Cancer Stem Cell News Volume 10.01 | Jan 13 2021







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Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.01 – 13 January, 2021
TOP STORY

A
Nanotherapeutic Strategy to Overcome Chemotherapeutic Resistance of Cancer Stem-Like Cells

Investigators report a nanotherapeutic strategy to kill CSCs in tumors using nanoparticles that were co-loaded with the differentiation-inducing agent, all-trans retinoic acid, and the chemotherapeutic drug, camptothecin.
[Nature Nanotechnology]

Abstract

Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
PUBLICATIONSRanked by the impact factor of the journal

Chemotherapy-Enriched
THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

The local soft spots created by liver CSCs could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis.
[Advanced Science]

Full Article

Targeting
of Glioma Stem-Like Cells with a Parthenolide Derivative ACT001 through Inhibition of AEBP1/PI3K/AKT Signaling

The effects of ACT001 on cell survival of normal human astrocytes and patient-derived glioma stem-like cells were evaluated. RNA-Seq were performed to detect differentially expressed genes.
[Theranostics]

Full Article

Single-Cell
Chromatin Accessibility Profiling of Glioblastoma Identifies an Invasive Cancer Stem Cell Population Associated with Lower Survival

Researchers showed, using single-cell chromatin accessibility, that primary human glioblastomas (GBMs) harbored a heterogeneous self-renewing population whose diversity was captured in patient-derived GBMs stem cells.
[eLife]

Abstract

The Chick Chorioallantoic Membrane Model: A New In Vivo
Tool to Evaluate Breast Cancer Stem Cell Activity

The authors established a CAM-LDA assay able to rapidly reproduce tumor specificities- in particular, the ability of the small population of CSCs to form tumors.
[International Journal of Molecular Sciences]

Full Article

Dysfunctional
EGFR and Oxidative Stress-Induced PKD1 Signaling Drive Formation of DCLK1+ Pancreatic Stem Cells

While PanIN cells expressed oncogenic KRas and have increased activity of epidermal growth factor receptor (EGFR), scientists demonstrated that in doublecortin-like kinase 1 (DCLK1+) PanIN cells EGFR signaling was not propagated to the nucleus.
[iScience]

AbstractGraphical Abstract

ADAMTS1
Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
[Biomolecules]

Full Article

Circulating
Tumor DNA Is Detectable in Canine Histiocytic Sarcoma, Oral Malignant Melanoma, and Multicentric Lymphoma

Researchers used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. They detected circulating tumor DNA in 21/23 of histiocytic sarcoma, 2/8 of oral melanoma, and 12/13 of lymphoma cases.
[Scientific Reports]

Full Article

CCAAT/Enhancer-Binding
Protein Delta Mediates Glioma Stem-Like Cell Enrichment and ATP-Binding Cassette Transporter ABCA1 Activation for Temozolomide Resistance in Glioblastoma

Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery]

Full Article

How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
REVIEWS

The Role of E3 Ubiquitin Ligases in the Development and Progression of Glioblastoma

The authors consider how knowledge of E3 ligase biology may be used for future therapeutic interventions in glioblastoma, including the use of blood-brain barrier permeable proteolysis targeting chimeras.
[Cell Death & Differentiation]

Full ArticleGraphical Abstract

Glioma Stem Cells and Their Roles within the Hypoxic Tumor Microenvironment

Investigators summarize the impact of hypoxia and acidic stress on glioma stem cell signaling and biologic phenotypes, and potential methods to inhibit these pathways.
[Theranostics]

Full Article
INDUSTRY AND POLICY NEWS


New Treatment for Central Nervous System Tumors Enters Phase I Clinical Trials

OX2 Therapeutics, Inc. announced that they treated their first patient in a Phase I human trial of a new treatment developed to combat recurrent high-grade brain tumors.
[OX2 Therapeutics, Inc. (Business Wire, Inc.)]

Press Release
FEATURED EVENT

The European Society for Blood and Marrow Transplantation

March 14 – 17, 2021
Virtual


> See All Events

JOB OPPORTUNITIES

Staff
Scientist – Medulloblastoma

St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

Senior
Research Assistant – Targeted Therapy in Breast Cancer

Baylor College of Medicine – Houston, Texas, United States

Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

Salk Institute of Biological Studies – La Jolla, California, United States

Faculty Position – Skin Cancer

Columbia University Medical Center – New York, New York, United States

Senior
Investigator – Replication Stress and Chromatin Alterations

NIH National Cancer Institute – Bethesda, Maryland, United States

> See All Jobs

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