Cancer Stem Cell News Volume 10.02 | Jan 20 2021

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    2021-01-20 | CSCN 10.02


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.02 – 20 January, 2021
    TOP STORY

    Adrenomedullin-CALCRL
    Axis Controls Relapse-Initiating Drug Tolerant Acute Myeloid Leukemia Cells

    Calcitonin receptor-like receptor (CALCRL) knockdown impaired leukemic growth, decreased leukemic stem cell frequency, and sensitized to cytarabine in patient-derived xenograft models.
    [Nature Communications]

    Full Article


    How can evaluating the immuno-oncology potential of compounds in vitro predict clinical outcomes? Watch this webinar by Dr. Alison O'Mahony, Eurofins DiscoverX
    PUBLICATIONSRanked by the impact factor of the journal

    Dll1+
    Quiescent Tumor Stem Cells Drive Chemoresistance in Breast Cancer through NF-κB Survival Pathway

    Using conditional knockout and reporter mouse models, the authors demonstrated that tumor cells expressing the Notch ligand Dll1 was important for tumor growth and metastasis and bear similarities to tumor-initiating cancer cells in breast cancer.
    [Nature Communications]

    Full Article

    Interplay between Desmoglein2 and Hypoxia Controls Metastasis in Breast Cancer

    Investigators found that high expression of desmoglein2, a component of desmosome-mediated intercellular adhesion complexes, promoted tumor growth, increased the prevalence of circulating tumor cell clusters, and facilitated distant organ colonization.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Thrombospondin
    4/Integrin α2/HSF1 Axis Promotes Proliferation and Cancer Stem-Like Traits of Gallbladder Cancer by Enhancing Reciprocal Crosstalk between Cancer-Associated Fibroblasts and Tumor Cells

    Peritumoral fibroblasts and cancer-associated fibroblasts were extracted from gallbladder cancer (GBC) tissues. Thrombospondin expression in GBC was screened by RT-qPCR.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Autophagy
    Augments the Self-Renewal of Lung Cancer Stem Cells by the Degradation of Ubiquitinated p53

    By generating stable human lung cancer stem cell (CSC) cell lines with the wild-type TP53, as well as cell lines in which TP53 was deleted, the authors showed, for the first time, that autophagy augments the stemness of lung CSCs by degrading ubiquitinated p53.
    [Cell Death & Disease]

    Full Article

    PI3K/Akt Pathway and Nanog Maintain Cancer Stem Cells in Sarcomas

    Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
    [Oncogenesis]

    Full Article

    CD117/C-Kit
    Defines a Prostate CSC-Like Subpopulation Driving Progression and TKI Resistance

    To determine how CD117 expression and activation by its ligand stem cell factor alters prostate cancer aggressiveness, researchers used C4-2 and PC3-mm human prostate cancer cells, which contained a CD117+ subpopulation.
    [Scientific Reports]

    Full Article

    Circulating
    Tumor Cells as an Indicator of Early and Systemic Recurrence after Surgical Resection in Pancreatic Ductal Adenocarcinoma

    Scientists determined whether circulating tumor cells exist in the blood of pancreatic ductal adenocarcinoma patients and can be used as a predictor of recurrence patterns after surgical resection.
    [Scientific Reports]

    Full Article

    Role of Runx2 in Prostate Development and Stem Cell Function

    Selective growth of murine prostate epithelium under non‐adherent conditions was used to enrich for stem cells. Expression of runt domain transcription factors, stem cell and prostate marker messenger RNAs was determined by quantitative reverse transcription polymerase chain reaction.
    [Prostate]

    Abstract


    Survey Report: Where Is Pluripotent Stem Cell Research Now?
    REVIEWS

    Liquid Biopsy Enters the Clinic – Implementation Issues and Future Challenges

    The authors discuss key issues and gaps in technology, clinical trial methodologies and logistics for the eventual integration of liquid biopsy into the clinical workflow.
    [Nature Reviews Clinical Oncology]

    Abstract

    Advances in Liver Cancer Stem Cell Isolation and their Characterization

    Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    MicroRNA
    Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

    Scientists summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
    [Cancer Cell International]

    Full Article
    INDUSTRY AND POLICY NEWS

    Neurogene and University of Edinburgh Announce Research Collaboration to Advance Next Generation Gene Therapies

    Neurogene Inc. and the University of Edinburgh announced a collaboration to advance development of multiple platform approaches designed to enable next generation gene therapies. The collaboration provides comprehensive research capabilities to Neurogene, enabling the company and the university to expedite a multiple platform approach to improve upon existing gene therapy technologies.
    [Neurogene Inc.]

    Press Release

    Vor
    Announces FDA Clearance of IND Application for VOR33

    Vor Biopharma announced that the FDA has cleared the company’s Investigational New Drug (IND) application for VOR33, an engineered hematopoietic stem cell therapy candidate being developed for the treatment of acute myeloid leukemia.
    [Vor Biopharma]

    Press Release
    FEATURED EVENT

    AACR: COVID-19 and Cancer

    February 3 – 5, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Pediatric Myeloid Tumors

    St. Jude Children’s Hospital – Memphis, Tennessee, United States

    Staff
    Scientist – Medulloblastoma

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Senior
    Research Assistant – Targeted Therapy in Breast Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

    Salk Institute of Biological Studies – La Jolla, California, United States

    Faculty Position – Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    > See All Jobs

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