Role of Smooth Muscle Activation in the Static and Dynamic Mechanical Characterization of Human Aortas

Scientists illustrated the importance of vascular smooth muscle activation for the static and dynamic mechanical response of human aortas.
[Proceedings of the National Academy of Sciences of the United States of America]
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Serum-Free Cultures of C2C12 Cells Show Different Muscle Phenotypes Which Can Be Estimated by Metabolic Profiling

Researchers performed metabolic profiling of the C2C12 myoblasts and myotubes in serum-free mediums and compared it with conventional serum supplementation culture.
[Scientific Reports]
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Dynamics of Skeletal Muscle-Resident Stem Cells during Myogenesis in Fibrodysplasia Ossificans Progressiva

Researchers demonstrated that while two resident stem cell populations, muscle stem cells (MuSCs) and fibro/adipogenic progenitors, have similar proliferation rates after injury, the differentiation potential of mutant MuSCs was compromised.
[NPJ Regenerative Medicine]
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2-Benzyllawsone Protects against Polymicrobial Sepsis and Vascular Hyporeactivity in Swiss Albino Mice

Evaluation of 2-benzyllawsone against vascular hyporeactivity, hypotension, and sepsis-related inflammation and infection was carried out in the cecal ligation and puncture model in Swiss albino mice and aortic smooth muscle cells in vitro.
[European Journal of Pharmacology]
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LncRNA-XIST Promotes Proliferation and Migration in Ox-LDL Stimulated Vascular Smooth Muscle Cells through miR-539-5p/SPP1 Axis

Researchers discovered the possible role and mechanism of long coding RNA XIST in oxidized low-density lipoprotein- stimulated vascular smooth muscle cells, which could further help evalute its possible a role in the progression of atherosclerosis.
[Oxidative Medicine and Cellular Longevity]
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A20 (TNFAIP3) Alleviates Viral Myocarditis through ADAR1/miR-1a-3p-Dependent Regulation

A20 was underexpressed and miR-1a-3p was overexpressed in the myocardium of VMC mice as well as in Coxsackie virus B3-infected cardiomyocytes.
[BMC Cardiovascular Disorders]
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Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium

Researchers measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies and sera of nonischemic PVB19-positive and PVB19-negative dilated cardiomyopathy patients.
[Advances in Experimental Medicine and Biology]
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Sarepta Therapeutics’ Gene Therapy SRP-9001 Shows Statistically Significant Functional Improvements Compared to Pre-Specified Matched External Control in Part II of Study SRP-9001-102 for the Treatment of Duchenne Muscular Dystrophy

Sarepta Therapeutics, Inc. announced topline results from Part II of Study SRP-9001-102, an ongoing, randomized, double-blind, placebo-controlled clinical trial to evaluate the safety, efficacy and tolerability of a single dose of SRP-9001 in 41 patients with Duchenne muscular dystrophy.
[Sarepta Therapeutics]
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Roles and Potential Clinical Implications of Tissue Transglutaminase in Cardiovascular Diseases

Scientists summarize recent advances in tissue transglutaminase and discuss its role and mechanisms in the progression of various cardiovascular disease and its potential as a diagnostic and therapeutic target.
[Pharmacological Research]
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MyoD Is a 3D Genome Structure Organizer for Muscle Cell Identity

Investigators showed that MyoD functioned as a “genome organizer” that specified 3D genome architecture unique to muscle cell development, and that H3K27ac was insufficient for the establishment of MyoD-induced chromatin loops in muscle cells.
[Nature Communications]
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Clenbuterol Exerts Antidiabetic Activity through Metabolic Reprogramming of Skeletal Muscle Cells

To elucidate the underlying cellular and molecular mechanisms, researchers chronically treated wild-type mice and several newly developed mutant mouse strains with clenbuterol, a selective β2-adrenergic receptor agonist.
[Nature Communications]
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