Cancer Stem Cell News Volume 10.02 | Jan 20 2021







2021-01-20 | CSCN 10.02


Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.02 – 20 January, 2021
TOP STORY

Adrenomedullin-CALCRL
Axis Controls Relapse-Initiating Drug Tolerant Acute Myeloid Leukemia Cells

Calcitonin receptor-like receptor (CALCRL) knockdown impaired leukemic growth, decreased leukemic stem cell frequency, and sensitized to cytarabine in patient-derived xenograft models.
[Nature Communications]

Full Article


How can evaluating the immuno-oncology potential of compounds in vitro predict clinical outcomes? Watch this webinar by Dr. Alison O'Mahony, Eurofins DiscoverX
PUBLICATIONSRanked by the impact factor of the journal

Dll1+
Quiescent Tumor Stem Cells Drive Chemoresistance in Breast Cancer through NF-κB Survival Pathway

Using conditional knockout and reporter mouse models, the authors demonstrated that tumor cells expressing the Notch ligand Dll1 was important for tumor growth and metastasis and bear similarities to tumor-initiating cancer cells in breast cancer.
[Nature Communications]

Full Article

Interplay between Desmoglein2 and Hypoxia Controls Metastasis in Breast Cancer

Investigators found that high expression of desmoglein2, a component of desmosome-mediated intercellular adhesion complexes, promoted tumor growth, increased the prevalence of circulating tumor cell clusters, and facilitated distant organ colonization.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Thrombospondin
4/Integrin α2/HSF1 Axis Promotes Proliferation and Cancer Stem-Like Traits of Gallbladder Cancer by Enhancing Reciprocal Crosstalk between Cancer-Associated Fibroblasts and Tumor Cells

Peritumoral fibroblasts and cancer-associated fibroblasts were extracted from gallbladder cancer (GBC) tissues. Thrombospondin expression in GBC was screened by RT-qPCR.
[Journal of Experimental & Clinical Cancer Research]

Full Article

Autophagy
Augments the Self-Renewal of Lung Cancer Stem Cells by the Degradation of Ubiquitinated p53

By generating stable human lung cancer stem cell (CSC) cell lines with the wild-type TP53, as well as cell lines in which TP53 was deleted, the authors showed, for the first time, that autophagy augments the stemness of lung CSCs by degrading ubiquitinated p53.
[Cell Death & Disease]

Full Article

PI3K/Akt Pathway and Nanog Maintain Cancer Stem Cells in Sarcomas

Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
[Oncogenesis]

Full Article

CD117/C-Kit
Defines a Prostate CSC-Like Subpopulation Driving Progression and TKI Resistance

To determine how CD117 expression and activation by its ligand stem cell factor alters prostate cancer aggressiveness, researchers used C4-2 and PC3-mm human prostate cancer cells, which contained a CD117+ subpopulation.
[Scientific Reports]

Full Article

Circulating
Tumor Cells as an Indicator of Early and Systemic Recurrence after Surgical Resection in Pancreatic Ductal Adenocarcinoma

Scientists determined whether circulating tumor cells exist in the blood of pancreatic ductal adenocarcinoma patients and can be used as a predictor of recurrence patterns after surgical resection.
[Scientific Reports]

Full Article

Role of Runx2 in Prostate Development and Stem Cell Function

Selective growth of murine prostate epithelium under non‐adherent conditions was used to enrich for stem cells. Expression of runt domain transcription factors, stem cell and prostate marker messenger RNAs was determined by quantitative reverse transcription polymerase chain reaction.
[Prostate]

Abstract


Survey Report: Where Is Pluripotent Stem Cell Research Now?
REVIEWS

Liquid Biopsy Enters the Clinic – Implementation Issues and Future Challenges

The authors discuss key issues and gaps in technology, clinical trial methodologies and logistics for the eventual integration of liquid biopsy into the clinical workflow.
[Nature Reviews Clinical Oncology]

Abstract

Advances in Liver Cancer Stem Cell Isolation and their Characterization

Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
[Stem Cell Reviews and Reports]

AbstractGraphical Abstract

MicroRNA
Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

Scientists summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]

Full Article
INDUSTRY AND POLICY NEWS

Neurogene and University of Edinburgh Announce Research Collaboration to Advance Next Generation Gene Therapies

Neurogene Inc. and the University of Edinburgh announced a collaboration to advance development of multiple platform approaches designed to enable next generation gene therapies. The collaboration provides comprehensive research capabilities to Neurogene, enabling the company and the university to expedite a multiple platform approach to improve upon existing gene therapy technologies.
[Neurogene Inc.]

Press Release

Vor
Announces FDA Clearance of IND Application for VOR33

Vor Biopharma announced that the FDA has cleared the company’s Investigational New Drug (IND) application for VOR33, an engineered hematopoietic stem cell therapy candidate being developed for the treatment of acute myeloid leukemia.
[Vor Biopharma]

Press Release
FEATURED EVENT

AACR: COVID-19 and Cancer

February 3 – 5, 2021
Virtual


> See All Events

JOB OPPORTUNITIES

Research Associate – Pediatric Myeloid Tumors

St. Jude Children’s Hospital – Memphis, Tennessee, United States

Staff
Scientist – Medulloblastoma

St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

Senior
Research Assistant – Targeted Therapy in Breast Cancer

Baylor College of Medicine – Houston, Texas, United States

Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

Salk Institute of Biological Studies – La Jolla, California, United States

Faculty Position – Skin Cancer

Columbia University Medical Center – New York, New York, United States

> See All Jobs

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