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Vol. 10.06 – 17 February, 2021
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Using two orthogonal-acting inhibitors of Protein arginine methyltransferase 5 (PRMT5), researchers showed that pharmacological inhibition of PRMT5 suppressed the growth of a cohort of 46 patient-derived glioblastoma stem cell cultures, with the proneural subtype showing greater sensitivity. [Nature Communications]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors identified NOTCH1 as a central switch between the perivascular niche and network niche in glioma, and demonstrated robust cross-compensation when only one niche was targeted.
[Nature Communications]
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Scientists showed that the receptor tyrosine kinase Met promoted YAP activity in basal-like breast cancer and found enhanced YAP activity within the CSC population. [Cancer Research]
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Induction and function of BRD/H3k27Ac-dependent immunosuppressive genes played a role in the immunosuppressive phenotype of stem-like tumor-propagating cells in GBM.
[Cancer Research]
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Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]
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Immunofluorescence was used for antigen localization. After targeted antigen purification by electrophoresis and immunoblot, the antigen was identified by LC-MALDI-TOF/TOF mass spectrometry, immunofluorescence, and immunoprecipitation.
[Stem Cell Research & Therapy]
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Scientists checked the combined effect of CD133 siRNA and Oxaliplatin on proliferation, migration, apoptosis, and stemness properties of olorectal cancer cells in the HT-29 cell line.
[Biomedicine & Pharmacotherapy]
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Investigators recapitulated the tumor cells-macrophages interactions in cell culture using prostate cancer cell lines.
[Biophysical Journal]
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The authors investigated the function of the CSC marker aldehyde dehydrogenase in retinoic acid cell signaling using an in vitro model of cisplatin resistant non-small cell lung cancer. [Translational Oncology]
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Investigators review the identification of CSCs, the intrinsic and extrinsic mechanisms of therapy resistance in CSCs, the signaling pathways of CSCs that mediate treatment failure, and potential CSC-targeting agents in various tumors from the clinical perspective.
[Signal Transduction and Targeted Therapy]
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Many CSC phenotypes including metabolism, epithelial-to-mesenchymal transition, cellular signaling pathway activity, and others, arise from altered mitochondrial function and turnover, which are regulated by constant cycles of mitochondrial fusion and fission.
[Cellular and Molecular Life Sciences]
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Investigators recapitulate the multifaceted action exerted by focal adhesion kinase and its prognostic significance in breast cancer. [Cancers]
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Oryzon Genomics, S.A. announced that the FDA has granted Orphan Drug Designation to the company’s first-in-class LSD1 inhibitor iadademstat for the treatment of patients with acute myeloid leukemia.
[Oryzon Genomics, S.A.]
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The University of Pittsburgh School of Medicine announced the launch of the Alba Tull Center for Neuro Imaging and Therapeutics.The center will be dedicated to designing and expanding imaging technologies for patient care to produce a new, sophisticated understanding of the brain at the molecular level with the goal of developing anti-aging therapeutics. [University of Pittsburgh]
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March 24 – 26, 2021 Virtual
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Icahn School of Medicine at Mount Sinai – New York, New York, United States
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The Francis Crick Institute – London, England, United Kingdom
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Icahn School of Medicine at Mount Sinai – New York, New York, United States
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Karolinska Institutet – Flemingsberg, Sweden
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Memorial Sloan Kettering Cancer Center – New York, New York, United States
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