Scientists examined the sub-cellular compartmentalization of Nox isoforms in lipid rafts/caveolae and assessed the role of these microdomains in vascular smooth muscle cell reactive oxygen species production and pro-contractile and growth signaling.
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Researchers report that carboxyl terminus of Hsc70-interacting protein-mediated protein turnover is markedly post-translationally enhanced by direct protein kinase G phosphorylation at S20.
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Thomas Longden, PhD, assistant professor in the Department of Physiology at the University of Maryland School of Medicine, has received the National Institutes of Health (NIH) Director’s New Innovator Award. The award provides $2.3 million to support an “exceptionally creative early career investigator” as part of the High-Risk, High-Reward Research Program of the NIH Common Fund.
[University of Maryland Baltimore]
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All-trans retinoic acid (ATRA) could repress the PDGF-bb-induced excessive proliferation and migration of human umbilical vein smooth muscle cells, which was mediated by Rb-E2F dependent cell cycle inhibition.
[Cardiovascular Drugs and Therapy]
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Yu, Y., Wang, Y., Fei, X., Song, Z., Xie, F., Yang, F., Liu, X., Xu, Z., & Wang, G. (2020). All-Trans Retinoic Acid Prevented Vein Grafts Stenosis by Inhibiting Rb-E2F Mediated Cell Cycle Progression and KLF5-RARα Interaction in Human Vein Smooth Muscle Cells. Cardiovascular Drugs and Therapy. https://doi.org/10.1007/s10557-020-07089-4 Cite
To define molecular mechanisms for the damaging cardiac outflow tract defects caused by GATA6 variants, scientists studied transcriptional and epigenetic responses to GATA6 loss of function and missense variants during cardiomyocyte differentiation of isogenic human iPSCs.
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Sharma, A., Wasson, L. K., Willcox, J. A., Morton, S. U., Gorham, J. M., DeLaughter, D. M., Neyazi, M., Schmid, M., Agarwal, R., Jang, M. Y., Toepfer, C. N., Ward, T., Kim, Y., Pereira, A. C., DePalma, S. R., Tai, A., Kim, S., Conner, D., Bernstein, D., … Seidman, C. E. (2020). GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm. ELife, 9, e53278. https://doi.org/10.7554/eLife.53278 Cite
Using immortalized patient-derived muscle cells and local intramuscular injections in the FLExDUX4 FSHD mouse model, scientists showed that their designed 2’-MOE gapmers significantly reduced DUX4 transcript levels in vitro and in vivo, respectively.
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Lim, K. R. Q., Bittel, A., Maruyama, R., Echigoya, Y., Nguyen, Q., Huang, Y., Dzierlega, K., Zhang, A., Chen, Y.-W., & Yokota, T. (2020). DUX4 transcript knockdown with antisense 2’-O-methoxyethyl gapmers for the treatment of facioscapulohumeral muscular dystrophy. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.10.010 Cite
Revance Therapeutics, Inc. announced positive topline results from its ASPEN-1 Phase III randomized, double-blind, placebo-controlled, parallel group clinical trial for its investigational drug candidate DaxibotulinumtoxinA for injection for the treatment of cervical dystonia, a chronic and debilitating neurologic condition affecting the muscles of the neck.
[Revance Therapeutics, Inc.]
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The US FDA have granted a Rare Pediatric Disease designation to The Italfarmaco Group’s proprietary histone deacetylase inhibitor, Givinostat, for the treatment of Duchenne Muscular Dystrophy, which allows an expedited review process for new treatment modalities. The company also announced the completion of patient enrollment in the EPIDYS Phase III trial.
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The authors consider the biomolecular role for the vitamin D/Vitamin D receptor (VDR) axis in myogenesis, while also exploring global evidence for genomic and non‐genomic mechanisms of action for 1,25(OH)2D3/VDR.
[Cell Biochemistry and Function]
Progesterone supplementation enhanced cardiomyocyte proliferation in a progesterone receptor‐dependent manner. Progesterone up‐regulated YAP expression and knockdown of YAP by small interfering RNA reduced progesterone‐mediated cardiomyocyte proliferative effect.
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Lan, C., Cao, N., Chen, C., Qu, S., Fan, C., Luo, H., Zeng, A., Yu, C., Xue, Y., Ren, H., Li, L., Wang, H., Jose, P. A., Xu, Z., & Zeng, C. (n.d.). Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair. Cell Proliferation, n/a(n/a), e12910. https://doi.org/10.1111/cpr.12910 Cite
Scientists determined the physiological functions of Activin A, Notch and Sonic Hedgehog signaling in the proliferation of mouse C2C12 myoblasts and to explore their interactions.
[Molecular and Cellular Endocrinology]
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