 | | Vol. 10.01 – 13 January, 2021 |
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| Investigators report a nanotherapeutic strategy to kill CSCs in tumors using nanoparticles that were co-loaded with the differentiation-inducing agent, all-trans retinoic acid, and the chemotherapeutic drug, camptothecin.
[Nature Nanotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The local soft spots created by liver CSCs could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis.
[Advanced Science] |
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| The effects of ACT001 on cell survival of normal human astrocytes and patient-derived glioma stem-like cells were evaluated. RNA-Seq were performed to detect differentially expressed genes.
[Theranostics] |
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| Researchers showed, using single-cell chromatin accessibility, that primary human glioblastomas (GBMs) harbored a heterogeneous self-renewing population whose diversity was captured in patient-derived GBMs stem cells.
[eLife] |
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| The authors established a CAM-LDA assay able to rapidly reproduce tumor specificities- in particular, the ability of the small population of CSCs to form tumors.
[International Journal of Molecular Sciences] |
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| While PanIN cells expressed oncogenic KRas and have increased activity of epidermal growth factor receptor (EGFR), scientists demonstrated that in doublecortin-like kinase 1 (DCLK1+) PanIN cells EGFR signaling was not propagated to the nucleus.
[iScience] |
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| The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
[Biomolecules] |
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| Researchers used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. They detected circulating tumor DNA in 21/23 of histiocytic sarcoma, 2/8 of oral melanoma, and 12/13 of lymphoma cases.
[Scientific Reports] |
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| Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery] |
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| The authors consider how knowledge of E3 ligase biology may be used for future therapeutic interventions in glioblastoma, including the use of blood-brain barrier permeable proteolysis targeting chimeras.
[Cell Death & Differentiation] |
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| Investigators summarize the impact of hypoxia and acidic stress on glioma stem cell signaling and biologic phenotypes, and potential methods to inhibit these pathways.
[Theranostics] |
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| OX2 Therapeutics, Inc. announced that they treated their first patient in a Phase I human trial of a new treatment developed to combat recurrent high-grade brain tumors.
[OX2 Therapeutics, Inc. (Business Wire, Inc.)] |
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| March 14 – 17, 2021
Virtual |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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