Cancer Stem Cell News Volume 10.01 | Jan 13 2021

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    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.01 – 13 January, 2021
    TOP STORY

    A
    Nanotherapeutic Strategy to Overcome Chemotherapeutic Resistance of Cancer Stem-Like Cells

    Investigators report a nanotherapeutic strategy to kill CSCs in tumors using nanoparticles that were co-loaded with the differentiation-inducing agent, all-trans retinoic acid, and the chemotherapeutic drug, camptothecin.
    [Nature Nanotechnology]

    Abstract

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Chemotherapy-Enriched
    THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

    The local soft spots created by liver CSCs could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis.
    [Advanced Science]

    Full Article

    Targeting
    of Glioma Stem-Like Cells with a Parthenolide Derivative ACT001 through Inhibition of AEBP1/PI3K/AKT Signaling

    The effects of ACT001 on cell survival of normal human astrocytes and patient-derived glioma stem-like cells were evaluated. RNA-Seq were performed to detect differentially expressed genes.
    [Theranostics]

    Full Article

    Single-Cell
    Chromatin Accessibility Profiling of Glioblastoma Identifies an Invasive Cancer Stem Cell Population Associated with Lower Survival

    Researchers showed, using single-cell chromatin accessibility, that primary human glioblastomas (GBMs) harbored a heterogeneous self-renewing population whose diversity was captured in patient-derived GBMs stem cells.
    [eLife]

    Abstract

    The Chick Chorioallantoic Membrane Model: A New In Vivo
    Tool to Evaluate Breast Cancer Stem Cell Activity

    The authors established a CAM-LDA assay able to rapidly reproduce tumor specificities- in particular, the ability of the small population of CSCs to form tumors.
    [International Journal of Molecular Sciences]

    Full Article

    Dysfunctional
    EGFR and Oxidative Stress-Induced PKD1 Signaling Drive Formation of DCLK1+ Pancreatic Stem Cells

    While PanIN cells expressed oncogenic KRas and have increased activity of epidermal growth factor receptor (EGFR), scientists demonstrated that in doublecortin-like kinase 1 (DCLK1+) PanIN cells EGFR signaling was not propagated to the nucleus.
    [iScience]

    AbstractGraphical Abstract

    ADAMTS1
    Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

    The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
    [Biomolecules]

    Full Article

    Circulating
    Tumor DNA Is Detectable in Canine Histiocytic Sarcoma, Oral Malignant Melanoma, and Multicentric Lymphoma

    Researchers used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. They detected circulating tumor DNA in 21/23 of histiocytic sarcoma, 2/8 of oral melanoma, and 12/13 of lymphoma cases.
    [Scientific Reports]

    Full Article

    CCAAT/Enhancer-Binding
    Protein Delta Mediates Glioma Stem-Like Cell Enrichment and ATP-Binding Cassette Transporter ABCA1 Activation for Temozolomide Resistance in Glioblastoma

    Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
    [Cell Death Discovery]

    Full Article

    How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
    REVIEWS

    The Role of E3 Ubiquitin Ligases in the Development and Progression of Glioblastoma

    The authors consider how knowledge of E3 ligase biology may be used for future therapeutic interventions in glioblastoma, including the use of blood-brain barrier permeable proteolysis targeting chimeras.
    [Cell Death & Differentiation]

    Full ArticleGraphical Abstract

    Glioma Stem Cells and Their Roles within the Hypoxic Tumor Microenvironment

    Investigators summarize the impact of hypoxia and acidic stress on glioma stem cell signaling and biologic phenotypes, and potential methods to inhibit these pathways.
    [Theranostics]

    Full Article
    INDUSTRY AND POLICY NEWS


    New Treatment for Central Nervous System Tumors Enters Phase I Clinical Trials

    OX2 Therapeutics, Inc. announced that they treated their first patient in a Phase I human trial of a new treatment developed to combat recurrent high-grade brain tumors.
    [OX2 Therapeutics, Inc. (Business Wire, Inc.)]

    Press Release
    FEATURED EVENT

    The European Society for Blood and Marrow Transplantation

    March 14 – 17, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Staff
    Scientist – Medulloblastoma

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Senior
    Research Assistant – Targeted Therapy in Breast Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

    Salk Institute of Biological Studies – La Jolla, California, United States

    Faculty Position – Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    Senior
    Investigator – Replication Stress and Chromatin Alterations

    NIH National Cancer Institute – Bethesda, Maryland, United States

    > See All Jobs

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