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| Vol. 10.02 – 20 January, 2021
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Calcitonin receptor-like receptor (CALCRL) knockdown impaired leukemic growth, decreased leukemic stem cell frequency, and sensitized to cytarabine in patient-derived xenograft models.
[Nature Communications]
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| PUBLICATIONSRanked by the impact factor of the journal
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Using conditional knockout and reporter mouse models, the authors demonstrated that tumor cells expressing the Notch ligand Dll1 was important for tumor growth and metastasis and bear similarities to tumor-initiating cancer cells in breast cancer.
[Nature Communications]
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Investigators found that high expression of desmoglein2, a component of desmosome-mediated intercellular adhesion complexes, promoted tumor growth, increased the prevalence of circulating tumor cell clusters, and facilitated distant organ colonization.
[Proceedings of the National Academy of Sciences of the United States of America]
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Peritumoral fibroblasts and cancer-associated fibroblasts were extracted from gallbladder cancer (GBC) tissues. Thrombospondin expression in GBC was screened by RT-qPCR.
[Journal of Experimental & Clinical Cancer Research]
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By generating stable human lung cancer stem cell (CSC) cell lines with the wild-type TP53, as well as cell lines in which TP53 was deleted, the authors showed, for the first time, that autophagy augments the stemness of lung CSCs by degrading ubiquitinated p53.
[Cell Death & Disease]
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Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
[Oncogenesis]
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To determine how CD117 expression and activation by its ligand stem cell factor alters prostate cancer aggressiveness, researchers used C4-2 and PC3-mm human prostate cancer cells, which contained a CD117+ subpopulation.
[Scientific Reports]
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Scientists determined whether circulating tumor cells exist in the blood of pancreatic ductal adenocarcinoma patients and can be used as a predictor of recurrence patterns after surgical resection.
[Scientific Reports]
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Selective growth of murine prostate epithelium under non‐adherent conditions was used to enrich for stem cells. Expression of runt domain transcription factors, stem cell and prostate marker messenger RNAs was determined by quantitative reverse transcription polymerase chain reaction.
[Prostate]
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The authors discuss key issues and gaps in technology, clinical trial methodologies and logistics for the eventual integration of liquid biopsy into the clinical workflow.
[Nature Reviews Clinical Oncology]
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Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
[Stem Cell Reviews and Reports]
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Scientists summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
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Neurogene Inc. and the University of Edinburgh announced a collaboration to advance development of multiple platform approaches designed to enable next generation gene therapies. The collaboration provides comprehensive research capabilities to Neurogene, enabling the company and the university to expedite a multiple platform approach to improve upon existing gene therapy technologies.
[Neurogene Inc.]
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Vor Biopharma announced that the FDA has cleared the company’s Investigational New Drug (IND) application for VOR33, an engineered hematopoietic stem cell therapy candidate being developed for the treatment of acute myeloid leukemia.
[Vor Biopharma]
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February 3 – 5, 2021
Virtual
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| St. Jude Children’s Hospital – Memphis, Tennessee, United States
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States
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| Baylor College of Medicine – Houston, Texas, United States
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| Salk Institute of Biological Studies – La Jolla, California, United States
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| Columbia University Medical Center – New York, New York, United States
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Cancer Stem Cell News
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