| Vol. 10.07 – 24 February, 2021
| Using a miRNA sensor-based approach, scientists identified miR-181a as a novel driver of Wnt/β-catenin signaling. miR-181ahigh primary HGSOC cells exhibited increased Wnt/β-catenin signaling, which was associated with increased stem-cell frequency and platinum resistance.
| PUBLICATIONSRanked by the impact factor of the journal
| Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
| The authors investigated the expression of TGFβ signaling in c-MYC amplified human hepatocellular carcinoma samples as well as the mechanisms whereby TGFβ modulated c-Myc driven hepatocarcinogenesis during initiation and progression.
[Cell Death & Disease]
| Researchers characterized circulating tumor cells for expression of immune checkpoint ligands in men with metastatic prostate cancer as a non-invasive biomarker of immune evasion and immunotherapy benefit.
| Investigators clarified the function of Y-box binding protein 2 (YBX2) in endometrial CSCs. They established a human YBX2-expressing Ishikawa cell line.
| The authors investigated the function of the CSC marker aldehyde dehydrogenase in retinoic acid cell signaling using an in vitro model of cisplatin resistant non-small cell lung cancer.
| Researchers investigated how glioma initiating cells invaded 3D hydrogels in response to an interstitial flow with respect to their differentiation status. Microfluidic culture systems were used to apply an interstitial flow to the cells migrating from the cell aggregates into the 3D hydrogel.
[Tissue Engineering Part A]
| The authors explored how co-expression of progranulin and sortilin was associated with established clinical markers by analyzing a tissue microarray including 560 randomized premenopausal breast cancer patients receiving either two years of tamoxifen treatment or no adjuvant treatment, with a median follow-up time of 28 years.
| Investigators showed that the NAD+-dependent histone deacetylase sirtuin 6 was a robust tumor suppressor in head and neck squamous cell carcinoma, acting as a modulator of glycolysis in these tumors.
| The authors present an overview of the multiple context-dependent functions of YAP and TAZ in regulating cell fate decisions in stem cells and organoids, as well as their mechanisms of controlling programmed cell death pathways in cancer.
[Cellular and Molecular Life Sciences]
| The noticeable and specific pathways in CSCs can be organized by epigenetic mechanisms such as DNA methylation, chromatin remodeling, regulatory RNAs, among others. Since epigenetics modifications can be changed and reversed, it is a possible tool for cancer control and treatment.
| Therapeutic Solutions International, Inc., reported novel data and filing of a patent application demonstrating that StemVacs™ cells carrying proprietary sequences from the cancer-specific antigen Brother of the Regulator of Imprinted Sites, were able to elicit the generation of T cells capable of selectively killing cancer stem cells.
[Therapeutic Solutions International, Inc. (PR Newswire)]
| Dr. Salvatore Papa, an Assistant Professor in Cancer Research at the University of Leeds, has been awarded Leukaemia & Myeloma Research UK’s research grant to continue his specialist studies into examining how the accumulation of mutated proteins in certain blood cancer cells allows them to multiply repeatedly.
| March 24 – 26, 2021
| University of Notre Dame – Notre Dame, Indiana, United States
| The Wistar Institute – Philadelphia, Pennsylvania, United States
| The Francis Crick Institute – London, England, United Kingdom
| Icahn School of Medicine at Mount Sinai – New York, New York, United States
| Karolinska Institutet – Flemingsberg, Sweden