Cancer Stem Cell News Volume 10.06 | Feb 17 2021

2021-02-17 | CSCN 10.06

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.06 – 17 February, 2021

PRMT5 Inhibition Disrupts Splicing and Stemness in Glioblastoma

Using two orthogonal-acting inhibitors of Protein arginine methyltransferase 5 (PRMT5), researchers showed that pharmacological inhibition of PRMT5 suppressed the growth of a cohort of 46 patient-derived glioblastoma stem cell cultures, with the proneural subtype showing greater sensitivity.
[Nature Communications]

Full Article

How can evaluating the immuno-oncology potential of compounds in vitro predict clinical outcomes? Watch this webinar by Dr. Alison O'Mahony, Eurofins DiscoverX
PUBLICATIONSRanked by the impact factor of the journal

Tumor Cell Plasticity, Heterogeneity, and Resistance in Crucial Microenvironmental Niches in Glioma

The authors identified NOTCH1 as a central switch between the perivascular niche and network niche in glioma, and demonstrated robust cross-compensation when only one niche was targeted.
[Nature Communications]

Full Article

YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer

Scientists showed that the receptor tyrosine kinase Met promoted YAP activity in basal-like breast cancer and found enhanced YAP activity within the CSC population.
[Cancer Research]


Reprogramming Transcription Factors Oct4 and Sox2 Induces a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells

Induction and function of BRD/H3k27Ac-dependent immunosuppressive genes played a role in the immunosuppressive phenotype of stem-like tumor-propagating cells in GBM.
[Cancer Research]


Regulatory T Cells Promote Glioma Cell Stemness through TGF-β–NF-κB–IL6–STAT3 Signaling

Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]

Full Article

Alpha-Enolase (ENO1), Identified as an Antigen to Monoclonal Antibody 12C7, Promotes the Self-Renewal and Malignant Phenotype of Lung Cancer Stem Cells by AMPK/mTOR Pathway

Immunofluorescence was used for antigen localization. After targeted antigen purification by electrophoresis and immunoblot, the antigen was identified by LC-MALDI-TOF/TOF mass spectrometry, immunofluorescence, and immunoprecipitation.
[Stem Cell Research & Therapy]

Full Article

The Combination Effect of Prominin1 (CD133) Suppression and Oxaliplatin Treatment in Colorectal Cancer Therapy

Scientists checked the combined effect of CD133 siRNA and Oxaliplatin on proliferation, migration, apoptosis, and stemness properties of olorectal cancer cells in the HT-29 cell line.
[Biomedicine & Pharmacotherapy]

Full ArticleGraphical Abstract

Macrophages Support the Aggressive Mechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

Investigators recapitulated the tumor cells-macrophages interactions in cell culture using prostate cancer cell lines.
[Biophysical Journal]


Exploitation of the Vitamin A/Retinoic Acid Axis Depletes ALDH1-Positive Cancer Stem Cells and Re-Sensitises Resistant Non-Small Cell Lung Cancer Cells to Cisplatin

The authors investigated the function of the CSC marker aldehyde dehydrogenase in retinoic acid cell signaling using an in vitro model of cisplatin resistant non-small cell lung cancer.
[Translational Oncology]

Full Article
Survey Report: Where Is Pluripotent Stem Cell Research Now?

Targeting Cancer Stem Cells for Reversing Therapy Resistance: Mechanism, Signaling, and Prospective Agents

Investigators review the identification of CSCs, the intrinsic and extrinsic mechanisms of therapy resistance in CSCs, the signaling pathways of CSCs that mediate treatment failure, and potential CSC-targeting agents in various tumors from the clinical perspective.
[Signal Transduction and Targeted Therapy]

Full Article

Mitochondrial Dynamics in Cancer Stem Cells

Many CSC phenotypes including metabolism, epithelial-to-mesenchymal transition, cellular signaling pathway activity, and others, arise from altered mitochondrial function and turnover, which are regulated by constant cycles of mitochondrial fusion and fission.
[Cellular and Molecular Life Sciences]


Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression

Investigators recapitulate the multifaceted action exerted by focal adhesion kinase and its prognostic significance in breast cancer.

Full Article

ORYZON Announces FDA Orphan Drug Designation Granted to iadademstat for Treatment of Acute Myeloid Leukemia

Oryzon Genomics, S.A. announced that the FDA has granted Orphan Drug Designation to the company’s first-in-class LSD1 inhibitor iadademstat for the treatment of patients with acute myeloid leukemia.
[Oryzon Genomics, S.A.]

Press Release

University of Pittsburgh School of Medicine Launches Neurological Imaging and Therapeutics Center

The University of Pittsburgh School of Medicine announced the launch of the Alba Tull Center for Neuro Imaging and Therapeutics.The center will be dedicated to designing and expanding imaging technologies for patient care to produce a new, sophisticated understanding of the brain at the molecular level with the goal of developing anti-aging therapeutics.
[University of Pittsburgh]

Press Release

Lipidomics of Health and Disease

March 24 – 26, 2021

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Postdoctoral Position – Hematopoietic Development

Icahn School of Medicine at Mount Sinai – New York, New York, United States

Postdoctoral Fellow – p53 and Metabolism

The Francis Crick Institute – London, England, United Kingdom

Postdoctoral Positions – Hematopoiesis, Leukemia, Cancer, Human Pluripotent Stem Cells

Icahn School of Medicine at Mount Sinai – New York, New York, United States

Postdoctoral Researcher – Mesenchymal Niche in Leukemia

Karolinska Institutet – Flemingsberg, Sweden

Postdoctoral Fellowship – Human Cancers

Memorial Sloan Kettering Cancer Center – New York, New York, United States

> See All Jobs

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