 | | Vol. 10.05 – 10 February, 2021 |
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| Extensive pre-clinical studies in vitro and in vivo were carried out to establish the mechanism action of AT101 on targeting CSCs and antiapoptotic proteins.
[Gut] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Treatment of glioma cells with the dopamine receptor antagonist quetiapine reduced glioma cell self-renewal in vitro and combined treatment of mice with quetiapine and radiation prolonged the survival of glioma-bearing mice.
[JNCI-Journal of the National Cancer institute] |
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| Researchers showed that the replication stress response was efficient in primary CSCs from colorectal cancer, and described unique roles for PARP1 and MRE11/RAD51.
[Cell Death & Differentiation] |
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| Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced B lymphoma Mo-MLV insertion region 1 homolog an SRY-Box Transcription Factor 2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
[Cancers] |
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| The authors isolated and characterized breast CSCs from a triple-negative breast cancer cell line, MDA-MB-231. The obtained mammospheres were then treated with the specific PPARα antagonist GW6471, after which, glucose, lipid metabolism, and invasiveness were analyzed.
[Biomedicines] |
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| Researchers explored how prostate circulating tumor cells could resist cell death in response to forces of >1,000 dyn/cm2. The DU145, PC3, and LNCaP human prostate cancer cell lines were used to represent cells of different metastatic origins.
[Journal of Cell Science] |
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| Scientists evaluated the association of radiation response of cervical CSCs with clinical and morphological parameters of disease and features of human papillomavirus (HPV) infection.
[International Journal of Molecular Sciences] |
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| Researchers investigated the CSC‐promoting effect of factors released from myofibroblasts into the microenvironment of early colorectal cancer tumors and its molecular mechanism.
[Molecular Carcinogenesis] |
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| The authors outline the instances where aspects of an epithelial–mesenchymal transition (EMT) have been implicated in normal and neoplastic epithelial stem cells and consider the involvement of this programme during tissue regeneration and repair.
[Nature Reviews Cancer] |
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| Investigators summarize the epigenetic findings linked to miRNAome in the maintenance and regulation of colorectal cancer (CRC) stem cells (CCSCs), including their relationships with different signaling pathways, which should help to identify specific diagnostic, prognostic, and predictive biomarkers for CRC, but also develop innovative CCSCs-targeted therapies.
[International Journal of Molecular Sciences] |
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Apollomics, Inc. and Edison Oncology Announce Licensing Agreement for Novel Protein Tyrosine Kinase Inhibitor Targeting Solid Tumors | Apollomics, Inc. and Edison Oncology Holding Corp., announced that Apollomics has been granted worldwide rights, excluding China, Hong Kong and Taiwan, for the development and commercialization of EO1001. EO1001 is a protein tyrosine kinase inhibitor that has demonstrated irreversible inhibition of EGFR, HER2 and HER4 as a single agent.
[Apollomics, Inc.] |
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| China Oncology Focus Limited (COF) an affiliate of Lee’s Pharmaceutical Holdings Limited, and Sorrento Therapeutics, Inc. announced that its anti-PD-L1 antibody, socazolimab, licensed from Sorrento to COF for the greater China territory, has been granted breakthrough therapy designation by the China National Medical Products Administration to treat recurrent or metastatic cervical cancer.
[Lee’s Pharmaceutical] |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Gilead Sciences, Inc. – London, England, United Kingdom |
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| | University of Utah – Salt Lake City, Utah, United States |
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