Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Sarepta Therapeutics and Codiak BioSciences Collaborate to Research and Develop Exosome-Based Therapeutics for Rare Diseases

Sarepta Therapeutics, Inc. and Codiak BioSciences, Inc. announced a global research and option agreement to design and develop engineered exosome therapeutics to deliver gene therapy, gene editing and RNA technologies for neuromuscular diseases.
[Sarepta Therapeutics, Inc.]
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Clonally Expanding Smooth Muscle Cells Promote Atherosclerosis by Escaping Efferocytosis and Activating the Complement Cascade

Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]
Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., Howe, K. L., Jarr, K.-U., Flores, A. M., Tsantilas, P., Tsao, N., Rao, A., Newman, A. A. C., Eberhard, A. V., Priest, J. R., Ruusalepp, A., Pasterkamp, G., Maegdefessel, L., Miller, C. L., … Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006348117 Cite
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Human MuStem Cell Grafting Into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

Researchers described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]
Human MuStem cell grafting into infarcted rat heart attenuates adverse tissue remodeling and preserves cardiac function hMuStem cells preserve function of infarcted heart: Molecular Therapy - Methods & Clinical Development. (n.d.). Retrieved June 17, 2020, from https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30133-9 Cite
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Yin Yang 1 Is Required for PHD Finger Protein 20-Mediated Myogenic Differentiation In Vitro and In Vivo

Investigators found that protein and mRNA expression levels of PHF20 were decreased during myogenic differentiation in C2C12 cells.
[Cell Death & Differentiation]
Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo | Cell Death & Differentiation. (n.d.). Retrieved June 18, 2020, from https://www.nature.com/articles/s41418-020-0580-6 Cite
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Dissecting Myogenin-Mediated Retinoid X Receptor Signaling in Myogenic Differentiation

The authors found that rexinoid x receptor signaling associated with the distribution of myogenin at poised enhancers and a distinct E-box motif. They also found an association of myogenin with rexinoid-responsive gene expression and identified an epigenetic signature related to histone acetyltransferase p300.
[Communications Biology]
Khilji, S., Hamed, M., Chen, J., & Li, Q. (2020). Dissecting myogenin-mediated retinoid X receptor signaling in myogenic differentiation. Communications Biology, 3(1), 1–12. https://doi.org/10.1038/s42003-020-1043-9 Cite
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Intracellular Calcium Leak in Heart Failure and Atrial Fibrillation: A Unifying Mechanism and Therapeutic Target

The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]
Dridi, H., Kushnir, A., Zalk, R., Yuan, Q., Melville, Z., & Marks, A. R. (2020). Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target. Nature Reviews Cardiology, 1–16. https://doi.org/10.1038/s41569-020-0394-8 Cite
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The Importance of the ZBED6-IGF2 Axis for Metabolic Regulation in Mouse Myoblast Cells

Scientists showed a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6−/− myoblasts.
[FASEB Journal]
Younis, S., Naboulsi, R., Wang, X., Cao, X., Larsson, M., Sargsyan, E., Bergsten, P., Welsh, N., & Andersson, L. (n.d.). The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.201901321R Cite
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