Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

The authors validated defects in neuronal endosomal traffic by showing altered localization of amyloid precursor protein (APP) in early endosomes, a site of APP cleavage by the β-secretase.
[Cell Reports]
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30696-3 Cite
Full ArticleGraphical Abstract

Continue reading “Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing”

Bookmark

No account yet? Register

0
Share

NitroSynapsin Ameliorates Hypersynchronous Neural Network Activity in Alzheimer hiPSC Models

Scientists developed a platform of physiological assays using patch-clamp electrophysiology, calcium imaging, and multielectrode array experiments on human (h)iPSC-derived 2D cortical neuronal cultures and 3D cerebral organoids.
[Molecular Psychiatry]
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models | Molecular Psychiatry. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41380-020-0776-7 Cite
Abstract

Continue reading “NitroSynapsin Ameliorates Hypersynchronous Neural Network Activity in Alzheimer hiPSC Models”

Bookmark

No account yet? Register

0
Share

Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy

Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy | Cell Death & Disease. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41419-020-2615-9 Cite
Full Article

Continue reading “Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy”

Bookmark

No account yet? Register

0
Share

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

In cerebral organoids, transduction with recombinant adeno associated virus (rAAV)5 led to higher levels of vector DNA, transgenic mRNA and protein expression as compared to rAAV9. The superior transduction of rAAV5 was replicated in iPSC-derived neuronal cells.
[Molecular therapy-Nucleic Acids]
Depla, J. A., Sogorb-Gonzalez, M., Mulder, L., Heine, V. M., Konstantinova, P., Deventer, S. J. van, Wolthers, K. C., Pajkrt, D., Sridhar, A., & Evers, M. M. (2020). Cerebral organoids: a human model for AAV capsid selection and therapeutic transgene efficacy in the brain. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.05.028 Cite
AbstractFull ArticleGraphical Abstract

Continue reading “Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain”

Bookmark

No account yet? Register

0
Share

Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

The authors validated defects in neuronal endosomal traffic by showing altered localization of amyloid precursor protein (APP) in early endosomes, a site of APP cleavage by the β-secretase.
[Cell Reports]
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30696-3 Cite
Full ArticleGraphical Abstract

Continue reading “Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing”

Bookmark

No account yet? Register

0
Share

NitroSynapsin Ameliorates Hypersynchronous Neural Network Activity in Alzheimer hiPSC Models

Scientists developed a platform of physiological assays using patch-clamp electrophysiology, calcium imaging, and multielectrode array experiments on human (h)iPSC-derived 2D cortical neuronal cultures and 3D cerebral organoids.
[Molecular Psychiatry]
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models | Molecular Psychiatry. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41380-020-0776-7 Cite
Abstract

Continue reading “NitroSynapsin Ameliorates Hypersynchronous Neural Network Activity in Alzheimer hiPSC Models”

Bookmark

No account yet? Register

0
Share

Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy

Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy | Cell Death & Disease. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41419-020-2615-9 Cite
Full Article

Continue reading “Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy”

Bookmark

No account yet? Register

0
Share

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

Scientists unveiled a widespread and highly dynamic splicing program that affects synaptic genes in cerebellar neurons.
[Cell Reports]
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30673-2 Cite
Full ArticleGraphical Abstract

Continue reading “A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum”

Bookmark

No account yet? Register

0
Share

Dilp-2-Mediated PI3-Kinase Activation Coordinates Reactivation of Quiescent Neuroblasts with Growth of Their Glial Stem Cell Niche

Investigators found that Drosophila insulin-like peptide (Dilp)-2 was required for PI3-kinase activation and growth coordination between neuroblasts and glia in the brain.
[PLoS Biology]
Dilp-2–mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche. (n.d.). Retrieved June 4, 2020, from https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000721 Cite
Full Article

Continue reading “Dilp-2-Mediated PI3-Kinase Activation Coordinates Reactivation of Quiescent Neuroblasts with Growth of Their Glial Stem Cell Niche”

Bookmark

No account yet? Register

0
Share

Brain Organoids: An Ensemble of Bioassays to Investigate Human Neurodevelopment and Disease

The authors summarize how the diverse brain organoid methods can be utilized to enhance our understanding of brain disorders.
[Cell Death and Differentiation]
Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease | Cell Death & Differentiation. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41418-020-0566-4 Cite
Abstract

Continue reading “Brain Organoids: An Ensemble of Bioassays to Investigate Human Neurodevelopment and Disease”

Bookmark

No account yet? Register

0
Share

Nascent Biotech to Begin Phase I Human Trials for Brain Cancer Drug

Nascent Biotech, Inc. announced that the company will soon begin Phase I clinical trials for a treatment of brain cancer, including, glioblastoma, the deadliest form of brain cancer.
[Nascent Biotech]
Abstract

Continue reading “Nascent Biotech to Begin Phase I Human Trials for Brain Cancer Drug”

Bookmark

No account yet? Register

0
Share

The Pandemic Is Challenging China’s Breakneck Race to the Top of Science

When COVID-19 hit, China was close to surpassing the United States as the leading science funder, two years after it took top place as the biggest producer of scientific articles. And the country has boosted science around the world by supplying other regions with graduate students and postdoctoral scholars, who now number in the hundreds of thousands a year.
[Nature News]
Abstract

Continue reading “The Pandemic Is Challenging China’s Breakneck Race to the Top of Science”

Bookmark

No account yet? Register

0
Share
Share