Cancer Stem Cell News Volume 10.07 | Feb 24 2021

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    2021-02-24 | CSCN 10.07


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.07 – 24 February, 2021
    TOP STORY

    The miR-181a-SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer

    Using a miRNA sensor-based approach, scientists identified miR-181a as a novel driver of Wnt/β-catenin signaling. miR-181ahigh primary HGSOC cells exhibited increased Wnt/β-catenin signaling, which was associated with increased stem-cell frequency and platinum resistance.
    [Cancer Research]

    Abstract
    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

    Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
    [Cancer Research]

    Abstract

    Distinct Functions of Transforming Growth Factor-β Signaling in C-MYC Driven Hepatocellular Carcinoma Initiation and Progression

    The authors investigated the expression of TGFβ signaling in c-MYC amplified human hepatocellular carcinoma samples as well as the mechanisms whereby TGFβ modulated c-Myc driven hepatocarcinogenesis during initiation and progression.
    [Cell Death & Disease]

    Full Article

    Expression of Immune Checkpoints on Circulating Tumor Cells in Men with Metastatic Prostate Cancer

    Researchers characterized circulating tumor cells for expression of immune checkpoint ligands in men with metastatic prostate cancer as a non-invasive biomarker of immune evasion and immunotherapy benefit.
    [Biomarker Research]

    Full Article

    YBX2 and Cancer Testis Antigen 45 Contribute to Stemness, Chemoresistance and a High Degree of Malignancy in Human Endometrial Cancer

    Investigators clarified the function of Y-box binding protein 2 (YBX2) in endometrial CSCs. They established a human YBX2-expressing Ishikawa cell line.
    [Scientific Reports]

    Full Article

    Exploitation of the Vitamin A/Retinoic Acid Axis Depletes ALDH1-Positive Cancer Stem Cells and Re-Sensitizes Resistant Non-Small Cell Lung Cancer Cells to Cisplatin

    The authors investigated the function of the CSC marker aldehyde dehydrogenase in retinoic acid cell signaling using an in vitro model of cisplatin resistant non-small cell lung cancer.
    [Translational Oncology]

    Full Article

    Heterogeneous Glioma Cell Invasion under Interstitial Flow Depending on Their Differentiation Status

    Researchers investigated how glioma initiating cells invaded 3D hydrogels in response to an interstitial flow with respect to their differentiation status. Microfluidic culture systems were used to apply an interstitial flow to the cells migrating from the cell aggregates into the 3D hydrogel.
    [Tissue Engineering Part A]

    Abstract

    Tumor Co-Expression of Progranulin and Sortilin as a Prognostic Biomarker in Breast Cancer

    The authors explored how co-expression of progranulin and sortilin was associated with established clinical markers by analyzing a tissue microarray including 560 randomized premenopausal breast cancer patients receiving either two years of tamoxifen treatment or no adjuvant treatment, with a median follow-up time of 28 years.
    [BMC Cancer]

    Full Article

    A Unique Subset of Glycolytic Tumor-Propagating Cells Drives Squamous Cell Carcinoma

    Investigators showed that the NAD+-dependent histone deacetylase sirtuin 6 was a robust tumor suppressor in head and neck squamous cell carcinoma, acting as a modulator of glycolysis in these tumors.
    [Nature Metabolism]

    Abstract
    Survey Report: Where Is Pluripotent Stem Cell Research Now?
    REVIEWS

    Context-Dependent Roles of YAP/TAZ in Stem Cell Fates and Cancer

    The authors present an overview of the multiple context-dependent functions of YAP and TAZ in regulating cell fate decisions in stem cells and organoids, as well as their mechanisms of controlling programmed cell death pathways in cancer.
    [Cellular and Molecular Life Sciences]

    Full Article

    Epigenetic Targeting of Cancer Stem Cells by Polyphenols (Cancer Stem Cells Targeting)

    The noticeable and specific pathways in CSCs can be organized by epigenetic mechanisms such as DNA methylation, chromatin remodeling, regulatory RNAs, among others. Since epigenetics modifications can be changed and reversed, it is a possible tool for cancer control and treatment.
    [Phytotherapy Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Therapeutic Solutions International Uses StemVacs™ Platform to Generate Personalized Adoptive T Cell Therapy Targeting Cancer Stem Cells

    Therapeutic Solutions International, Inc., reported novel data and filing of a patent application demonstrating that StemVacs™ cells carrying proprietary sequences from the cancer-specific antigen Brother of the Regulator of Imprinted Sites, were able to elicit the generation of T cells capable of selectively killing cancer stem cells.
    [Therapeutic Solutions International, Inc. (PR Newswire)]

    Press Release

    A Molecular Biologist Has Been Awarded Funding to Support a New Method of Research into Blood Cancer

    Dr. Salvatore Papa, an Assistant Professor in Cancer Research at the University of Leeds, has been awarded Leukaemia & Myeloma Research UK’s research grant to continue his specialist studies into examining how the accumulation of mutated proteins in certain blood cancer cells allows them to multiply repeatedly.
    [Charity Today]

    Press Release
    FEATURED EVENT

    Lipidomics of Health and Disease

    March 24 – 26, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Cancer Immunotherapy

    University of Notre Dame – Notre Dame, Indiana, United States

    Postdoctoral Fellow – Signaling Pathways and Melanoma

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – p53 and Metabolism

    The Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Positions – Hematopoiesis, Leukemia, Cancer, Human Pluripotent Stem Cells

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Researcher – Mesenchymal Niche in Leukemia

    Karolinska Institutet – Flemingsberg, Sweden

    > See All Jobs

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