(n/a). https://doi.org/https://doi.org/10.1111/andr.12967 Cite
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Effect of Hydrogen Peroxide Concentration on the Maintenance and Differentiation of Cultured Skeletal Muscle Cells

Researchers studied the effects of hydrogen peroxide (H2O2) on the differentiation and maintenance of C2C12 myoblasts. The effects of H2O2 were evaluated by cell viability, total protein concentration, the relative amount of muscle-related proteins, sarcomere structure, and active tension generation.
[Journal of Bioscience and Bioengineering]
Fujita, H., Mae, K., Nagatani, H., Horie, M., & Nagamori, E. (2021). Effect of hydrogen peroxide concentration on the maintenance and differentiation of cultured skeletal muscle cells. Journal of Bioscience and Bioengineering. https://doi.org/10.1016/j.jbiosc.2020.12.010 Cite
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PDGFRα Mediated Survival of Myofibroblasts Inhibit Satellite Cell Proliferation during Aberrant Regeneration of Lacerated Skeletal Muscle

Investigators showed that the decline in myofibroblasts’ number through inhibition of PDGFRα signaling consequently promoted proliferation of the SCs and exhibited improved skeletal muscle remodeling.
[Scientific Reports]
Thooyamani, A. S., & Mukhopadhyay, A. (2021). PDGFRα mediated survival of myofibroblasts inhibit satellite cell proliferation during aberrant regeneration of lacerated skeletal muscle. Scientific Reports, 11(1), 63. https://doi.org/10.1038/s41598-020-79771-4 Cite
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Hypoxia-Induced Amniotic Fluid Stem Cell Secretome Augments Cardiomyocyte Proliferation and Enhances Cardioprotective Effects under Hypoxic-Ischemic Conditions

Researchers hypothesized that modulation of oxygen conditions during uman amniotic fluid stem cell generation enriches soluble bioactive factors and confers enhanced regenerative and cardioprotective effects on cardiovascular cells.
[Scientific Reports]
Kukumberg, M., Phermthai, T., Wichitwiengrat, S., Wang, X., Arjunan, S., Chong, S. Y., Fong, C.-Y., Wang, J.-W., Rufaihah, A. J., & Mattar, C. N. Z. (2021). Hypoxia-induced amniotic fluid stem cell secretome augments cardiomyocyte proliferation and enhances cardioprotective effects under hypoxic-ischemic conditions. Scientific Reports, 11(1), 163. https://doi.org/10.1038/s41598-020-80326-w Cite
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Mirroring Action Potentials: Label‐Free, Accurate, and Noninvasive Electrophysiological Recordings of Human‐Derived Cardiomyocytes

A new approach for recording intracellular signals of outstanding quality and with noninvasiveness is introduced. By taking profit of the concept of mirror charge in classical electrodynamics, the new proposed device transduces cell ionic currents into mirror charges in a microfluidic chamber, thus realizing a virtual mirror cell.
[Advanced Materials]
Barbaglia, A., Dipalo, M., Melle, G., Iachetta, G., Deleye, L., Hubarevich, A., Toma, A., Tantussi, F., & Angelis, F. D. (n.d.). Mirroring Action Potentials: Label-Free, Accurate, and Noninvasive Electrophysiological Recordings of Human-Derived Cardiomyocytes. Advanced Materials, n/a(n/a), 2004234. https://doi.org/https://doi.org/10.1002/adma.202004234 Cite
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