Cancer Stem Cell News Volume 10.11 | Mar 24 2021


    24-03-2021 | CSCN 10.11

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.11 – 24 March, 2021

    FTO-Mediated Cytoplasmic m6Am Demethylation Adjusts Stem-Like Properties in Colorectal Cancer Cell

    Researchers showed that the cytoplasmic pool of fat mass and obesity-associated protein (FTO) impeded cancer stem cellabilities in colorectal cancer through its N6,2’-O-dimethyladenosine (m6Am) demethylase activity.
    [Nature Communications]

    Full Article
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Transmembrane and Coiled-Coil Domain Family 3 (TMCC3) Regulates Breast Cancer Stem Cell and AKT Activation

    Researchers demonstrated greater expression of TMCC3 in breast cancer stem cells (BCSCs) than non-BCSCs and higher expression of TMCC3 in metastatic lymph nodes and lungs than in primary tumor of breast cancer patient-derived xenograft.

    Full Article

    Circulating Stromal Cells in Resectable Pancreatic Cancer Correlates to Pathological Stage and Predicts for Poor Clinical Outcomes

    Blood samples were procured from 63 pancreatic cancer patients prior to the start of therapeutic intent. Cancer associated macrophage-like cells (CAMLs) were found in 95% of samples tested, with ≥12 CAMLs/7.5 mL and ≥50 µm CAMLs both predicting for advanced pathological stage and progression free survival.
    [npj Precision Oncology]

    Full Article

    CircFAM73A Promotes the Cancer Stem Cell-Like Properties of Gastric Cancer through the miR-490-3p/HMGA2 Positive Feedback Loop and HNRNPK-Mediated β-Catenin Stabilization

    The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    HIF1α/HIF2α–Sox2/Klf4 Promotes the Malignant Progression of Glioblastoma via the EGFR–PI3K/AKT Signaling Pathway with Positive Feedback under Hypoxia

    Scientists discovered that glioblastoma cells exhibited features indicative of malignant progression and were present in a hypoxic environment.
    [Cell Death & Disease]

    Full Article

    Detection of Clustered Circulating Tumor Cells in Early Breast Cancer

    Exploiting nanostructured titanium oxide-coated slides for shear-free circulating tumor cell (CTC) identification, the authors detected clustered CTCs in the curative setting of multiple patients with early breast cancer prior to surgical treatment, highlighting their presence already at early disease stages.
    [British Journal of Cancer]

    Full Article

    SOCS6 Promotes Radiosensitivity and Decreases Cancer Cell Stemness in Esophageal Squamous Cell Carcinoma by Regulating C-Kit Ubiquitylation

    57 esophageal squamous cell carcinoma (ESCC) patients were enrolled for survival analysis. SOCS6 was stably overexpressed in HPV+ ESCC and ESCC cells, and cells were treated with radiation and then subjected to colony formation assays.
    [Cancer Cell International]

    Full Article

    Development and Validation for Prognostic Nomogram of Epithelial Ovarian Cancer Recurrence Based on Circulating Tumor Cells and Epithelial–Mesenchymal Transition

    Investigators used CanPatrol circulating tumor cells (CTC)-enrichment technique to detect CTCs from blood samples and classify subpopulations into epithelial, mesenchymal, and hybrids.
    [Scientific Reports]

    Full Article

    Neuregulin-1-β1 and γ-Secretase Play a Critical Role in Sphere-Formation and Cell Survival of Urothelial Carcinoma Cancer Stem-Like Cells

    NRG1 has been determined to be involved in frequent gene fusions with other partners in several malignancies and has a role in carcinogenesis through the NRG1 EGF-like domain and its cognitive receptor ERBBs. Researchers elucidated the function of NRG1 in urothelial carcinoma CSCs/cancer-initiating cells.
    [Biochemical and Biophysical Research Communications]


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    Novel Molecular Regulators of Breast Cancer Stem Cell Plasticity and Heterogeneity

    Investigators summarize the novel regulators in breast cancer stem cells (BCSCs) and their niches for BCSC heterogeneity which has been discovered in recent years, and discuss their regulation mechanisms and the latest corresponding cancer treatments.
    [Seminars in Cancer Biology]

    Full Article

    Cancer Stem Cells in Colorectal Cancer and the Association with Chemotherapy Resistance

    The characteristic surface markers of CSCs and the related mechanism of drug resistance are discussed in detail by the authors.
    [Medical Oncology]


    BERG to Conduct Phase II Trial for Treatment Of Deadly Glioblastoma Multiforme (GBM)

    BERG Health announced with leading cancer centers that the FDA has authorized a Phase II trial in GBM patients in neo-adjuvant settings using BERG’s BPM 31510.
    [BERG Health (PR Newswire, LLC.)]

    Press Release

    New ASH Research Restart Award to Help Ensure Research Continuity and Workforce Stability during Pandemic

    The American Society of Hematology announced the names of 19 talented early-career investigators who will receive critical funding to support their resumption of research that was paused amid pandemic-related shutdowns and uncertainty.
    [Amercian Society of Hematology]

    Press Release

    Curating the Clinical Genome

    May 12 – 14, 2021

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    Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

    Almac – Belfast, Ireland

    Director – Ginny L. Clements Breast Cancer Research Institute

    University of Arizona Cancer Center – Tucson, Arizona, United States

    Research Coordinator – Breast Oncology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Scholar Position – Hormone Therapy Resistance in Prostate Cancer

    Duke University – Durham, North Carolina, United States

    Assistant Professor – Neuro-Oncology

    University of California, San Francisco – San Francisco, California, United States

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