Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-Muscle Myosin II Assembly and Function in Migrating Cells

In cells, phosphorylation of Y155, or its phospho-mimetic mutation, prevented the interaction of regulatory light chain with the myosin heavy chain to form functional non-muscle myosin II units.
[Current Biology]
Aguilar-Cuenca, R., Llorente-González, C., Chapman, J. R., Talayero, V. C., Garrido-Casado, M., Delgado-Arévalo, C., Millán-Salanova, M., Shabanowitz, J., Hunt, D. F., Sellers, J. R., Heissler, S. M., & Vicente-Manzanares, M. (2020). Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells. Current Biology, 0(0). https://doi.org/10.1016/j.cub.2020.04.057 Cite
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Generation of Myogenic Progenitor Cell-Derived Smooth Muscle Cells for Sphincter Regeneration

Cultivation of myogenic progenitor cells in smooth muscle differentiation medium significantly increased the fraction of alpha smooth muscle actin and smoothelin-positive cells, while leaving the number of desmin-positive cells unchanged.
[Stem Cell Research & Therapy]
Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved June 15, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01749-w Cite
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Kv1.3 Blockade Inhibits Proliferation of Vascular Smooth Muscle Cells In Vitro and Intimal Hyperplasia In Vivo

In vitro phenotypic modulation of vascular smooth muscle cells (VSMC) was associated to an increased functional expression of Kv1.3 channels, and only selective Kv1.3 channel blockers were able to inhibit porcine VSMC proliferation.
[Translational Research]
Bobi, J., Garabito, M., Solanes, N., Cidad, P., Ramos-Pérez, V., Ponce, A., Rigol, M., Freixa, X., Pérez-Martínez, C., Prado, A. P. de, Fernández-Vázquez, F., Sabaté, M., Borrós, S., López-López, J. R., Pérez-García, M. T., & Roqué, M. (2020). Kv1.3 blockade Inhibits Proliferation of Vascular Smooth Muscle Cells In Vitro and Intimal Hyperplasia In Vivo. Translational Research, 0(0). https://doi.org/10.1016/j.trsl.2020.06.002 Cite
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IGFBP6 Regulates Vascular Smooth Muscle Cell Proliferation and Morphology via Cyclin E-CDK2

Knocking down insulinā€like growth factor binding protein 6 in vascular smooth muscle cells significantly attenuated cell proliferation and induced the S phase arrest during the cell cycle.
[Journal of Cellular Physiology]
IGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E–CDK2 - Wang - - Journal of Cellular Physiology - Wiley Online Library. (n.d.). Retrieved June 12, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29762 Cite
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Hepatoma-Derived Growth Factor Enhances Osteoblastic Transformation of Rat Aortic Vascular Smooth Muscle Cells In Vitro

Recombinant hepatoma-derived growth factor (HDGF) treatment enhanced vascular smooth muscle cells growth and motility. Treatment of osteogenic medium increased expression of not only HDGF but also osteoblastic markers.
[Life Sciences]
Cheng, C.-I., Chang, H.-R., Tai, M.-H., Chou, M.-H., Chen, G.-T., Chen, P.-H., & Kao, Y.-H. (2020). Hepatoma-derived growth factor enhances osteoblastic transformation of rat aortic vascular smooth muscle cells in vitro. Life Sciences, 117964. https://doi.org/10.1016/j.lfs.2020.117964 Cite
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Advanced Glycation End-Products Suppress Autophagy by AMPK/mTOR Signaling Pathway to Promote Vascular Calcification

Pretreatment with autophagy activator rapamycin and AMPK activator AICAR both upregulated the autophagy level and downregulated the effects of advanced glycation end-products on osteoblastic differentiation of vascular smooth muscle cells.
[Molecular and Cellular Biochemistry]
Liu, Y., Li, J., Han, Y., Chen, Y., Liu, L., Lang, J., Yang, C., Luo, H., & Ning, J. (2020). Advanced glycation end-products suppress autophagy by AMPK/mTOR signaling pathway to promote vascular calcification. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03769-9 Cite
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The Role of B Cells in Heart Failure and Implications for Future Immunomodulatory Treatment Strategies

B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells.
[ESC Heart Failure]
García‐Rivas, G., Castillo, E. C., Gonzalez‐Gil, A. M., Maravillas‐Montero, J. L., Brunck, M., Torres‐Quintanilla, A., Elizondo‐Montemayor, L., & Torre‐Amione, G. (n.d.). The role of B cells in heart failure and implications for future immunomodulatory treatment strategies. ESC Heart Failure, n/a(n/a). https://doi.org/10.1002/ehf2.12744 Cite
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Sarepta Therapeutics Announces Positive Expression and Functional Data From the SRP-9003 Gene Therapy Trial to Treat Limb-Girdle Muscular Dystrophy Type 2E

Sarepta Therapeutics announced positive results from a study of SRP-9003, its investigational gene therapy for limb-girdle muscular dystrophy Type 2E.
[Sarepta Therapeutics]
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Acellular Bioscaffolds Redirect Cardiac Fibroblasts and Promote Functional Tissue Repair in Rodents and Humans with Myocardial Injury

Scientists used acellular biologic extracellular matrix scaffolds (bioscaffolds) to stimulate pathways of muscle repair and restore tissue function. They showed that acellular bioscaffolds with bioinductive properties can redirect cardiac fibroblasts to rebuild microvascular networks and avoid tissue fibrosis.
[Scientific Reports]
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Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Scientists showed that tri-cellular combinations of human induced pluripotent stem cells (iPSC)-derived cardiomyocytes, cardiac fibroblasts, and cardiac endothelial cells enhanced maturation in easily constructed, scaffold-free, three-dimensional microtissues.
[Cell Stem Cell]
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