 | | Vol. 10.11 – 24 March, 2021 |
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| Researchers showed that the cytoplasmic pool of fat mass and obesity-associated protein (FTO) impeded cancer stem cellabilities in colorectal cancer through its N6,2’-O-dimethyladenosine (m6Am) demethylase activity.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated greater expression of TMCC3 in breast cancer stem cells (BCSCs) than non-BCSCs and higher expression of TMCC3 in metastatic lymph nodes and lungs than in primary tumor of breast cancer patient-derived xenograft.
[Oncogene] |
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| Blood samples were procured from 63 pancreatic cancer patients prior to the start of therapeutic intent. Cancer associated macrophage-like cells (CAMLs) were found in 95% of samples tested, with ≥12 CAMLs/7.5 mL and ≥50 µm CAMLs both predicting for advanced pathological stage and progression free survival.
[npj Precision Oncology] |
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| The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists discovered that glioblastoma cells exhibited features indicative of malignant progression and were present in a hypoxic environment.
[Cell Death & Disease] |
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| Exploiting nanostructured titanium oxide-coated slides for shear-free circulating tumor cell (CTC) identification, the authors detected clustered CTCs in the curative setting of multiple patients with early breast cancer prior to surgical treatment, highlighting their presence already at early disease stages.
[British Journal of Cancer] |
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| 57 esophageal squamous cell carcinoma (ESCC) patients were enrolled for survival analysis. SOCS6 was stably overexpressed in HPV+ ESCC and ESCC cells, and cells were treated with radiation and then subjected to colony formation assays.
[Cancer Cell International] |
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| Investigators used CanPatrol circulating tumor cells (CTC)-enrichment technique to detect CTCs from blood samples and classify subpopulations into epithelial, mesenchymal, and hybrids.
[Scientific Reports] |
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| NRG1 has been determined to be involved in frequent gene fusions with other partners in several malignancies and has a role in carcinogenesis through the NRG1 EGF-like domain and its cognitive receptor ERBBs. Researchers elucidated the function of NRG1 in urothelial carcinoma CSCs/cancer-initiating cells.
[Biochemical and Biophysical Research Communications] |
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| Investigators summarize the novel regulators in breast cancer stem cells (BCSCs) and their niches for BCSC heterogeneity which has been discovered in recent years, and discuss their regulation mechanisms and the latest corresponding cancer treatments.
[Seminars in Cancer Biology] |
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| The characteristic surface markers of CSCs and the related mechanism of drug resistance are discussed in detail by the authors.
[Medical Oncology] |
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| BERG Health announced with leading cancer centers that the FDA has authorized a Phase II trial in GBM patients in neo-adjuvant settings using BERG’s BPM 31510.
[BERG Health (PR Newswire, LLC.)] |
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| The American Society of Hematology announced the names of 19 talented early-career investigators who will receive critical funding to support their resumption of research that was paused amid pandemic-related shutdowns and uncertainty.
[Amercian Society of Hematology] |
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| | University of Arizona Cancer Center – Tucson, Arizona, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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