Researchers showed that glioma stem cells (GSCs) secreted the Wnt‐induced signaling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both GSCs and tumor-associated macrophages.
[Nature Communications]
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Category Archives: Neural Cell
Neural Cell NewsNeural Cell News is an online publication and email newsletter covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Neural Cell News is an online publication to help scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
Dual Role of WISP1 in Maintaining Glioma Stem Cells and Tumor-Supportive Macrophages in Glioblastoma
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum
Scientists unveiled a widespread and highly dynamic splicing program that affects synaptic genes in cerebellar neurons.
[Cell Reports]
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30673-2 Cite
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Dilp-2-Mediated PI3-Kinase Activation Coordinates Reactivation of Quiescent Neuroblasts with Growth of Their Glial Stem Cell Niche
Investigators found that Drosophila insulin-like peptide (Dilp)-2 was required for PI3-kinase activation and growth coordination between neuroblasts and glia in the brain.
[PLoS Biology]
Dilp-2–mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche. (n.d.). Retrieved June 4, 2020, from https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000721 Cite
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Brain Organoids: An Ensemble of Bioassays to Investigate Human Neurodevelopment and Disease
The authors summarize how the diverse brain organoid methods can be utilized to enhance our understanding of brain disorders.
[Cell Death and Differentiation]
Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease | Cell Death & Differentiation. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41418-020-0566-4 Cite
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Nascent Biotech to Begin Phase I Human Trials for Brain Cancer Drug
The Pandemic Is Challenging China’s Breakneck Race to the Top of Science
When COVID-19 hit, China was close to surpassing the United States as the leading science funder, two years after it took top place as the biggest producer of scientific articles. And the country has boosted science around the world by supplying other regions with graduate students and postdoctoral scholars, who now number in the hundreds of thousands a year.
[Nature News]
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CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes
Researchers showed that CD49f was a novel marker for human astrocytes, expressed in fetal and adult brains from healthy and diseased individuals.
[Neuron]
CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes: Neuron. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/neuron/fulltext/S0896-6273(20)30360-3 Cite
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Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain
In cerebral organoids, transduction with recombinant adeno associated virus (rAAV)5 led to higher levels of vector DNA, transgenic mRNA and protein expression as compared to rAAV9. The superior transduction of rAAV5 was replicated in iPSC-derived neuronal cells.
[Molecular therapy-Nucleic Acids]
Depla, J. A., Sogorb-Gonzalez, M., Mulder, L., Heine, V. M., Konstantinova, P., Deventer, S. J. van, Wolthers, K. C., Pajkrt, D., Sridhar, A., & Evers, M. M. (2020). Cerebral organoids: a human model for AAV capsid selection and therapeutic transgene efficacy in the brain. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.05.028 Cite
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Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing
The authors validated defects in neuronal endosomal traffic by showing altered localization of amyloid precursor protein (APP) in early endosomes, a site of APP cleavage by the β-secretase.
[Cell Reports]
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30696-3 Cite
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NitroSynapsin Ameliorates Hypersynchronous Neural Network Activity in Alzheimer hiPSC Models
Scientists developed a platform of physiological assays using patch-clamp electrophysiology, calcium imaging, and multielectrode array experiments on human (h)iPSC-derived 2D cortical neuronal cultures and 3D cerebral organoids.
[Molecular Psychiatry]
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models | Molecular Psychiatry. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41380-020-0776-7 Cite
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Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy
Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy | Cell Death & Disease. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41419-020-2615-9 Cite
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