Searching for Novel Hydrogen Sulfide Donors: The Vascular Effects of Two Thiourea Derivatives

In human aortic smooth muscle cells, diphenylthiourea caused membrane hyperpolarization, mediated by activation of KATP and Kv7 potassium channels.
[Pharmacological Research]
Citi, V., Martelli, A., Bucci, M., Piragine, E., Testai, L., Vellecco, V., Cirino, G., & Calderone, V. (2020). Searching for novel hydrogen sulfide donors: the vascular effects of two thiourea derivatives. Pharmacological Research, 105039. https://doi.org/10.1016/j.phrs.2020.105039 Cite
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LncRNA LBX2-AS1 Facilitates Abdominal Aortic Aneurysm through miR-4685-5p/LBX2 Feedback Loop

The effects of dysregulated ladybird homeobox 2 antisense RNA 1 or ladybird homeobox 2 on vascular smooth muscle cell biological processes were surveyed via cell counting kit-8, methyl thiazolyl tetrazolium, terminal-deoxynucleoitidyl transferase mediated nick end labeling and caspase-3 activity assays.
[Biomedicine & PharmacoTherapy]
Li, H., Zhang, H., Wang, G., Chen, Z., & Pan, Y. (2020). LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through miR-4685-5p/LBX2 feedback loop. Biomedicine & Pharmacotherapy, 129, 109904. https://doi.org/10.1016/j.biopha.2020.109904 Cite
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FOXO3a-Mediated Long Non-Coding RNA LINC00261 Resists Cardiomyocyte Hypoxia/Reoxygenation Injury via Targeting miR23b-3p/NRF2 Axis

The expression of LINC00261 was significantly down-regulated in myocardial tissues and H9C2 cells. Overexpression of LINC00261 improved cardiac function and reduced myocardium apoptosis.
[Journal of Cellular and Molecular Medicine]
Zhang, R., Li, Y., Liu, X., Qin, S., Guo, B., Chang, L., Huang, L., & Liu, S. (n.d.). FOXO3a-mediated long non-coding RNA LINC00261 resists cardiomyocyte hypoxia/reoxygenation injury via targeting miR23b-3p/NRF2 axis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15292 Cite
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Sarepta Therapeutics and Selecta Biosciences Enter Into Research License and Option Agreement for Selecta’s ImmTOR Immune Tolerance Platform in Neuromuscular Diseases

Sarepta Therapeutics, Inc. and Selecta Biosciences, Inc. announced that they have entered into a research license and option agreement granting Sarepta an option to license the rights to develop and commercialize Selecta’s immune tolerance platform for use in Duchenne muscular dystrophy and certain limb-girdle muscular dystrophies.
[Sarepta Therapeutics, Inc.]
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Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
[Cell Biology and Toxicology]
Song, Y., Wang, B., Zhu, X., Hu, J., Sun, J., Xuan, J., & Ge, Z. (2020). Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09530-8 Cite
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Autism-Associated SHANK3 Mutations Impair Maturation of Neuromuscular Junctions and Striated Muscles

Investigators used a combination of patient-derived human iPSCs, Shank3Δ11(−/−) mice, and Phelan-McDermid syndrome muscle biopsies from patients of different ages to analyze the role of SHANK3 on motor unit development.
[Science Translational Medicine]
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Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

In Dog and Human, the authors described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]

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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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miR-195 Enhances Cardiomyogenic Differentiation of the Proepicardium/Septum Transversum by Smurf1 and Foxp1 Modulation

Investigators provide a comprehensive characterization of the developmental expression profile of multiple microRNAs during epicardial development in chicken. They identified that miR-125, miR-146, miR-195 and miR-223 selectively enhanced cardiomyogenesis both in the proepicardium/ST explants as well as in the embryonic epicardium, a Smurf1- and Foxp1-driven process.
[Scientific Reports]
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Cell Type Specific Adhesion to Surfaces Functionalised by Amine Plasma Polymers

The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.
[Scientific Reports]
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Human Umbilical Cord Blood-Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Overexpression of divalent metal transporter 1 (DMT1) promoted H/R-induced myocardial cell ferroptosis, while knockdown of DMT1 significantly inhibited the ferroptosis.
[Cell Biology and Toxicology]
Song, Y., Wang, B., Zhu, X., Hu, J., Sun, J., Xuan, J., & Ge, Z. (2020). Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09530-8 Cite
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