Dual Role of WISP1 in Maintaining Glioma Stem Cells and Tumor-Supportive Macrophages in Glioblastoma

Researchers showed that glioma stem cells (GSCs) secreted the Wnt‐induced signaling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both GSCs and tumor-associated macrophages.
[Nature Communications]
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A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

Scientists unveiled a widespread and highly dynamic splicing program that affects synaptic genes in cerebellar neurons.
[Cell Reports]
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Dilp-2-Mediated PI3-Kinase Activation Coordinates Reactivation of Quiescent Neuroblasts with Growth of Their Glial Stem Cell Niche

Investigators found that Drosophila insulin-like peptide (Dilp)-2 was required for PI3-kinase activation and growth coordination between neuroblasts and glia in the brain.
[PLoS Biology]
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Brain Organoids: An Ensemble of Bioassays to Investigate Human Neurodevelopment and Disease

The authors summarize how the diverse brain organoid methods can be utilized to enhance our understanding of brain disorders.
[Cell Death and Differentiation]
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Nascent Biotech to Begin Phase I Human Trials for Brain Cancer Drug

Nascent Biotech, Inc. announced that the company will soon begin Phase I clinical trials for a treatment of brain cancer, including, glioblastoma, the deadliest form of brain cancer.
[Nascent Biotech]
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The Pandemic Is Challenging China’s Breakneck Race to the Top of Science

When COVID-19 hit, China was close to surpassing the United States as the leading science funder, two years after it took top place as the biggest producer of scientific articles. And the country has boosted science around the world by supplying other regions with graduate students and postdoctoral scholars, who now number in the hundreds of thousands a year.
[Nature News]
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CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

Researchers showed that CD49f was a novel marker for human astrocytes, expressed in fetal and adult brains from healthy and diseased individuals.
[Neuron]
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Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

In cerebral organoids, transduction with recombinant adeno associated virus (rAAV)5 led to higher levels of vector DNA, transgenic mRNA and protein expression as compared to rAAV9. The superior transduction of rAAV5 was replicated in iPSC-derived neuronal cells.
[Molecular therapy-Nucleic Acids]
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Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

The authors validated defects in neuronal endosomal traffic by showing altered localization of amyloid precursor protein (APP) in early endosomes, a site of APP cleavage by the β-secretase.
[Cell Reports]
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NitroSynapsin Ameliorates Hypersynchronous Neural Network Activity in Alzheimer hiPSC Models

Scientists developed a platform of physiological assays using patch-clamp electrophysiology, calcium imaging, and multielectrode array experiments on human (h)iPSC-derived 2D cortical neuronal cultures and 3D cerebral organoids.
[Molecular Psychiatry]
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Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy

Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
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